Journal of Clinical and Experimental Hematopathology : JCEH This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research

Highlights: Follicular lymphoma
J Clin Exp Hematop. 2023;63(4):212-213. doi: 10.3960/jslrt.23051.NO ABSTRACTPMID:38148010 | PMC:PMC10861372 | DOI:10.3960/jslrt.23051 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Katsuyoshi Takata Source Type: research

Clinico-pathological profile of patients with plasma cell neoplasms with special reference to bone marrow fibrosis and amyloid deposition
In conclusion, the incidence of fibrosis (4.3%) and amyloidosis (6.2%) associated with plasma cell neoplasms were much lower in our study as compared to published studies.PMID:38148011 | PMC:PMC10861367 | DOI:10.3960/jslrt.23029 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Narasimhapriyan Kannan Jasmita Dass Sahitya Dangudubiyyam Ganesh Kumar Viswanathan Mukul Aggarwal Pradeep Kumar Rishi Dhawan Tulika Seth Manoranjan Mahapatra Source Type: research

Treatment patterns in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma post covalent Bruton tyrosine kinase inhibitor treatment: a Japanese claims database study
In conclusion, Japanese patients with CLL/SLL received various treatments for short duration after first-cBTKi discontinuation.PMID:38148012 | PMC:PMC10861376 | DOI:10.3960/jslrt.23032 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Dai Maruyama Chaochen Wang Yoshinori Tanizawa Zhihong Cai Yujing Huang Masaomi Tajimi Shigeru Kusumoto Source Type: research

Evidence for distinct mechanisms of immune suppression in EBV-positive and EBV-negative Hodgkin lymphoma
In this study, we aimed to investigate the prevalence of EBV among HL cases in Ethiopia and to assess the tissue cellular composition of EBV-related and EBV-unrelated cases. We constructed a tissue microarray (TMA) of 126 consecutive cases of classical HL (CHL) and nodular lymphocyte predominant HL (NLPHL) from a tertiary cancer centre, Tikur Anbessa Hospital, Addis Ababa, Ethiopia, and evaluated a panel of immunohistochemical markers. The quantification of immune cells was performed using HALO 2.3, a platform for image analysis from Indica Lab Inc. A total of 77/126 (61.1%) of HL cases expressed LMP1/EBER. Infiltration of...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Makka Adam Yonas Bekuretsion Amha Gebremedhin Anna Kwiecinska Rawleigh Howe Beyene Petros Mats Jerkeman Source Type: research

Sutimlimab suppresses SARS-CoV-2 mRNA vaccine-induced hemolytic crisis in a patient with cold agglutinin disease
This report suggests that appropriate sutimlimab administration can suppress SARS-CoV-2 mRNA vaccination-induced CAD exacerbation, and that it could be a preventive strategy to minimize hemolytic attacks in susceptible populations.PMID:38148014 | PMC:PMC10861374 | DOI:10.3960/jslrt.23040 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Hiroki Kobayashi Tomoki Ouchi Wataru Kitamura Shoji Asakura Tomofumi Yano Hiromasa Takeda Yoshiyuki Tokuda Tadashi Yoshino Yoshinobu Maeda Source Type: research

Methotrexate-induced subacute myelopathy: a serious but treatable complication
J Clin Exp Hematop. 2023;63(4):251-256. doi: 10.3960/jslrt.23041.ABSTRACTSubacute myelopathy is a rare but serious complication of methotrexate (MTX) that may cause paraplegia. Although its underlying mechanisms have not been fully elucidated, homocysteine is thought to play a role in the pathogenesis of this adverse effect. Herein, we report the case of a 34-years old female patient with diffuse large B-cell lymphoma who developed progressive paraplegia accompanied by dysfunctional bladder and bowel movements after treatment with a modified CODOX-M/IVAC regimen, including high-dose intravenous MTX and intrathecal (IT-) MT...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Takashi Miyoshi Tadakazu Kondo Momoko Nishikori Toshio Kitawaki Katsuya Kobayashi Masakazu Fujimoto Noriyoshi Yoshinaga Satoshi Oka Kohsuke Asagoe Shinsaku Imashuku Akifumi Takaori-Kondo Source Type: research

Coincidence of de novo T-lymphoblastic lymphoma and cutaneous gamma/delta peripheral T-cell lymphoma
J Clin Exp Hematop. 2023;63(4):257-261. doi: 10.3960/jslrt.23042.ABSTRACTThe coincidence of acute T-lymphoblastic leukemia/lymphoma, NOS (T-ALL/LBL), and peripheral T-cell lymphoma (PTCL) is unusual, and there have only been a few cases of their metachronous occurrence. In these cases, PTCLs emerged as recurrence after primary therapy for primary T-ALL, were the rare gamma/delta type, and uncommonly involved skin for T-ALL/LBL. We herein report the first case of de novo T-LBL that coincided with cutaneous gamma/delta PTCL before primary therapy. A 70-year-old man presented with systemic lymphadenopathy. Lymph node biopsy r...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Tsugumi Satoh Hidekazu Kayano Mika Kohri Ken Tanae Chie Asou Naoki Takahashi Kunihiro Tsukasaki Masanori Yasuda Source Type: research

Use of R-mini-CHP in combination with polatuzumab vedotin (pola-R-mini-CHP) as the primary treatment in ≥80-year-old cases with diffuse large B-cell lymphoma
J Clin Exp Hematop. 2023;63(4):262-265. doi: 10.3960/jslrt.23043.NO ABSTRACTPMID:38148017 | PMC:PMC10861370 | DOI:10.3960/jslrt.23043 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Yasunobu Sekiguchi Hiroki Tsutsumi Ayumi Gomyo Masahisa Kudo Yoshie Iizaki Nobuo Maseki Machiko Kawamura Kazuhiko Kobayashi Yu Nishimura Hiroaki Kanda Hideaki Nitta Masaaki Noguchi Hirofumi Kobayashi Source Type: research

Highlights: Follicular lymphoma
J Clin Exp Hematop. 2023;63(4):212-213. doi: 10.3960/jslrt.23051.NO ABSTRACTPMID:38148010 | DOI:10.3960/jslrt.23051 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Katsuyoshi Takata Source Type: research

Clinico-pathological profile of patients with plasma cell neoplasms with special reference to bone marrow fibrosis and amyloid deposition
In conclusion, the incidence of fibrosis (4.3%) and amyloidosis (6.2%) associated with plasma cell neoplasms were much lower in our study as compared to published studies.PMID:38148011 | DOI:10.3960/jslrt.23029 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Narasimhapriyan Kannan Jasmita Dass Sahitya Dangudubiyyam Ganesh Kumar Viswanathan Mukul Aggarwal Pradeep Kumar Rishi Dhawan Tulika Seth Manoranjan Mahapatra Source Type: research

Treatment patterns in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma post covalent Bruton tyrosine kinase inhibitor treatment: a Japanese claims database study
In conclusion, Japanese patients with CLL/SLL received various treatments for short duration after first-cBTKi discontinuation.PMID:38148012 | DOI:10.3960/jslrt.23032 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Dai Maruyama Chaochen Wang Yoshinori Tanizawa Zhihong Cai Yujing Huang Masaomi Tajimi Shigeru Kusumoto Source Type: research

Sutimlimab suppresses SARS-CoV-2 mRNA vaccine-induced hemolytic crisis in a patient with cold agglutinin disease
This report suggests that appropriate sutimlimab administration can suppress SARS-CoV-2 mRNA vaccination-induced CAD exacerbation, and that it could be a preventive strategy to minimize hemolytic attacks in susceptible populations.PMID:38148014 | DOI:10.3960/jslrt.23040 (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 26, 2023 Category: Hematology Authors: Hiroki Kobayashi Tomoki Ouchi Wataru Kitamura Shoji Asakura Tomofumi Yano Hiromasa Takeda Yoshiyuki Tokuda Tadashi Yoshino Yoshinobu Maeda Source Type: research