Impact of a hospital sepsis management protocol on the selection of empirical antibiotics in infectious disease consultations
This study highlights the significance of using a structured protocol to attain appropriate empirical treatment for patients suspected of sepsis, even in a setting where IDC is readily available.PMID:38131316 | DOI:10.1080/1120009X.2023.2296146 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - December 22, 2023 Category: Cancer & Oncology Authors: Asl ı Özden B üşra Dalgıç Mervenur Demir G ülşen Hazırolan Ömrüm Uzun G ökhan Metan Source Type: research
Emerging role of competing endogenous RNA in lung cancer drug resistance
J Chemother. 2023 Dec 20:1-20. doi: 10.1080/1120009X.2023.2294582. Online ahead of print.ABSTRACTLung cancer remains one of the most common malignant cancers worldwide, and its survival rate is extremely low. Chemotherapy, the mainstay of lung cancer treatment, is not as effective as it could be due to the development of cellular resistance. The molecular mechanisms of drug resistance in lung cancer remain to be elucidated. Accumulating evidence suggests that ceRNAs are involved in various carcinogenesis and development. CeRNA is a transcript that regulates each other through competition with miRNA. However, the relationsh...
Source: Journal of Chemotherapy - December 21, 2023 Category: Cancer & Oncology Authors: Shijie Wu Ting Luo Xiaoyong Lei Xiaoyan Yang Source Type: research
Neutralizing monoclonal antibodies for the prevention of severe COVID-19: a retrospective study during Omicron BA.1 variant surge
J Chemother. 2023 Dec 14:1-8. doi: 10.1080/1120009X.2023.2289269. Online ahead of print.ABSTRACTAmong treatment options for Coronavirus disease 2019 (COVID-19), monoclonal antibodies (mAbs) showed to be effective in preventing disease progression, but real-world data during the Omicron variant surge are still lacking. Multicentre retrospective study evaluating the effectiveness of sotrovimab and casirivimab-imdevimab in fragile patients with mild SARS-CoV-2 infection between November 2021 and March 2022. Unfavourable outcome was defined as increased need for oxygen supplementation and/or death. Of 268 study-participants, 1...
Source: Journal of Chemotherapy - December 14, 2023 Category: Cancer & Oncology Authors: Claudia Bartalucci Alessandro Limongelli Laura Ambra Nicolini Marta Ponzano Stefania Tigano Sara Tita Farinella Giuliana Carrega Gemma Malerba Federica Magn è Elisa Balletto Daniele Roberto Giacobbe Giovanni Riccio Giovanni Cenderello Lucia Taramasso Bia Source Type: research
Are small lymphocytic lymphoma and chronic lymphocytic leukemia the same disease? The unsolved dilemma
J Chemother. 2023 Dec 11:1-5. doi: 10.1080/1120009X.2023.2290349. Online ahead of print.ABSTRACTThe management of small lymphocytic lymphoma (SLL) as chronic lymphocytic leukemia (CLL) or an indolent non-Hodgkin lymphoma is highly debated. In this single-center, real-life study, 38 SLL patients managed between 2008 and 2022 were evaluated. Overall, 26/38 cases (68.4%) needed treatment and all but one received CLL concordant therapy, including BR (9/38 cases), fludarabine, cyclophosphamide, rituximab (5/38 cases), rituximab and chlorambucil (4/38 cases), BTK inhibitors (7/38 cases) and steroid (1 case with immune thrombocyt...
Source: Journal of Chemotherapy - December 11, 2023 Category: Cancer & Oncology Authors: Emanuele Cencini Natale Calomino Anna Sicuranza Alessandro Gozzetti Alberto Fabbri Monica Bocchia Source Type: research
Mpox vaccination and treatment: a systematic review
J Chemother. 2023 Dec 9:1-25. doi: 10.1080/1120009X.2023.2289270. Online ahead of print.ABSTRACTThe Human monkeypox virus (mpox) belongs to the Poxviridae family, characterized by double-stranded DNA. A 2022 outbreak, notably prevalent among men who have sex with men, was confirmed by the World Health Organization. To understand shifting prevalence patterns and clinical manifestations, we conducted a systematic review of recent animal and human studies. We comprehensively searched PubMed, Scopus, Web of Science, Cochrane Library, and Clinicaltrials.gov, reviewing 69 relevant articles from 4,342 screened records. Our analys...
Source: Journal of Chemotherapy - December 9, 2023 Category: Cancer & Oncology Authors: Arvin Eslami Shaya Alimoghadam Sahar Khoshravesh Mahsa Shiriani Rojina Alimoghadam Ilad Alavi Darazam Source Type: research
The relationship between statin administration timing and survival outcomes in patients with cancer receiving immune checkpoint blockade
CONCLUSIONS: These findings suggest that initiating statin therapy after the initiation of ICB, regardless of indication, is associated with improved patient prognosis.PMID:38062978 | DOI:10.1080/1120009X.2023.2290348 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - December 8, 2023 Category: Cancer & Oncology Authors: Zihan Wang Xin Ya See Cho-Hung Chiang Yu-Cheng Chang Yuan Ping Hsia Cho-Hsien Chiang Cheng-Ming Peng Cho-Han Chiang Source Type: research
