Tecovirimat for Mpox —Promise and Limitations
In this issue of JAMA Internal Medicine, Aldred et al report on a critical clinical question amid the recent mpox outbreak: does early tecovirimat treatment improve outcomes in people with HIV? The authors conducted a matched case-cohort study in 4 hospitals in Atlanta, Georgia. The exposed group included those who received tecovirimat within 7 days of diagnosis, and the unexposed group were those who did not receive tecovirimat or received it after 7 days. Roughly 5.4% of the 56 treated and 26.8% of the 56 untreated or late-treated patients progressed, representing an odds ratio of 11.0 (95% CI, 1.4-85.1) for progression ...
Source: JAMA Internal Medicine - January 8, 2024 Category: Internal Medicine Source Type: research
Lifetime Gained With Cancer Screening —Reply
In Reply The starting point for our study was the promotion of cancer screening as lifesaving —a powerful claim. However, our study findings showed that this statement is not backed by trial evidence. As we stated in the conclusion of our meta-analysis, we do not advocate for abandoning all screening; rather, we find it important to call for moderation and fact-based information instead of promising a longer life with cancer screening. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - January 2, 2024 Category: Internal Medicine Source Type: research
Lifetime Gained With Cancer Screening
To the Editor In a recent meta-analysis, Bretthauer et al addressed the question of whether and to what extent the established cancer screening approaches prolong lives. Their study suggests that claims that screening saves lives are not substantiated by the current best available evidence. However, the methods used by the authors are inadequate and the results are misleading for multiple reasons. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - January 2, 2024 Category: Internal Medicine Source Type: research
Lifetime Gained With Cancer Screening
To the Editor During the past 25 years, life expectancy of the world population increased by more than 5 years. The largest improvements were observed among low-income countries, according to public health measures. In high-income countries, the increase amounted to approximately 3.5 years or approximately 1300 days. This tremendous achievement occurred in an era of major innovations. Improved diagnostics, less-invasive interventions, new drugs, and many other advancements contributed. However, we risk disappointment when calculating how much any of these developments increased population life expectancy —most innovation...
Source: JAMA Internal Medicine - January 2, 2024 Category: Internal Medicine Source Type: research
Lifetime Gained With Cancer Screening
This article advances the discussion on this important and timely topic. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - January 2, 2024 Category: Internal Medicine Source Type: research
Advance Provision of Mifepristone and Misoprostol via Online Telemedicine in the US
This cross-sectional study examines trends in the demand and characteristics and motivations of individuals who requested advance provision of abortion medications. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - January 2, 2024 Category: Internal Medicine Source Type: research
Automated External Defibrillator Use After Out-of-Hospital Cardiac Arrest at Recreational Facilities
This cohort study examines bystander automated external defibrillator (AED) application and survival outcomes for out-of-hospital cardiac arrest at recreational facilities in US states with and without AED legislation. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - January 2, 2024 Category: Internal Medicine Source Type: research
Automated External Defibrillators Are Only Effective If Put to Use
In their cohort study in this issue of JAMA Internal Medicine, Kolkailah et al found that rates of bystander automated external defibrillator (AED) use were similarly low in both states that mandate and those that do not mandate such devices in recreational facilities: 19% vs 18%. The fact that cardiac arrests with ventricular tachycardia or ventricular fibrillation rhythms have significantly better odds of survival when early cardiopulmonary resuscitation is performed has likely motivated policies to expand AED availability. However, availability alone does not guarantee appropriate use by bystanders. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - January 2, 2024 Category: Internal Medicine Source Type: research
Weakness and Syncope After Prolonged Diarrhea
This case report presents the electrocardiogram findings of a patient in their 70s history of hypertension, chronic kidney failure, and prolonged diarrhea who presented for repeated episodes of weakness and syncope. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - January 2, 2024 Category: Internal Medicine Source Type: research
JAMA Internal Medicine
Mission Statement: To advance the equitable, person-centered, and evidence-based practice of internal medicine through publication of scientifically rigorous, innovative, and inclusive research, review, and commentary that informs dialogue and action with clinical, public health, and policy impact. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - January 1, 2024 Category: Internal Medicine Source Type: research
Effect of an Intensive Food-as-Medicine Program on Health and Health Care Use
This randomized clinical trial examines whether an intensive food-as-medicine program can improve glycemic control and ,1rengagement with preventive health care compared with usual care among adults with diabetes and food insecurity. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - December 26, 2023 Category: Internal Medicine Source Type: research
Food for Thought —Include Controls in Policy Evaluations
Food insecurity and poor diet may play a role in worsening many chronic diseases including diabetes, hypertension, and congestive heart failure. Thus, providing medically tailored meals or food as medicine for patients could be an effective and safe intervention. The randomized clinical trial by Doyle et al randomly assigned 230 patients with uncontrolled type 2 diabetes and food insecurity to receive healthy groceries for 10 meals per week for the entire household for 6 months and compared them with 235 patients who were placed on a wait list and received the food intervention after 6 months. The hemoglobin A1c level impr...
Source: JAMA Internal Medicine - December 26, 2023 Category: Internal Medicine Source Type: research
Errors In Methods
This article was corrected online. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - December 26, 2023 Category: Internal Medicine Source Type: research
Error in Funding Information
This article was corrected online. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - December 26, 2023 Category: Internal Medicine Source Type: research
A Young Pregnant Person With Old Myocardial Infarction
This case report presents the electrocardiogram findings of a pregnant patient in their 30s with a family history of hypertrophic obstructive cardiomyopathy. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - December 26, 2023 Category: Internal Medicine Source Type: research
