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Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research

Insights into the mediation of Ca < sup > 2+ < /sup > signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
J Cell Commun Signal. 2023 Sep 13. doi: 10.1007/s12079-023-00783-6. Online ahead of print.ABSTRACTLatroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and release of dopamine. Hererin, the involvement of Ca2+ signaling in the effects of LETX-VI on dopamine was systematically investigated, using PC12 cells as a neuron model. LETX-VI was shown to promote dopamine release from PC12 cells both in the presence and absence of extracellular Ca2+; however the presence of extracellular Ca2+ was favorable for enhancing the promoting effects of LETX-VI on dopamine, because L...
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Zhixiang Lei Haiyan Wang Yiwen Zhai Minglu Sun Si Chen Panfeng Yin Xianchun Wang Source Type: research

Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway
In conclusion, metformin combined with rapamycin decreased proteinuria, improved renal fibrosis and podocyte autophagy via AMPK/mTOR pathway in IMN rats. The metformin and rapamycin decreased proteinuria and inproved renal fibrosis in IMN model rats.PMID:37702819 | DOI:10.1007/s12079-023-00781-8 (Source: Journal of Cell Communication and Signaling)
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Meichen Ma Yue Pan Yue Zhang Mei Yang Ying Xi Baoxu Lin Wudi Hao Jianhua Liu Lina Wu Yong Liu Xiaosong Qin Source Type: research

Insights into the mediation of Ca < sup > 2+ < /sup > signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
J Cell Commun Signal. 2023 Sep 13. doi: 10.1007/s12079-023-00783-6. Online ahead of print.ABSTRACTLatroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and release of dopamine. Hererin, the involvement of Ca2+ signaling in the effects of LETX-VI on dopamine was systematically investigated, using PC12 cells as a neuron model. LETX-VI was shown to promote dopamine release from PC12 cells both in the presence and absence of extracellular Ca2+; however the presence of extracellular Ca2+ was favorable for enhancing the promoting effects of LETX-VI on dopamine, because L...
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Zhixiang Lei Haiyan Wang Yiwen Zhai Minglu Sun Si Chen Panfeng Yin Xianchun Wang Source Type: research

Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway
In conclusion, metformin combined with rapamycin decreased proteinuria, improved renal fibrosis and podocyte autophagy via AMPK/mTOR pathway in IMN rats. The metformin and rapamycin decreased proteinuria and inproved renal fibrosis in IMN model rats.PMID:37702819 | DOI:10.1007/s12079-023-00781-8 (Source: Journal of Cell Communication and Signaling)
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Meichen Ma Yue Pan Yue Zhang Mei Yang Ying Xi Baoxu Lin Wudi Hao Jianhua Liu Lina Wu Yong Liu Xiaosong Qin Source Type: research

Insights into the mediation of Ca < sup > 2+ < /sup > signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
J Cell Commun Signal. 2023 Sep 13. doi: 10.1007/s12079-023-00783-6. Online ahead of print.ABSTRACTLatroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and release of dopamine. Hererin, the involvement of Ca2+ signaling in the effects of LETX-VI on dopamine was systematically investigated, using PC12 cells as a neuron model. LETX-VI was shown to promote dopamine release from PC12 cells both in the presence and absence of extracellular Ca2+; however the presence of extracellular Ca2+ was favorable for enhancing the promoting effects of LETX-VI on dopamine, because L...
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Zhixiang Lei Haiyan Wang Yiwen Zhai Minglu Sun Si Chen Panfeng Yin Xianchun Wang Source Type: research