Antibiotic adjuvant activities of quorum sensing signal molecules DSF and BDSF against mature biofilms of Staphylococci
J Chemother. 2023 Oct 24:1-13. doi: 10.1080/1120009X.2023.2270743. Online ahead of print.ABSTRACTAmong promising antibiofilm compounds, quorum-sensing (QS) molecules that regulate biological processes such as biofilm formation and intra- or interspecies communication appear to be good candidates. The invitro antibiotic-adjuvant effects of QS molecules diffusible signal factor (DSF) and B. cenocepacia producing-DSF (BDSF) were investigated against mature Staphylococcal biofilms. Broth microdilution methods were used for the determinations of MIC, MBC, MBIC, and MBEC, and bactericidal activities were determined by TKC method...
Source: Journal of Chemotherapy - October 24, 2023 Category: Cancer & Oncology Authors: Merve Bilgin Sibel Dosler Gulten Otuk Source Type: research
Characteristics and predictors of infusion-related reactions to rituximab in patients with B-cell non-Hodgkin lymphoma
J Chemother. 2023 Oct 20:1-8. doi: 10.1080/1120009X.2023.2270833. Online ahead of print.ABSTRACTThis retrospective study aimed to assess the characteristics and predictors of infusion-related reactions (IRRs) to rituximab in patients with B-cell non-Hodgkin lymphoma (B-NHL). The medical records of adult patients with B-NHL who received their first cycle of rituximab from August 2020 to August 2022 were reviewed. IRRs were defined as any signs experienced by patients during rituximab infusion and graded according to the Common Terminology Criteria for Adverse Events. During the study period, 334 patients were included; amon...
Source: Journal of Chemotherapy - October 20, 2023 Category: Cancer & Oncology Authors: Nour Faqeer Rawaa Alrabie Rand Al-Haddadin Mohammad Ma'koseh Source Type: research
Nivolumab-induced Lambert-Eaton myasthenic syndrome: an immune-related adverse event in nonsmall cell lung cancer
In this report, we describe a rare case of Lambert-Eaton myasthenic syndrome (LEMS), which developed as a side effect of nivolumab in a patient with metastatic lung squamous cell carcinoma. Our patient, who was previously treated with nivolumab for metastatic squamous cell carcinoma of the lung, appeared with a headache, swollen face, dysarthria, asthenia, xerostomia, and drooping eyelid. Early testing indicated no thymomas or newly developing tumors in whole-body scans, and the blood workup was normal. We came to the conclusion that nivolumab-induced LEMS was the cause of the symptoms after performing nerve conduction inv...
Source: Journal of Chemotherapy - October 14, 2023 Category: Cancer & Oncology Authors: Syed Tabish Rehman Syeda Mahnoor Azeem Areeba Akbar Omer Shafiq Syed Shehryar Azeem Shabbir Hussain A Ali Source Type: research
Antibiotic resistance in < em > Campylobacter jejuni < /em > and < em > Campylobacter coli: < /em > significant contribution of an RND type efflux pump in erythromycin resistance
In this study, we aimed to determine the antibiotic resistance status of Campylobacter spp. isolated from human infections in our region, including the role of mechanisms involved in erythromycin resistance. Standard methods were used for the isolation, identification and antibiotic susceptibility testing of Campylobacter spp. isolates. Erythromycin-resistant mutants were selected from erythromycin-susceptible clinical isolates, and the erythromycin resistance mechanisms were investigated phenotypically by determining the erythromycin MICs of isolates in the presence and absence of the resistance nodulation cell division (...
Source: Journal of Chemotherapy - October 13, 2023 Category: Cancer & Oncology Authors: Beyza Oncel Ufuk Hasdemir Burak Aksu Spyros Pournaras Source Type: research
Varicella zoster virus reactivation reported with isatuximab use
J Chemother. 2023 Oct 6:1-4. doi: 10.1080/1120009X.2023.2266201. Online ahead of print.ABSTRACTIsatuximab is a CD38-directed antibody indicated for the treatment of relapsed or refractory multiple myeloma. The Division of Pharmacovigilance at the U.S. Food and Drug Administration (FDA) reviewed case reports from postmarketing sources, including the FDA Adverse Event Reporting System (FAERS), PubMed, and Embase, to investigate a potential association between isatuximab and the risk of varicella zoster virus (VZV) reactivation. We identified 20 reports of which 15 met our case definition and causality criteria. All 15 patien...
Source: Journal of Chemotherapy - October 6, 2023 Category: Cancer & Oncology Authors: Michelle Nadeau Nguyen Gra ça M Dores Afrouz Nayernama S Christopher Jones Source Type: research
Astaxanthin induces autophagy and apoptosis in murine melanoma B16F10-Nex2 cells and exhibits antitumor activity < em > in vivo < /em >
In conclusion, AST has cytotoxic effect in melanoma cells and inhibits cell migration and invasion, indicating a promising use in cancer treatment.PMID:37800867 | DOI:10.1080/1120009X.2023.2264585 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - October 6, 2023 Category: Cancer & Oncology Authors: Fernanda Fernandes Miranda da Cunha Angela Pedroso Tonon Fabricio Machado Luis Rodolpho Travassos Nathalia Grazzia Jo ão Fernando Possatto Agnes Kobayashi Calvo de Sant'ana Rayssa de Mello Lopes Tiago Rodrigues Danilo Ciccone Miguel Fernanda Ramos Gadelh Source Type: research
