Varicella zoster virus reactivation reported with isatuximab use
J Chemother. 2023 Oct 6:1-4. doi: 10.1080/1120009X.2023.2266201. Online ahead of print.ABSTRACTIsatuximab is a CD38-directed antibody indicated for the treatment of relapsed or refractory multiple myeloma. The Division of Pharmacovigilance at the U.S. Food and Drug Administration (FDA) reviewed case reports from postmarketing sources, including the FDA Adverse Event Reporting System (FAERS), PubMed, and Embase, to investigate a potential association between isatuximab and the risk of varicella zoster virus (VZV) reactivation. We identified 20 reports of which 15 met our case definition and causality criteria. All 15 patien...
Source: Journal of Chemotherapy - October 6, 2023 Category: Cancer & Oncology Authors: Michelle Nadeau Nguyen Gra ça M Dores Afrouz Nayernama S Christopher Jones Source Type: research
Astaxanthin induces autophagy and apoptosis in murine melanoma B16F10-Nex2 cells and exhibits antitumor activity < em > in vivo < /em >
In conclusion, AST has cytotoxic effect in melanoma cells and inhibits cell migration and invasion, indicating a promising use in cancer treatment.PMID:37800867 | DOI:10.1080/1120009X.2023.2264585 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - October 6, 2023 Category: Cancer & Oncology Authors: Fernanda Fernandes Miranda da Cunha Angela Pedroso Tonon Fabricio Machado Luis Rodolpho Travassos Nathalia Grazzia Jo ão Fernando Possatto Agnes Kobayashi Calvo de Sant'ana Rayssa de Mello Lopes Tiago Rodrigues Danilo Ciccone Miguel Fernanda Ramos Gadelh Source Type: research
Rapid health technology assessment of the novel endonuclease inhibitor baloxavir for the treatment of influenza
J Chemother. 2023 Sep 28:1-16. doi: 10.1080/1120009X.2023.2263270. Online ahead of print.ABSTRACTThrough a Rapid Health Technology Assessment (RHTA), we evaluated the efficacy, safety and cost-effectiveness of baloxavir in the treatment of influenza, providing the necessary scientific information and evidence-based basis for healthcare professionals and health insurance decision-makers in making rational selections. Through systematic searches of Pubmed, Embase, Web of Science, The Cochrane Register of Clinical Trials database and the official website of Health Technology Assessment (HTA) agencies, we collected systematic ...
Source: Journal of Chemotherapy - September 28, 2023 Category: Cancer & Oncology Authors: Guangliang Huang Yunfei Tian Wenyan Cui Xinhui Zhang Yonghong Zhao Xiuju Liu Source Type: research
Oritavancin < em > in vitro < /em > activity against Gram-positive organisms from European medical centers: a 10-year longitudinal overview from the SENTRY Antimicrobial Surveillance Program (2010-2019)
J Chemother. 2023 Sep 25:1-11. doi: 10.1080/1120009X.2023.2259673. Online ahead of print.ABSTRACTTo assess oritavancin in vitro activity against clinically relevant Gram-positive pathogens in European (EU) hospitals, a total of 51,531 consecutive and unique clinical isolates collected in 2010-2019 were evaluated. All isolates were tested by CLSI broth microdilution methods. The key resistance phenotypes differed considerably between Eastern Europe (E-EU) and Western Europe (W-EU), respectively: methicillin-resistant (MR) Staphylococcus aureus 27.7%/22.9%; multidrug resistant (MDR) S. aureus, 19.7%/15.2%; MR coagulase-negat...
Source: Journal of Chemotherapy - September 25, 2023 Category: Cancer & Oncology Authors: M A Pfaller R E Mendes H S Sader M Castanheira C G Carvalhaes Source Type: research
CircAGFG1 absence decreases PKM2 expression to enhance oxaliplatin sensitivity in colorectal cancer in a miR-7-5p-dependent manner
J Chemother. 2023 Sep 10:1-14. doi: 10.1080/1120009X.2023.2253680. Online ahead of print.ABSTRACTCircular RNA (circRNA) ArfGAP with FG repeats 1 (circAGFG1) contributes to colorectal cancer (CRC) development. However, whether circAGFG1 regulates the resistance of CRC to oxaliplatin (L-OHP) remains unknown. CircAGFG1, microRNA-7-5p (miR-7-5p) and pyruvate kinase M2 (PKM2) RNA expression were quantified by quantitative real-time polymerase chain reaction. Protein expression was detected by western blot assay and immunohistochemistry assay. Glycolysis was analyzed through glucose uptake, lactate production and adenosine triph...
Source: Journal of Chemotherapy - September 11, 2023 Category: Cancer & Oncology Authors: Jun Chen Hongwei Wang Mingsheng Tang Source Type: research
