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Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan
We report a case of isolated CNS recurrence of bilateral PTL. Our patient achieved complete response (CR) after rituximab-combination chemotherapy for PTL. Approximately five years later, isolated CNS recurrence of PTL occurred. Our patient achieved CR again after high-dose methotrexate therapy and autologous stem cell transplantation (ASCT) with a conditioning regimen of thiotepa and busulfan as a consolidation therapy. The secondary failure of platelet recovery, probably caused by busulfan, occurred after the platelet engraftment. Our patient has remained in CR for over three years. The treatment strategy for CNS recurre...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Yasuhiro Tanaka Tomomi Sakai Hiroko Tsunemine Tomoo Ito Nobuyoshi Arima Source Type: research

A case of peripheral T-cell lymphoma in which therapy-related myelodysplastic syndrome developed and a second autologous transplantation was performed
We report a case of therapy-related myelodysplastic syndrome (MDS), which developed 9 years after autologous peripheral blood stem cell transplantation (PBSCT) for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). A 65-year-old male was diagnosed with PTCL-NOS. After 6 cycles of the CHOP (cyclophosphamide [CPA], doxorubicin, vincristine, and prednisone) regimen, he achieved a first complete response (CR). He relapsed 33 months later and received salvage chemotherapy, which consisted of the CHASE regimen (CPA, high-dose cytarabine, dexamethasone, and etoposide). During the recovery phase of the first cycle of ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Shun-Ichiro Nakagawa Yuki Nukii Kanako Mochizuki Akio Uchiyama Yoshinobu Maeda Toshiro Kurokawa Source Type: research

Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan
We report a case of isolated CNS recurrence of bilateral PTL. Our patient achieved complete response (CR) after rituximab-combination chemotherapy for PTL. Approximately five years later, isolated CNS recurrence of PTL occurred. Our patient achieved CR again after high-dose methotrexate therapy and autologous stem cell transplantation (ASCT) with a conditioning regimen of thiotepa and busulfan as a consolidation therapy. The secondary failure of platelet recovery, probably caused by busulfan, occurred after the platelet engraftment. Our patient has remained in CR for over three years. The treatment strategy for CNS recurre...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Yasuhiro Tanaka Tomomi Sakai Hiroko Tsunemine Tomoo Ito Nobuyoshi Arima Source Type: research

A case of peripheral T-cell lymphoma in which therapy-related myelodysplastic syndrome developed and a second autologous transplantation was performed
We report a case of therapy-related myelodysplastic syndrome (MDS), which developed 9 years after autologous peripheral blood stem cell transplantation (PBSCT) for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). A 65-year-old male was diagnosed with PTCL-NOS. After 6 cycles of the CHOP (cyclophosphamide [CPA], doxorubicin, vincristine, and prednisone) regimen, he achieved a first complete response (CR). He relapsed 33 months later and received salvage chemotherapy, which consisted of the CHASE regimen (CPA, high-dose cytarabine, dexamethasone, and etoposide). During the recovery phase of the first cycle of ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Shun-Ichiro Nakagawa Yuki Nukii Kanako Mochizuki Akio Uchiyama Yoshinobu Maeda Toshiro Kurokawa Source Type: research

Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan
We report a case of isolated CNS recurrence of bilateral PTL. Our patient achieved complete response (CR) after rituximab-combination chemotherapy for PTL. Approximately five years later, isolated CNS recurrence of PTL occurred. Our patient achieved CR again after high-dose methotrexate therapy and autologous stem cell transplantation (ASCT) with a conditioning regimen of thiotepa and busulfan as a consolidation therapy. The secondary failure of platelet recovery, probably caused by busulfan, occurred after the platelet engraftment. Our patient has remained in CR for over three years. The treatment strategy for CNS recurre...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Yasuhiro Tanaka Tomomi Sakai Hiroko Tsunemine Tomoo Ito Nobuyoshi Arima Source Type: research

A case of peripheral T-cell lymphoma in which therapy-related myelodysplastic syndrome developed and a second autologous transplantation was performed
We report a case of therapy-related myelodysplastic syndrome (MDS), which developed 9 years after autologous peripheral blood stem cell transplantation (PBSCT) for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). A 65-year-old male was diagnosed with PTCL-NOS. After 6 cycles of the CHOP (cyclophosphamide [CPA], doxorubicin, vincristine, and prednisone) regimen, he achieved a first complete response (CR). He relapsed 33 months later and received salvage chemotherapy, which consisted of the CHASE regimen (CPA, high-dose cytarabine, dexamethasone, and etoposide). During the recovery phase of the first cycle of ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Shun-Ichiro Nakagawa Yuki Nukii Kanako Mochizuki Akio Uchiyama Yoshinobu Maeda Toshiro Kurokawa Source Type: research

Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan
We report a case of isolated CNS recurrence of bilateral PTL. Our patient achieved complete response (CR) after rituximab-combination chemotherapy for PTL. Approximately five years later, isolated CNS recurrence of PTL occurred. Our patient achieved CR again after high-dose methotrexate therapy and autologous stem cell transplantation (ASCT) with a conditioning regimen of thiotepa and busulfan as a consolidation therapy. The secondary failure of platelet recovery, probably caused by busulfan, occurred after the platelet engraftment. Our patient has remained in CR for over three years. The treatment strategy for CNS recurre...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Yasuhiro Tanaka Tomomi Sakai Hiroko Tsunemine Tomoo Ito Nobuyoshi Arima Source Type: research

A case of peripheral T-cell lymphoma in which therapy-related myelodysplastic syndrome developed and a second autologous transplantation was performed
We report a case of therapy-related myelodysplastic syndrome (MDS), which developed 9 years after autologous peripheral blood stem cell transplantation (PBSCT) for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). A 65-year-old male was diagnosed with PTCL-NOS. After 6 cycles of the CHOP (cyclophosphamide [CPA], doxorubicin, vincristine, and prednisone) regimen, he achieved a first complete response (CR). He relapsed 33 months later and received salvage chemotherapy, which consisted of the CHASE regimen (CPA, high-dose cytarabine, dexamethasone, and etoposide). During the recovery phase of the first cycle of ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Shun-Ichiro Nakagawa Yuki Nukii Kanako Mochizuki Akio Uchiyama Yoshinobu Maeda Toshiro Kurokawa Source Type: research

Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan
We report a case of isolated CNS recurrence of bilateral PTL. Our patient achieved complete response (CR) after rituximab-combination chemotherapy for PTL. Approximately five years later, isolated CNS recurrence of PTL occurred. Our patient achieved CR again after high-dose methotrexate therapy and autologous stem cell transplantation (ASCT) with a conditioning regimen of thiotepa and busulfan as a consolidation therapy. The secondary failure of platelet recovery, probably caused by busulfan, occurred after the platelet engraftment. Our patient has remained in CR for over three years. The treatment strategy for CNS recurre...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Yasuhiro Tanaka Tomomi Sakai Hiroko Tsunemine Tomoo Ito Nobuyoshi Arima Source Type: research

A case of peripheral T-cell lymphoma in which therapy-related myelodysplastic syndrome developed and a second autologous transplantation was performed
We report a case of therapy-related myelodysplastic syndrome (MDS), which developed 9 years after autologous peripheral blood stem cell transplantation (PBSCT) for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). A 65-year-old male was diagnosed with PTCL-NOS. After 6 cycles of the CHOP (cyclophosphamide [CPA], doxorubicin, vincristine, and prednisone) regimen, he achieved a first complete response (CR). He relapsed 33 months later and received salvage chemotherapy, which consisted of the CHASE regimen (CPA, high-dose cytarabine, dexamethasone, and etoposide). During the recovery phase of the first cycle of ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Shun-Ichiro Nakagawa Yuki Nukii Kanako Mochizuki Akio Uchiyama Yoshinobu Maeda Toshiro Kurokawa Source Type: research

Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan
We report a case of isolated CNS recurrence of bilateral PTL. Our patient achieved complete response (CR) after rituximab-combination chemotherapy for PTL. Approximately five years later, isolated CNS recurrence of PTL occurred. Our patient achieved CR again after high-dose methotrexate therapy and autologous stem cell transplantation (ASCT) with a conditioning regimen of thiotepa and busulfan as a consolidation therapy. The secondary failure of platelet recovery, probably caused by busulfan, occurred after the platelet engraftment. Our patient has remained in CR for over three years. The treatment strategy for CNS recurre...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 28, 2024 Category: Hematology Authors: Yasuhiro Tanaka Tomomi Sakai Hiroko Tsunemine Tomoo Ito Nobuyoshi Arima Source Type: research

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research