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Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells
This study demonstrates that expression of the PAR2 gene in human colon adenocarcinoma tissue samples was the highest among 32 different cancer types (n = 10,989), and higher in colon adenocarcinoma tissues (n = 331) than normal colon tissues (n = 308), revealing an association between PAR2 expression and human colon cancer. HT29 cells are a human colorectal adenocarcinoma cell line that is sensitive to the chemotherapeutic drug doxorubicin and also expresses PAR2. We find that PAR2 activation in HT29 cells, either by an endogenous protease agonist (trypsin) or an exogenous peptide agonist (2f-LIGRL-NH2), significantly red...
Source: Journal of Cell Communication and Signaling - November 22, 2023 Category: Molecular Biology Authors: Himani Shah Timothy A Hill Junxian Lim David P Fairlie Source Type: research

Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells
This study demonstrates that expression of the PAR2 gene in human colon adenocarcinoma tissue samples was the highest among 32 different cancer types (n = 10,989), and higher in colon adenocarcinoma tissues (n = 331) than normal colon tissues (n = 308), revealing an association between PAR2 expression and human colon cancer. HT29 cells are a human colorectal adenocarcinoma cell line that is sensitive to the chemotherapeutic drug doxorubicin and also expresses PAR2. We find that PAR2 activation in HT29 cells, either by an endogenous protease agonist (trypsin) or an exogenous peptide agonist (2f-LIGRL-NH2), significantly red...
Source: Journal of Cell Communication and Signaling - November 22, 2023 Category: Molecular Biology Authors: Himani Shah Timothy A Hill Junxian Lim David P Fairlie Source Type: research

Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells
This study demonstrates that expression of the PAR2 gene in human colon adenocarcinoma tissue samples was the highest among 32 different cancer types (n = 10,989), and higher in colon adenocarcinoma tissues (n = 331) than normal colon tissues (n = 308), revealing an association between PAR2 expression and human colon cancer. HT29 cells are a human colorectal adenocarcinoma cell line that is sensitive to the chemotherapeutic drug doxorubicin and also expresses PAR2. We find that PAR2 activation in HT29 cells, either by an endogenous protease agonist (trypsin) or an exogenous peptide agonist (2f-LIGRL-NH2), significantly red...
Source: Journal of Cell Communication and Signaling - November 22, 2023 Category: Molecular Biology Authors: Himani Shah Timothy A Hill Junxian Lim David P Fairlie Source Type: research

Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells
This study demonstrates that expression of the PAR2 gene in human colon adenocarcinoma tissue samples was the highest among 32 different cancer types (n = 10,989), and higher in colon adenocarcinoma tissues (n = 331) than normal colon tissues (n = 308), revealing an association between PAR2 expression and human colon cancer. HT29 cells are a human colorectal adenocarcinoma cell line that is sensitive to the chemotherapeutic drug doxorubicin and also expresses PAR2. We find that PAR2 activation in HT29 cells, either by an endogenous protease agonist (trypsin) or an exogenous peptide agonist (2f-LIGRL-NH2), significantly red...
Source: Journal of Cell Communication and Signaling - November 22, 2023 Category: Molecular Biology Authors: Himani Shah Timothy A Hill Junxian Lim David P Fairlie Source Type: research

Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer
J Cell Commun Signal. 2023 Nov 20. doi: 10.1007/s12079-023-00793-4. Online ahead of print.ABSTRACTAberrant canonical Wnt signaling is a hallmark of colon cancer. The TP53 tumor suppressor gene is altered in many solid tumors, including colorectal cancer, resulting in mutant versions of p53 (mut-p53) that lose their tumor suppressor capacities and acquire new-oncogenic functions (GOFs) critical for disease progression. Although the mechanisms related to mut-p53 GOF have been explored extensively, the relevance of mut-p53 in the canonical Wnt pathway is not well defined. This work investigated the influence of mut-p53 compar...
Source: Journal of Cell Communication and Signaling - November 20, 2023 Category: Molecular Biology Authors: Eduardo Alvarado-Ortiz Elizabeth Ortiz-S ánchez Miguel Angel Sarabia-S ánchez Karen Griselda de la Cruz-L ópez Alejandro Garc ía-Carrancá Martha Robles-Flores Source Type: research

GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
J Cell Commun Signal. 2023 Nov 19. doi: 10.1007/s12079-023-00792-5. Online ahead of print.ABSTRACTG protein-coupled receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes ranging from development to cancer. In our earlier study, we reported that GPR56 is expressed heterogeneously in glioblastoma (GBM) and is involved in the mesenchymal transition, making it a promising therapeutic target (Ganesh et al., 2022). Despite its important role in cancer, its mechanism of action or signaling is not completely understood. Thus, based on transcriptomic, proteomic, and phosphoproteomic ...
Source: Journal of Cell Communication and Signaling - November 19, 2023 Category: Molecular Biology Authors: Raksha A Ganesh Krishnan Venkataraman Ravi Sirdeshmukh Source Type: research

GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
J Cell Commun Signal. 2023 Nov 19. doi: 10.1007/s12079-023-00792-5. Online ahead of print.ABSTRACTG protein-coupled receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes ranging from development to cancer. In our earlier study, we reported that GPR56 is expressed heterogeneously in glioblastoma (GBM) and is involved in the mesenchymal transition, making it a promising therapeutic target (Ganesh et al., 2022). Despite its important role in cancer, its mechanism of action or signaling is not completely understood. Thus, based on transcriptomic, proteomic, and phosphoproteomic ...
Source: Journal of Cell Communication and Signaling - November 19, 2023 Category: Molecular Biology Authors: Raksha A Ganesh Krishnan Venkataraman Ravi Sirdeshmukh Source Type: research

Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions
J Cell Commun Signal. 2023 Nov 16. doi: 10.1007/s12079-023-00794-3. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are multipotent, self-renewing stromal cells found in a variety of adult tissues. MSCs possess a remarkable ability to migrate towards tumor sites, known as homing. This homing process is mediated by various factors, including chemokines, growth factors, and extracellular matrix components present in the tumor microenvironment. MSCs release extracellular vesicles known as exosomes (MSC-Exos), which have been suggested to serve a key role in mediating a wide variety of MSC activities. Through cell-...
Source: Journal of Cell Communication and Signaling - November 16, 2023 Category: Molecular Biology Authors: Babak Jahangiri Mohammad Khalaj-Kondori Elahe Asadollahi Ali Kian Saei Majid Sadeghizadeh Source Type: research

Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions
J Cell Commun Signal. 2023 Nov 16. doi: 10.1007/s12079-023-00794-3. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are multipotent, self-renewing stromal cells found in a variety of adult tissues. MSCs possess a remarkable ability to migrate towards tumor sites, known as homing. This homing process is mediated by various factors, including chemokines, growth factors, and extracellular matrix components present in the tumor microenvironment. MSCs release extracellular vesicles known as exosomes (MSC-Exos), which have been suggested to serve a key role in mediating a wide variety of MSC activities. Through cell-...
Source: Journal of Cell Communication and Signaling - November 16, 2023 Category: Molecular Biology Authors: Babak Jahangiri Mohammad Khalaj-Kondori Elahe Asadollahi Ali Kian Saei Majid Sadeghizadeh Source Type: research

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction
J Cell Commun Signal. 2023 Oct 25. doi: 10.1007/s12079-023-00788-1. Online ahead of print.ABSTRACTInterleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses a nuclear localization signal and a homeodomain (a structure resembling a helix-turn-helix) that can bind to nuclear chromatin. Research has revealed that IL-33 can function as a nuclear factor to regulate various biological processes. This review discusses the cellular localization, functional effects, and immune regulation of full length IL-33 (FLIL-33), cytokine IL-33 (sIL-33) and nuclear IL-33 (nIL-33)....
Source: Journal of Cell Communication and Signaling - October 25, 2023 Category: Molecular Biology Authors: Zengbin Wang Nanhong Tang Source Type: research

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction
J Cell Commun Signal. 2023 Oct 25. doi: 10.1007/s12079-023-00788-1. Online ahead of print.ABSTRACTInterleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses a nuclear localization signal and a homeodomain (a structure resembling a helix-turn-helix) that can bind to nuclear chromatin. Research has revealed that IL-33 can function as a nuclear factor to regulate various biological processes. This review discusses the cellular localization, functional effects, and immune regulation of full length IL-33 (FLIL-33), cytokine IL-33 (sIL-33) and nuclear IL-33 (nIL-33)....
Source: Journal of Cell Communication and Signaling - October 25, 2023 Category: Molecular Biology Authors: Zengbin Wang Nanhong Tang Source Type: research

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction
J Cell Commun Signal. 2023 Oct 25. doi: 10.1007/s12079-023-00788-1. Online ahead of print.ABSTRACTInterleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses a nuclear localization signal and a homeodomain (a structure resembling a helix-turn-helix) that can bind to nuclear chromatin. Research has revealed that IL-33 can function as a nuclear factor to regulate various biological processes. This review discusses the cellular localization, functional effects, and immune regulation of full length IL-33 (FLIL-33), cytokine IL-33 (sIL-33) and nuclear IL-33 (nIL-33)....
Source: Journal of Cell Communication and Signaling - October 25, 2023 Category: Molecular Biology Authors: Zengbin Wang Nanhong Tang Source Type: research

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction
J Cell Commun Signal. 2023 Oct 25. doi: 10.1007/s12079-023-00788-1. Online ahead of print.ABSTRACTInterleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses a nuclear localization signal and a homeodomain (a structure resembling a helix-turn-helix) that can bind to nuclear chromatin. Research has revealed that IL-33 can function as a nuclear factor to regulate various biological processes. This review discusses the cellular localization, functional effects, and immune regulation of full length IL-33 (FLIL-33), cytokine IL-33 (sIL-33) and nuclear IL-33 (nIL-33)....
Source: Journal of Cell Communication and Signaling - October 25, 2023 Category: Molecular Biology Authors: Zengbin Wang Nanhong Tang Source Type: research

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction
J Cell Commun Signal. 2023 Oct 25. doi: 10.1007/s12079-023-00788-1. Online ahead of print.ABSTRACTInterleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses a nuclear localization signal and a homeodomain (a structure resembling a helix-turn-helix) that can bind to nuclear chromatin. Research has revealed that IL-33 can function as a nuclear factor to regulate various biological processes. This review discusses the cellular localization, functional effects, and immune regulation of full length IL-33 (FLIL-33), cytokine IL-33 (sIL-33) and nuclear IL-33 (nIL-33)....
Source: Journal of Cell Communication and Signaling - October 25, 2023 Category: Molecular Biology Authors: Zengbin Wang Nanhong Tang Source Type: research

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction
J Cell Commun Signal. 2023 Oct 25. doi: 10.1007/s12079-023-00788-1. Online ahead of print.ABSTRACTInterleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses a nuclear localization signal and a homeodomain (a structure resembling a helix-turn-helix) that can bind to nuclear chromatin. Research has revealed that IL-33 can function as a nuclear factor to regulate various biological processes. This review discusses the cellular localization, functional effects, and immune regulation of full length IL-33 (FLIL-33), cytokine IL-33 (sIL-33) and nuclear IL-33 (nIL-33)....
Source: Journal of Cell Communication and Signaling - October 25, 2023 Category: Molecular Biology Authors: Zengbin Wang Nanhong Tang Source Type: research