The tumor microenvironment: shaping cancer progression and treatment response
J Chemother. 2024 Jan 5:1-30. doi: 10.1080/1120009X.2023.2300224. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) plays a crucial role in cancer progression and treatment response. It comprises a complex network of stromal cells, immune cells, extracellular matrix, and blood vessels, all of which interact with cancer cells and influence tumor behaviour. This review article provides an in-depth examination of the TME, focusing on stromal cells, blood vessels, signaling molecules, and ECM, along with commonly available therapeutic compounds that target these components. Moreover, we explore the TME as a novel ...
Source: Journal of Chemotherapy - January 5, 2024 Category: Cancer & Oncology Authors: Sharav A Desai Vipul P Patel Kunal P Bhosle Sandip D Nagare Kirti C Thombare Source Type: research
Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents
J Chemother. 2024 Jan 5:1-31. doi: 10.1080/1120009X.2023.2300217. Online ahead of print.ABSTRACTDose-limiting toxicities (DLTs) are severe adverse effects that define the maximum tolerated dose of a cancer drug. In addition to the specific mechanisms of each drug, common contributing factors include inflammation, apoptosis, ion imbalances, and tissue-specific enzyme deficiencies. Among various DLTs are bleomycin-induced pulmonary fibrosis, doxorubicin-induced cardiomyopathy, cisplatin-induced nephrotoxicity, methotrexate-induced hepatotoxicity, vincristine-induced neurotoxicity, paclitaxel-induced peripheral neuropathy, an...
Source: Journal of Chemotherapy - January 5, 2024 Category: Cancer & Oncology Authors: Mohammad Amin Manavi Mohammad Hosein Fathian Nasab Razieh Mohammad Jafari Ahmad Reza Dehpour Source Type: research
Statement of Retraction: Angiotensin II receptor antagonist olmesartan and NF-kappaB inhibitor as cytotoxic and apoptotic agents in MCF-7 human cell line
J Chemother. 2024 Jan 2:1. doi: 10.1080/1120009X.2023.2296759. Online ahead of print.NO ABSTRACTPMID:38166589 | DOI:10.1080/1120009X.2023.2296759 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - January 3, 2024 Category: Cancer & Oncology Source Type: research
Macrolides impact the growth ability of clinical < em > Pseudomonas aeruginosa < /em > through quorum-sensing systems
In conclusion, our results confirmed that macrolides could be used in combination with last-line antibiotics, such as carbapenems, to treat infections caused by multidrug-resistant Gram-negative bacteria.PMID:38156440 | DOI:10.1080/1120009X.2023.2296150 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - December 29, 2023 Category: Cancer & Oncology Authors: Katerina Apostolaki Lazaros A Gagaletsios Costas C Papagiannitsis Efthimia Petinaki Source Type: research
Fixed-dose antiretroviral combinations in children living with human immunodeficiency virus type 1 (HIV-1): a systematic review
J Chemother. 2023 Dec 28:1-15. doi: 10.1080/1120009X.2023.2297095. Online ahead of print.ABSTRACTFixed-Dose antiretroviral Combinations (FDCs) are the most used drug regimes in adult patients with human-immunodeficiency virus 1 infection, since they increase adherence to antiretroviral therapy and enable good quality of life. The European AIDS Clinical Society guidelines recommend the use of FDCs in paediatrics. However, the use of FDCs in paediatric population is restricted since studies in children and adolescents are mostly conducted in small sample sizes and are heterogeneous in settings and design. This systematic rev...
Source: Journal of Chemotherapy - December 28, 2023 Category: Cancer & Oncology Authors: Federica Attaianese Irene Dalpiaz Martina Failla Elisa Pasquali Luisa Galli Elena Chiappini Source Type: research
Prognostic and immunological values of SKA3 for overall survival in lung adenocarcinoma and its RNA binding protein involved mechanisms
This article aimed to investigate the correlations among SKA3 expression and prognosis, clinical relevance, tumor immunity, and RNA-binding protein (RBP)-involved mechanisms for overall survival (OS) in lung adenocarcinoma (LUAD). To explore the SKA3 expression level in LUAD by analyzing the genomic data as well as related clinical characteristics from the database of TCGA. Nomogram and gene set enrichment analysis (GSEA) were applied, respectively, to evaluate the performance of SKA3 in LUAD. Correlations between SKA3 and immunity and RBP-involved mechanisms were also performed. SKA3 had a higher expression level in LUAD ...
Source: Journal of Chemotherapy - December 26, 2023 Category: Cancer & Oncology Authors: Yinfeng Gu Jinjin Li Hongjun Guan Changpeng Sun Source Type: research
Upregulation of apoptotic genes and downregulation of target genes of Sonic Hedgehog signaling pathway in DAOY medulloblastoma cell line treated with arsenic trioxide
J Chemother. 2023 Dec 22:1-14. doi: 10.1080/1120009X.2023.2294574. Online ahead of print.ABSTRACTSonic hedgehog (SHH) medulloblastoma etiology is associated with the SHH molecular pathway activation at different levels. We investigated the effect of arsenic trioxide as a downstream-level inhibitor of the SHH signaling pathway on morphology, cytotoxicity, migration, and SHH-related and apoptotic gene expression of DAOY cells. Cells were treated at various arsenic trioxide (ATO)concentrations (1, 2, 3, 5, and 10 μM) for different times (24 and 48 hr). Following treatments, the morphology of the cells was investigated at ×2...
Source: Journal of Chemotherapy - December 22, 2023 Category: Cancer & Oncology Authors: Mehrdad Ghorbanlou Fatemeh Moradi Ronak Shabani Mehdi Mehdizadeh Source Type: research
Impact of a hospital sepsis management protocol on the selection of empirical antibiotics in infectious disease consultations
This study highlights the significance of using a structured protocol to attain appropriate empirical treatment for patients suspected of sepsis, even in a setting where IDC is readily available.PMID:38131316 | DOI:10.1080/1120009X.2023.2296146 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - December 22, 2023 Category: Cancer & Oncology Authors: Asl ı Özden B üşra Dalgıç Mervenur Demir G ülşen Hazırolan Ömrüm Uzun G ökhan Metan Source Type: research
