Farewell Springer … Hello Wiley : The tale of an academic scientific periodical -"20 years later" the Journal of Cell Communication and Signaling
J Cell Commun Signal. 2023 Dec;17(4):1123-1129. doi: 10.1007/s12079-023-00796-1.ABSTRACTAcademic publishing is the support for dissemination of research findings that constitute the grounds upon which new orientations and improvements are based on sharing breaking ideas, critical analyses of data, and argumentations that sustain the development of collaborative research projects. The wide diffusion of new scientific findings is pivotal to the progress of medical sciences, a salient feature of human societal fullness and intellectual welfare. In a practical way, the value of academic publishing can be ascertained by its cap...
Source: Journal of Cell Communication and Signaling - December 7, 2023 Category: Molecular Biology Authors: Bernard Perbal Source Type: research

Farewell Springer … Hello Wiley : The tale of an academic scientific periodical -"20 years later" the Journal of Cell Communication and Signaling
J Cell Commun Signal. 2023 Dec;17(4):1123-1129. doi: 10.1007/s12079-023-00796-1.ABSTRACTAcademic publishing is the support for dissemination of research findings that constitute the grounds upon which new orientations and improvements are based on sharing breaking ideas, critical analyses of data, and argumentations that sustain the development of collaborative research projects. The wide diffusion of new scientific findings is pivotal to the progress of medical sciences, a salient feature of human societal fullness and intellectual welfare. In a practical way, the value of academic publishing can be ascertained by its cap...
Source: Journal of Cell Communication and Signaling - December 7, 2023 Category: Molecular Biology Authors: Bernard Perbal Source Type: research

Farewell Springer … Hello Wiley : The tale of an academic scientific periodical -"20 years later" the Journal of Cell Communication and Signaling
J Cell Commun Signal. 2023 Dec 7. doi: 10.1007/s12079-023-00796-1. Online ahead of print.ABSTRACTAcademic publishing is the support for dissemination of research findings that constitute the grounds upon which new orientations and improvements are based on sharing breaking ideas, critical analyses of data, and argumentations that sustain the development of collaborative research projects. The wide diffusion of new scientific findings is pivotal to the progress of medical sciences, a salient feature of human societal fullness and intellectual welfare. In a practical way, the value of academic publishing can be ascertained b...
Source: Journal of Cell Communication and Signaling - December 7, 2023 Category: Molecular Biology Authors: Bernard Perbal Source Type: research

Farewell Springer … Hello Wiley : The tale of an academic scientific periodical -"20 years later" the Journal of Cell Communication and Signaling
J Cell Commun Signal. 2023 Dec 7. doi: 10.1007/s12079-023-00796-1. Online ahead of print.ABSTRACTAcademic publishing is the support for dissemination of research findings that constitute the grounds upon which new orientations and improvements are based on sharing breaking ideas, critical analyses of data, and argumentations that sustain the development of collaborative research projects. The wide diffusion of new scientific findings is pivotal to the progress of medical sciences, a salient feature of human societal fullness and intellectual welfare. In a practical way, the value of academic publishing can be ascertained b...
Source: Journal of Cell Communication and Signaling - December 7, 2023 Category: Molecular Biology Authors: Bernard Perbal Source Type: research

Farewell Springer … Hello Wiley : The tale of an academic scientific periodical -"20 years later" the Journal of Cell Communication and Signaling
J Cell Commun Signal. 2023 Dec 7. doi: 10.1007/s12079-023-00796-1. Online ahead of print.ABSTRACTAcademic publishing is the support for dissemination of research findings that constitute the grounds upon which new orientations and improvements are based on sharing breaking ideas, critical analyses of data, and argumentations that sustain the development of collaborative research projects. The wide diffusion of new scientific findings is pivotal to the progress of medical sciences, a salient feature of human societal fullness and intellectual welfare. In a practical way, the value of academic publishing can be ascertained b...
Source: Journal of Cell Communication and Signaling - December 7, 2023 Category: Molecular Biology Authors: Bernard Perbal Source Type: research

Use and application of organ-on-a-chip platforms in cancer research
J Cell Commun Signal. 2023 Nov 30. doi: 10.1007/s12079-023-00790-7. Online ahead of print.ABSTRACTTumors are a major cause of death worldwide, and much effort has been made to develop appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the critical features of cancer. The development of organ-on-a-chip models has enabled the integration of organoids, microfluidics, tissue engineering, biomaterials research, and microfabrication, offering conditions that mimic tumor physiology. Three-dimensional in vitro human tumor models that have been established as organ-on-a-chip models contain m...
Source: Journal of Cell Communication and Signaling - November 30, 2023 Category: Molecular Biology Authors: Yifan Yu TingTing Zhou Liu Cao Source Type: research

Use and application of organ-on-a-chip platforms in cancer research
J Cell Commun Signal. 2023 Nov 30. doi: 10.1007/s12079-023-00790-7. Online ahead of print.ABSTRACTTumors are a major cause of death worldwide, and much effort has been made to develop appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the critical features of cancer. The development of organ-on-a-chip models has enabled the integration of organoids, microfluidics, tissue engineering, biomaterials research, and microfabrication, offering conditions that mimic tumor physiology. Three-dimensional in vitro human tumor models that have been established as organ-on-a-chip models contain m...
Source: Journal of Cell Communication and Signaling - November 30, 2023 Category: Molecular Biology Authors: Yifan Yu TingTing Zhou Liu Cao Source Type: research

Use and application of organ-on-a-chip platforms in cancer research
J Cell Commun Signal. 2023 Nov 30. doi: 10.1007/s12079-023-00790-7. Online ahead of print.ABSTRACTTumors are a major cause of death worldwide, and much effort has been made to develop appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the critical features of cancer. The development of organ-on-a-chip models has enabled the integration of organoids, microfluidics, tissue engineering, biomaterials research, and microfabrication, offering conditions that mimic tumor physiology. Three-dimensional in vitro human tumor models that have been established as organ-on-a-chip models contain m...
Source: Journal of Cell Communication and Signaling - November 30, 2023 Category: Molecular Biology Authors: Yifan Yu TingTing Zhou Liu Cao Source Type: research

Use and application of organ-on-a-chip platforms in cancer research
J Cell Commun Signal. 2023 Nov 30. doi: 10.1007/s12079-023-00790-7. Online ahead of print.ABSTRACTTumors are a major cause of death worldwide, and much effort has been made to develop appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the critical features of cancer. The development of organ-on-a-chip models has enabled the integration of organoids, microfluidics, tissue engineering, biomaterials research, and microfabrication, offering conditions that mimic tumor physiology. Three-dimensional in vitro human tumor models that have been established as organ-on-a-chip models contain m...
Source: Journal of Cell Communication and Signaling - November 30, 2023 Category: Molecular Biology Authors: Yifan Yu TingTing Zhou Liu Cao Source Type: research

Use and application of organ-on-a-chip platforms in cancer research
J Cell Commun Signal. 2023 Nov 30. doi: 10.1007/s12079-023-00790-7. Online ahead of print.ABSTRACTTumors are a major cause of death worldwide, and much effort has been made to develop appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the critical features of cancer. The development of organ-on-a-chip models has enabled the integration of organoids, microfluidics, tissue engineering, biomaterials research, and microfabrication, offering conditions that mimic tumor physiology. Three-dimensional in vitro human tumor models that have been established as organ-on-a-chip models contain m...
Source: Journal of Cell Communication and Signaling - November 30, 2023 Category: Molecular Biology Authors: Yifan Yu TingTing Zhou Liu Cao Source Type: research

Use and application of organ-on-a-chip platforms in cancer research
J Cell Commun Signal. 2023 Nov 30. doi: 10.1007/s12079-023-00790-7. Online ahead of print.ABSTRACTTumors are a major cause of death worldwide, and much effort has been made to develop appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the critical features of cancer. The development of organ-on-a-chip models has enabled the integration of organoids, microfluidics, tissue engineering, biomaterials research, and microfabrication, offering conditions that mimic tumor physiology. Three-dimensional in vitro human tumor models that have been established as organ-on-a-chip models contain m...
Source: Journal of Cell Communication and Signaling - November 30, 2023 Category: Molecular Biology Authors: Yifan Yu TingTing Zhou Liu Cao Source Type: research

miRNAs as short non-coding RNAs in regulating doxorubicin resistance
J Cell Commun Signal. 2023 Nov 29. doi: 10.1007/s12079-023-00789-0. Online ahead of print.ABSTRACTThe treatment of cancer patients has been prohibited by chemoresistance. Doxorubicin (DOX) is an anti-tumor compound disrupting proliferation and triggering cell cycle arrest via inhibiting activity of topoisomerase I and II. miRNAs are endogenous RNAs localized in cytoplasm to reduce gene level. Abnormal expression of miRNAs changes DOX cytotoxicity. Overexpression of tumor-promoting miRNAs induces DOX resistance, while tumor-suppressor miRNAs inhibit DOX resistance. The miRNA-mediated regulation of cell death and hallmarks o...
Source: Journal of Cell Communication and Signaling - November 29, 2023 Category: Molecular Biology Authors: Sepideh Mirzaei Mahshid Deldar Abad Paskeh Farhad Adhami Moghadam Maliheh Entezari Zeinab Khazaei Koohpar Elahe Sadat Hejazi Shamin Rezaei Amirabbas Kakavand Maryam Aboutalebi Mohammad Arad Zandieh Romina Rajabi Shokooh Salimimoghadam Afshin Taheriazam Me Source Type: research

miRNAs as short non-coding RNAs in regulating doxorubicin resistance
J Cell Commun Signal. 2023 Nov 29. doi: 10.1007/s12079-023-00789-0. Online ahead of print.ABSTRACTThe treatment of cancer patients has been prohibited by chemoresistance. Doxorubicin (DOX) is an anti-tumor compound disrupting proliferation and triggering cell cycle arrest via inhibiting activity of topoisomerase I and II. miRNAs are endogenous RNAs localized in cytoplasm to reduce gene level. Abnormal expression of miRNAs changes DOX cytotoxicity. Overexpression of tumor-promoting miRNAs induces DOX resistance, while tumor-suppressor miRNAs inhibit DOX resistance. The miRNA-mediated regulation of cell death and hallmarks o...
Source: Journal of Cell Communication and Signaling - November 29, 2023 Category: Molecular Biology Authors: Sepideh Mirzaei Mahshid Deldar Abad Paskeh Farhad Adhami Moghadam Maliheh Entezari Zeinab Khazaei Koohpar Elahe Sadat Hejazi Shamin Rezaei Amirabbas Kakavand Maryam Aboutalebi Mohammad Arad Zandieh Romina Rajabi Shokooh Salimimoghadam Afshin Taheriazam Me Source Type: research

Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells
This study demonstrates that expression of the PAR2 gene in human colon adenocarcinoma tissue samples was the highest among 32 different cancer types (n = 10,989), and higher in colon adenocarcinoma tissues (n = 331) than normal colon tissues (n = 308), revealing an association between PAR2 expression and human colon cancer. HT29 cells are a human colorectal adenocarcinoma cell line that is sensitive to the chemotherapeutic drug doxorubicin and also expresses PAR2. We find that PAR2 activation in HT29 cells, either by an endogenous protease agonist (trypsin) or an exogenous peptide agonist (2f-LIGRL-NH2), significantly red...
Source: Journal of Cell Communication and Signaling - November 22, 2023 Category: Molecular Biology Authors: Himani Shah Timothy A Hill Junxian Lim David P Fairlie Source Type: research

Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells
This study demonstrates that expression of the PAR2 gene in human colon adenocarcinoma tissue samples was the highest among 32 different cancer types (n = 10,989), and higher in colon adenocarcinoma tissues (n = 331) than normal colon tissues (n = 308), revealing an association between PAR2 expression and human colon cancer. HT29 cells are a human colorectal adenocarcinoma cell line that is sensitive to the chemotherapeutic drug doxorubicin and also expresses PAR2. We find that PAR2 activation in HT29 cells, either by an endogenous protease agonist (trypsin) or an exogenous peptide agonist (2f-LIGRL-NH2), significantly red...
Source: Journal of Cell Communication and Signaling - November 22, 2023 Category: Molecular Biology Authors: Himani Shah Timothy A Hill Junxian Lim David P Fairlie Source Type: research