Etiological analysis of 167 cases of drug-resistant epilepsy in children
ConclusionsMore than half of children with DRE have a distinct underlying cause, predominantly attributed to structural factors, followed by genetic factors. Genetic etiology primarily manifests at an early age, especially among children aged less than one year. This underscores the need for proactive enhancements in genetic testing to unveil the underlying causes and subsequently guide treatment protocols. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 13, 2024 Category: Pediatrics Source Type: research
Nursing management of patients dealing with spina bifida: from the prenatal diagnosis to adulthood / nursing intervention for the improvement of the impact of urinary and fecal incontinence on the quality of life of people dealing with spina bifida
Conclusionurinary and fecal incontinence have, of course, an impact on the quality of life of people dealing with spina bifida. Nevertheless, we can observe that it is possible to improve the quality of life of these people, letting them feel confident enough to take part in social activities, through education from an incredibly young age, from 0 up to 25 years old and over, supplied by the medical staff and mostly by the parents (previously educated by the medical staff as well). (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 13, 2024 Category: Pediatrics Source Type: research
Exercise-induced bronchoconstriction, allergy and sports in children
AbstractExercise-induced bronchoconstriction (EIB) is characterized by the narrowing of airways during or after physical activity, leading to symptoms such as wheezing, coughing, and shortness of breath. Distinguishing between EIB and exercise-induced asthma (EIA) is essential, given their divergent therapeutic and prognostic considerations. EIB has been increasingly recognized as a significant concern in pediatric athletes. Moreover, studies indicate a noteworthy prevalence of EIB in children with atopic predispositions, unveiling a potential link between allergic sensitivities and exercise-induced respiratory symptoms, u...
Source: Italian Journal of Pediatrics - March 13, 2024 Category: Pediatrics Source Type: research
Critical illness-related corticosteroid insufficiency (CIRCI) in paediatric patients: a diagnostic and therapeutic challenge
AbstractCritical illness-related corticosteroid insufficiency or CIRCI is characterized by acute and life-threatening disfunction of hypothalamic –pituitary–adrenal (HPA) axis observed among intensive care unit- staying patients.It is associated with increased circulating levels of biological markers of inflammation and coagulation, morbidity, length of ICU stay, and mortality.Several mechanisms are involved in CIRCI pathogenesis: reduced CRH-stimulated ACTH release, peripheral resistance to glucocorticoids, altered cortisol synthesis, impaired cortisol-free fraction and bioavailability.Diagnostic and therapeutic manag...
Source: Italian Journal of Pediatrics - March 11, 2024 Category: Pediatrics Source Type: research
Critical illness-related corticosteroid insufficiency (CIRCI) in paediatric patients: a diagnostic and therapeutic challenge
Critical illness-related corticosteroid insufficiency or CIRCI is characterized by acute and life-threatening disfunction of hypothalamic –pituitary–adrenal (HPA) axis observed among intensive care unit- stayin... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 11, 2024 Category: Pediatrics Authors: Letteria Anna Morabito, Domenico Corica, Giorgia Pepe, Alessandra Li Pomi, Tommaso Aversa and Malgorzata Gabriela Wasniewska Tags: Review Source Type: research
Distribution of blood lead and cadmium levels in healthy children aged 0 to 18 years and analysis of related influencing factors in Henan, China: data findings from 2017 to 2022
This study was performed to analyze the BLLs and BCLs in heal... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 7, 2024 Category: Pediatrics Authors: Hui Yan, Bo Zhai, Ruiling Feng, Penggao Wang, Fang Yang and Yang Zhou Tags: Research Source Type: research
Healthcare migration in Italian paediatric haematology-oncology centres belonging to AIEOP
In Italy, there is a network of centres headed by the Italian Association of Pediatric Hematology and Oncology (AIEOP) for the diagnosis and treatment of paediatric cancers on almost the entire national territ... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 7, 2024 Category: Pediatrics Authors: Roberto Rondelli, Tamara Belotti, Riccardo Masetti, Franco Locatelli, Maura Massimino, Alessandra Biffi, Carlo Dufour, Franca Fagioli, Giuseppe Menna, Andrea Biondi, Claudio Favre, Marco Zecca, Nicola Santoro, Giovanna Russo, Silverio Perrotta, Andrea Pes Tags: Research Source Type: research
Respiratory syncytial virus-associated hospitalizations among children: an Italian retrospective observational study
Respiratory syncytial virus (RSV), a single-stranded RNA virus, is a leading cause of hospitalization in infants, especially ≤ 2 months of life. In the light new immunization strategies adoption, we described ... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 7, 2024 Category: Pediatrics Authors: Francesca Fortunato, Angelo Campanozzi, Gianfranco Maffei, Fabio Arena, Valeria Delli Carri, Tiziana Rollo, Pier Luigi Lopalco and Domenico Martinelli Tags: Research Source Type: research
Distribution of blood lead and cadmium levels in healthy children aged 0 to 18 years and analysis of related influencing factors in Henan, China: data findings from 2017 to 2022
ConclusionsPb and Cd exposure of children in this area is relatively low, but associated risk factors continue to exist in vulnerable populations. This study is the first big data analysis of Pb and Cd in children in Henan, China, and provides baseline information for future research. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 7, 2024 Category: Pediatrics Source Type: research
Healthcare migration in Italian paediatric haematology-oncology centres belonging to AIEOP
ConclusionsThere is still a certain amount of domestic migration, the causes of which can be easily identified: migration motivated by a search for high specialization, migration due to lack of local facilities, or regions in which no AIEOP centres are present, which makes migration obligatory.Better coordination between AIEOP centres could help to reduce so-called avoidable migration, but technical and political choices will have to be considered, with the active participation of sector technicians. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 7, 2024 Category: Pediatrics Source Type: research
Respiratory syncytial virus-associated hospitalizations among children: an Italian retrospective observational study
ConclusionsOur study contributes to outlining the baseline profile of RSV-associated hospitalizations among Italian children by providing epidemiological/clinical/economic estimates. While awaiting new recommendations on immunization, healthcare-workers should persist in implementing public health measures and appropriate case management to control RSV seasonal epidemics. Strengthened laboratory RSV surveillance is needed to inform the implementation of the new immunization strategies. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 7, 2024 Category: Pediatrics Source Type: research
Pediatric asthma and altitude: a complex interplay between different environmental factors
AbstractAsthma is one of the most common non-communicable diseases, and its prevalence and morbidity are influenced by a wide array of factors that are only partially understood. In addition to individual predisposition linked to genetic background and early life infections, environmental factors are crucial in determining the impact of asthma both on an individual patient and on a population level.Several studies have examined the role of the environment where asthmatic subjects live in the pathogenesis of asthma. This review aims to investigate the differences in the prevalence and characteristics of asthma between the p...
Source: Italian Journal of Pediatrics - March 6, 2024 Category: Pediatrics Source Type: research
Pediatric asthma and altitude: a complex interplay between different environmental factors
Asthma is one of the most common non-communicable diseases, and its prevalence and morbidity are influenced by a wide array of factors that are only partially understood. In addition to individual predispositi... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 6, 2024 Category: Pediatrics Authors: Laura Bisoffi, Giovanni Sassudelli, Fabio Agostinis, Annalisa Cogo, Renato Cutrera, Irene Dalpiaz, Maria Elisa Di Cicco, Battista Guidi, Stefania La Grutta, Andrea Miceli, Francesca Mori, Giorgio Piacentini, Diego Peroni, Deborah Snjiders, Mattia Giovanni Tags: Review Source Type: research
Neonatal persistent pulmonary hypertension related to a novel TBX4 mutation: case report and review of the literature
AbstractTBX4 gene, located on human chromosome 17q23.2, encodes for T-Box Transcription Factor 4, a transcription factor that belongs to the T-box gene family and it is involved in the regulation of some embryonic developmental processes, with a significant impact on respiratory and skeletal illnesses. Herein, we present the case of a female neonate with persistent pulmonary hypertension (PH) who underwent extracorporeal membrane oxygenation (ECMO) on the first day of life and then resulted to have a novel variant of theTBX4 gene identified by Next-Generation Sequencing. We review the available literature about the associa...
Source: Italian Journal of Pediatrics - March 5, 2024 Category: Pediatrics Source Type: research
Neonatal persistent pulmonary hypertension related to a novel TBX4 mutation: case report and review of the literature
TBX4 gene, located on human chromosome 17q23.2, encodes for T-Box Transcription Factor 4, a transcription factor that belongs to the T-box gene family and it is involved in the regulation of some embryonic develo... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 5, 2024 Category: Pediatrics Authors: Chiara Maddaloni, Sara Ronci, Domenico Umberto De Rose, Iliana Bersani, Francesca Campi, Matteo Di Nardo, Francesca Stoppa, Rachele Adorisio, Antonio Amodeo, Alessandra Toscano, Maria Cristina Digilio, Antonio Novelli, Giovanni Chello, Annabella Braguglia Tags: Review Source Type: research
