Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway

In conclusion, metformin combined with rapamycin decreased proteinuria, improved renal fibrosis and podocyte autophagy via AMPK/mTOR pathway in IMN rats. The metformin and rapamycin decreased proteinuria and inproved renal fibrosis in IMN model rats.PMID:37702819 | DOI:10.1007/s12079-023-00781-8

Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Meichen Ma Yue Pan Yue Zhang Mei Yang Ying Xi Baoxu Lin Wudi Hao Jianhua Liu Lina Wu Yong Liu Xiaosong Qin Source Type: research