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Treatment patterns in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma post covalent Bruton tyrosine kinase inhibitor treatment: a Japanese claims database study
In conclusion, Japanese patients with CLL/SLL received various treatments for short duration after first-cBTKi discontinuation.PMID:38148012 | DOI:10.3960/jslrt.23032 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Dai Maruyama Chaochen Wang Yoshinori Tanizawa Zhihong Cai Yujing Huang Masaomi Tajimi Shigeru Kusumoto Source Type: research

Evidence for distinct mechanisms of immune suppression in EBV-positive and EBV-negative Hodgkin lymphoma
In this study, we aimed to investigate the prevalence of EBV among HL cases in Ethiopia and to assess the tissue cellular composition of EBV-related and EBV-unrelated cases. We constructed a tissue microarray (TMA) of 126 consecutive cases of classical HL (CHL) and nodular lymphocyte predominant HL (NLPHL) from a tertiary cancer centre, Tikur Anbessa Hospital, Addis Ababa, Ethiopia, and evaluated a panel of immunohistochemical markers. The quantification of immune cells was performed using HALO 2.3, a platform for image analysis from Indica Lab Inc. A total of 77/126 (61.1%) of HL cases expressed LMP1/EBER. Infiltration of...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Makka Adam Yonas Bekuretsion Amha Gebremedhin Anna Kwiecinska Rawleigh Howe Beyene Petros Mats Jerkeman Source Type: research

Sutimlimab suppresses SARS-CoV-2 mRNA vaccine-induced hemolytic crisis in a patient with cold agglutinin disease
This report suggests that appropriate sutimlimab administration can suppress SARS-CoV-2 mRNA vaccination-induced CAD exacerbation, and that it could be a preventive strategy to minimize hemolytic attacks in susceptible populations.PMID:38148014 | DOI:10.3960/jslrt.23040 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Hiroki Kobayashi Tomoki Ouchi Wataru Kitamura Shoji Asakura Tomofumi Yano Hiromasa Takeda Yoshiyuki Tokuda Tadashi Yoshino Yoshinobu Maeda Source Type: research

Methotrexate-induced subacute myelopathy: a serious but treatable complication
J Clin Exp Hematop. 2023;63(4):251-256. doi: 10.3960/jslrt.23041.ABSTRACTSubacute myelopathy is a rare but serious complication of methotrexate (MTX) that may cause paraplegia. Although its underlying mechanisms have not been fully elucidated, homocysteine is thought to play a role in the pathogenesis of this adverse effect. Herein, we report the case of a 34-years old female patient with diffuse large B-cell lymphoma who developed progressive paraplegia accompanied by dysfunctional bladder and bowel movements after treatment with a modified CODOX-M/IVAC regimen, including high-dose intravenous MTX and intrathecal (IT-) MT...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Takashi Miyoshi Tadakazu Kondo Momoko Nishikori Toshio Kitawaki Katsuya Kobayashi Masakazu Fujimoto Noriyoshi Yoshinaga Satoshi Oka Kohsuke Asagoe Shinsaku Imashuku Akifumi Takaori-Kondo Source Type: research

Coincidence of de novo T-lymphoblastic lymphoma and cutaneous gamma/delta peripheral T-cell lymphoma
J Clin Exp Hematop. 2023;63(4):257-261. doi: 10.3960/jslrt.23042.ABSTRACTThe coincidence of acute T-lymphoblastic leukemia/lymphoma, NOS (T-ALL/LBL), and peripheral T-cell lymphoma (PTCL) is unusual, and there have only been a few cases of their metachronous occurrence. In these cases, PTCLs emerged as recurrence after primary therapy for primary T-ALL, were the rare gamma/delta type, and uncommonly involved skin for T-ALL/LBL. We herein report the first case of de novo T-LBL that coincided with cutaneous gamma/delta PTCL before primary therapy. A 70-year-old man presented with systemic lymphadenopathy. Lymph node biopsy r...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Tsugumi Satoh Hidekazu Kayano Mika Kohri Ken Tanae Chie Asou Naoki Takahashi Kunihiro Tsukasaki Masanori Yasuda Source Type: research

Use of R-mini-CHP in combination with polatuzumab vedotin (pola-R-mini-CHP) as the primary treatment in ≥80-year-old cases with diffuse large B-cell lymphoma
J Clin Exp Hematop. 2023;63(4):262-265. doi: 10.3960/jslrt.23043.NO ABSTRACTPMID:38148017 | DOI:10.3960/jslrt.23043 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Yasunobu Sekiguchi Hiroki Tsutsumi Ayumi Gomyo Masahisa Kudo Yoshie Iizaki Nobuo Maseki Machiko Kawamura Kazuhiko Kobayashi Yu Nishimura Hiroaki Kanda Hideaki Nitta Masaaki Noguchi Hirofumi Kobayashi Source Type: research

Highlights: Follicular lymphoma
J Clin Exp Hematop. 2023;63(4):212-213. doi: 10.3960/jslrt.23051.NO ABSTRACTPMID:38148010 | DOI:10.3960/jslrt.23051 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Katsuyoshi Takata Source Type: research

Clinico-pathological profile of patients with plasma cell neoplasms with special reference to bone marrow fibrosis and amyloid deposition
In conclusion, the incidence of fibrosis (4.3%) and amyloidosis (6.2%) associated with plasma cell neoplasms were much lower in our study as compared to published studies.PMID:38148011 | DOI:10.3960/jslrt.23029 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Narasimhapriyan Kannan Jasmita Dass Sahitya Dangudubiyyam Ganesh Kumar Viswanathan Mukul Aggarwal Pradeep Kumar Rishi Dhawan Tulika Seth Manoranjan Mahapatra Source Type: research

Significant response of patients with transformed follicular lymphoma with rapid disease progression to CAR-T therapy
J Clin Exp Hematop. 2023 Dec 26;63(4):266-269. doi: 10.3960/jslrt.23033. Epub 2023 Nov 30.NO ABSTRACTPMID:38030235 | DOI:10.3960/jslrt.23033 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - November 29, 2023 Category: Hematology Authors: Taichi Hirano Hiro Tatetsu Shikiko Ueno Takafumi Shichijo Shota Furukawa Mizuho Tsujihashi Toshikazu Miyakawa Shinya Shiraishi Yusuke Higuchi Mitsuhiro Uchiba Jun-Ichirou Yasunaga Kisato Nosaka Masao Matsuoka Source Type: research