Lipid clinical trials with special reference to Indian population
Indian Heart J. 2024 Feb 20:S0019-4832(24)00021-X. doi: 10.1016/j.ihj.2024.02.003. Online ahead of print.ABSTRACTIndians have a pattern of atherogenic dyslipidaemia characterised by not so high LDL-C but elevated small, dense LDL-C, elevated triglyceride levels and low HDL-C levels. In addition, different lipid-lowering drugs exhibit pharmacokinetic variability in Indians, which may have implications on the optimum doses required to achieve the desired LDL-C levels. Currently the management of dyslipidaemia in Indians are based on the landmark trials, which largely included western population. This review focusses on major...
Source: Indian Heart J - February 22, 2024 Category: Cardiology Authors: Aseem Basha Sivasubramanian Ramakrishnan Source Type: research
Unveiling HPV's Hidden Link: Cardiovascular Diseases and the Viral Intrigue
Indian Heart J. 2024 Feb 20:S0019-4832(24)00019-1. doi: 10.1016/j.ihj.2024.02.001. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) remain a major global health challenge, with an escalating impact on mortality despite advancements in managing conventional risk factors. This review investigates the intricate relationship between human papillomavirus (HPV) and CVD, shedding light on a novel aspect of cardiovascular health. Despite significant progress in understanding and managing traditional CVD risk factors, a substantial proportion of CVD cases lack these conventional markers. Recent research has unveiled HPV,...
Source: Indian Heart J - February 22, 2024 Category: Cardiology Authors: Preyangsee Dutta Dwaipayan Saha Mrudul Earle Chandra Prakash Prasad Mayank Singh Mrinalini Darswal Vipul Aggarwal Nitish Naik Rakesh Yadav Abhishek Shankar Abhijit Chakraborty Source Type: research
Lipid clinical trials with special reference to Indian population
Indian Heart J. 2024 Feb 20:S0019-4832(24)00021-X. doi: 10.1016/j.ihj.2024.02.003. Online ahead of print.ABSTRACTIndians have a pattern of atherogenic dyslipidaemia characterised by not so high LDL-C but elevated small, dense LDL-C, elevated triglyceride levels and low HDL-C levels. In addition, different lipid-lowering drugs exhibit pharmacokinetic variability in Indians, which may have implications on the optimum doses required to achieve the desired LDL-C levels. Currently the management of dyslipidaemia in Indians are based on the landmark trials, which largely included western population. This review focusses on major...
Source: Indian Heart J - February 22, 2024 Category: Cardiology Authors: Aseem Basha Sivasubramanian Ramakrishnan Source Type: research
Unveiling HPV's Hidden Link: Cardiovascular Diseases and the Viral Intrigue
Indian Heart J. 2024 Feb 20:S0019-4832(24)00019-1. doi: 10.1016/j.ihj.2024.02.001. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) remain a major global health challenge, with an escalating impact on mortality despite advancements in managing conventional risk factors. This review investigates the intricate relationship between human papillomavirus (HPV) and CVD, shedding light on a novel aspect of cardiovascular health. Despite significant progress in understanding and managing traditional CVD risk factors, a substantial proportion of CVD cases lack these conventional markers. Recent research has unveiled HPV,...
Source: Indian Heart J - February 22, 2024 Category: Cardiology Authors: Preyangsee Dutta Dwaipayan Saha Mrudul Earle Chandra Prakash Prasad Mayank Singh Mrinalini Darswal Vipul Aggarwal Nitish Naik Rakesh Yadav Abhishek Shankar Abhijit Chakraborty Source Type: research
Lipid clinical trials with special reference to Indian population
Indian Heart J. 2024 Feb 20:S0019-4832(24)00021-X. doi: 10.1016/j.ihj.2024.02.003. Online ahead of print.ABSTRACTIndians have a pattern of atherogenic dyslipidaemia characterised by not so high LDL-C but elevated small, dense LDL-C, elevated triglyceride levels and low HDL-C levels. In addition, different lipid-lowering drugs exhibit pharmacokinetic variability in Indians, which may have implications on the optimum doses required to achieve the desired LDL-C levels. Currently the management of dyslipidaemia in Indians are based on the landmark trials, which largely included western population. This review focusses on major...
Source: Indian Heart J - February 22, 2024 Category: Cardiology Authors: Aseem Basha Sivasubramanian Ramakrishnan Source Type: research
Unveiling HPV's Hidden Link: Cardiovascular Diseases and the Viral Intrigue
Indian Heart J. 2024 Feb 20:S0019-4832(24)00019-1. doi: 10.1016/j.ihj.2024.02.001. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) remain a major global health challenge, with an escalating impact on mortality despite advancements in managing conventional risk factors. This review investigates the intricate relationship between human papillomavirus (HPV) and CVD, shedding light on a novel aspect of cardiovascular health. Despite significant progress in understanding and managing traditional CVD risk factors, a substantial proportion of CVD cases lack these conventional markers. Recent research has unveiled HPV,...
Source: Indian Heart J - February 22, 2024 Category: Cardiology Authors: Preyangsee Dutta Dwaipayan Saha Mrudul Earle Chandra Prakash Prasad Mayank Singh Mrinalini Darswal Vipul Aggarwal Nitish Naik Rakesh Yadav Abhishek Shankar Abhijit Chakraborty Source Type: research
Trends in epidemiology of dyslipidemias in India
Indian Heart J. 2024 Feb 12:S0019-4832(23)00457-1. doi: 10.1016/j.ihj.2023.11.266. Online ahead of print.ABSTRACTDyslipidemias are the most important coronary artery disease (CAD) risk factor. High total cholesterol and its principal subtypes: low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (NHDL) cholesterol are the most important. Epidemiological and Mendelian randomization studies have confirmed role of raised triglycerides and lipoprotein(a). INTERHEART study reported a significant association of raised ApoB/ApoA1, total-, LDL-, and NHDL-cholesterol in South Asians. Prospective Urban Rural Ep...
Source: Indian Heart J - February 15, 2024 Category: Cardiology Authors: Sonali Sharma Kiran Gaur Rajeev Gupta Source Type: research
Managing dyslipidaemia in young adults
Indian Heart J. 2024 Feb 12:S0019-4832(23)00456-X. doi: 10.1016/j.ihj.2023.11.265. Online ahead of print.ABSTRACTIndians have early onset atherosclerotic cardiovascular disease and acquire the risk factors at a younger age, and hence we need to aggressively address the management of dyslipidemia in the young. Cholesterol levels early in life will influence the development of atherosclerosis. Young atherosclerotic cardiovascular disease (ASCVD) patients (18-40 yrs) should receive lipid-lowering drugs to reduce LDL-C<55 mg. Due to the asymptomatic nature of dyslipidemia, early screening will enable the implementation of m...
Source: Indian Heart J - February 15, 2024 Category: Cardiology Authors: Jamshed J Dalal Tabassum Khan Source Type: research
Trends in epidemiology of dyslipidemias in India
Indian Heart J. 2024 Feb 12:S0019-4832(23)00457-1. doi: 10.1016/j.ihj.2023.11.266. Online ahead of print.ABSTRACTDyslipidemias are the most important coronary artery disease (CAD) risk factor. High total cholesterol and its principal subtypes: low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (NHDL) cholesterol are the most important. Epidemiological and Mendelian randomization studies have confirmed role of raised triglycerides and lipoprotein(a). INTERHEART study reported a significant association of raised ApoB/ApoA1, total-, LDL-, and NHDL-cholesterol in South Asians. Prospective Urban Rural Ep...
Source: Indian Heart J - February 15, 2024 Category: Cardiology Authors: Sonali Sharma Kiran Gaur Rajeev Gupta Source Type: research
Managing dyslipidaemia in young adults
Indian Heart J. 2024 Feb 12:S0019-4832(23)00456-X. doi: 10.1016/j.ihj.2023.11.265. Online ahead of print.ABSTRACTIndians have early onset atherosclerotic cardiovascular disease and acquire the risk factors at a younger age, and hence we need to aggressively address the management of dyslipidemia in the young. Cholesterol levels early in life will influence the development of atherosclerosis. Young atherosclerotic cardiovascular disease (ASCVD) patients (18-40 yrs) should receive lipid-lowering drugs to reduce LDL-C<55 mg. Due to the asymptomatic nature of dyslipidemia, early screening will enable the implementation of m...
Source: Indian Heart J - February 15, 2024 Category: Cardiology Authors: Jamshed J Dalal Tabassum Khan Source Type: research
Trends in epidemiology of dyslipidemias in India
Indian Heart J. 2024 Feb 12:S0019-4832(23)00457-1. doi: 10.1016/j.ihj.2023.11.266. Online ahead of print.ABSTRACTDyslipidemias are the most important coronary artery disease (CAD) risk factor. High total cholesterol and its principal subtypes: low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (NHDL) cholesterol are the most important. Epidemiological and Mendelian randomization studies have confirmed role of raised triglycerides and lipoprotein(a). INTERHEART study reported a significant association of raised ApoB/ApoA1, total-, LDL-, and NHDL-cholesterol in South Asians. Prospective Urban Rural Ep...
Source: Indian Heart J - February 15, 2024 Category: Cardiology Authors: Sonali Sharma Kiran Gaur Rajeev Gupta Source Type: research
Managing dyslipidaemia in young adults
Indian Heart J. 2024 Feb 12:S0019-4832(23)00456-X. doi: 10.1016/j.ihj.2023.11.265. Online ahead of print.ABSTRACTIndians have early onset atherosclerotic cardiovascular disease and acquire the risk factors at a younger age, and hence we need to aggressively address the management of dyslipidemia in the young. Cholesterol levels early in life will influence the development of atherosclerosis. Young atherosclerotic cardiovascular disease (ASCVD) patients (18-40 yrs) should receive lipid-lowering drugs to reduce LDL-C<55 mg. Due to the asymptomatic nature of dyslipidemia, early screening will enable the implementation of m...
Source: Indian Heart J - February 15, 2024 Category: Cardiology Authors: Jamshed J Dalal Tabassum Khan Source Type: research
Trends in epidemiology of dyslipidemias in India
Indian Heart J. 2024 Feb 12:S0019-4832(23)00457-1. doi: 10.1016/j.ihj.2023.11.266. Online ahead of print.ABSTRACTDyslipidemias are the most important coronary artery disease (CAD) risk factor. High total cholesterol and its principal subtypes: low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (NHDL) cholesterol are the most important. Epidemiological and Mendelian randomization studies have confirmed role of raised triglycerides and lipoprotein(a). INTERHEART study reported a significant association of raised ApoB/ApoA1, total-, LDL-, and NHDL-cholesterol in South Asians. Prospective Urban Rural Ep...
Source: Indian Heart J - February 15, 2024 Category: Cardiology Authors: Sonali Sharma Kiran Gaur Rajeev Gupta Source Type: research
Managing dyslipidaemia in young adults
Indian Heart J. 2024 Feb 12:S0019-4832(23)00456-X. doi: 10.1016/j.ihj.2023.11.265. Online ahead of print.ABSTRACTIndians have early onset atherosclerotic cardiovascular disease and acquire the risk factors at a younger age, and hence we need to aggressively address the management of dyslipidemia in the young. Cholesterol levels early in life will influence the development of atherosclerosis. Young atherosclerotic cardiovascular disease (ASCVD) patients (18-40 yrs) should receive lipid-lowering drugs to reduce LDL-C<55 mg. Due to the asymptomatic nature of dyslipidemia, early screening will enable the implementation of m...
Source: Indian Heart J - February 15, 2024 Category: Cardiology Authors: Jamshed J Dalal Tabassum Khan Source Type: research
Trends in epidemiology of dyslipidemias in India
Indian Heart J. 2024 Feb 12:S0019-4832(23)00457-1. doi: 10.1016/j.ihj.2023.11.266. Online ahead of print.ABSTRACTDyslipidemias are the most important coronary artery disease (CAD) risk factor. High total cholesterol and its principal subtypes: low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (NHDL) cholesterol are the most important. Epidemiological and Mendelian randomization studies have confirmed role of raised triglycerides and lipoprotein(a). INTERHEART study reported a significant association of raised ApoB/ApoA1, total-, LDL-, and NHDL-cholesterol in South Asians. Prospective Urban Rural Ep...
Source: Indian Heart J - February 15, 2024 Category: Cardiology Authors: Sonali Sharma Kiran Gaur Rajeev Gupta Source Type: research
