Non adherence to lipid-lowering therapy and strategies to improve adherence
Indian Heart J. 2024 Jan 10:S0019-4832(24)00006-3. doi: 10.1016/j.ihj.2024.01.006. Online ahead of print.ABSTRACTLipid lowering therapies is well-established to prevent cardiovascular events in adults with dyslipidemia and multiple risk factors. However, global clinical usage of LLT,particularly statins remains suboptimal, with adherence low rates for primary prevention and secondary prevention. Low adherence is influenced by concerns about side effects, misconceptions about benefits. Patients often discontinue statins due to perceived side effects, despite clinical trials showing no increase in symptoms compared to placeb...
Source: Indian Heart J - January 11, 2024 Category: Cardiology Authors: Ashwani Mehta Source Type: research
Managing dyslipidemia in solid organ transplant patients
Indian Heart J. 2024 Jan 8:S0019-4832(24)00004-X. doi: 10.1016/j.ihj.2024.01.004. Online ahead of print.ABSTRACTSolid organ transplant recipients face an increased risk of dyslipidemia, which contributes to cardiovascular complications. Commonly used drugs such as ciclosporin and tacrolimus can aggravate and cause dyslipidemia. Immunosuppressive drugs particularly ciclosporin and tacrolimus are also known to worsendyslipidemia in transplant recipients. Mammalian target of rapamycin (mTOR) inhibitors like sirolimus and everolimus also alter lipid metabolism. Lifestyle and dietary modifications should be encouraged. Careful ...
Source: Indian Heart J - January 10, 2024 Category: Cardiology Authors: Ashwani Mehta Source Type: research
The 'qRBBB myocardial infarction': Unwrapping an old enigma
Indian Heart J. 2024 Jan 8:S0019-4832(24)00005-1. doi: 10.1016/j.ihj.2024.01.005. Online ahead of print.ABSTRACTThis single-center, prospective, observational study was conducted at a tertiary-care center over a span of two years. Patients presenting with acute Anterior-Wall STEMI were included as a study population. The subgroups included qRBBB pattern on ECG and non-qRBBB group. Among 1128 patients included in the study, 100 (11.28 %) patients presented with qRBBB pattern. Increased risk of cardiogenic shock, increased hospital-stay, a higher Killip class on presentation, high incidence of recanalized IRA, remarkably dep...
Source: Indian Heart J - January 10, 2024 Category: Cardiology Authors: Charan P Lanjewar Bhavik S Shah Girish R Sabnis Achal Sharma Dhiraj Kumar Source Type: research
Role of PCSK9 inhibitors in the management of dyslipidaemia
Indian Heart J. 2024 Jan 7:S0019-4832(23)00480-7. doi: 10.1016/j.ihj.2023.12.011. Online ahead of print.ABSTRACTProprotein convertase subtilisin kexin9 (PCSK9) inhibitors are novel agents that lower LDL cholesterol and reduce cardio-vascular event rate. Being expensive, these agents are reserved for those with high risk or very high risk of CV events and with suboptimal response to statins and ezetimibe, with or without bempedoic acid or those intolerant to statins.PMID:38195006 | DOI:10.1016/j.ihj.2023.12.011 (Source: Indian Heart J)
Source: Indian Heart J - January 9, 2024 Category: Cardiology Authors: Tiny Nair Source Type: research
Strain imaging as an early predictor in acute myocardial infarction - An augmented cross-sectional study
CONCLUSIONS: GLS by STE has good correlation with LVEF, WMSI and NT pro-BNP and it is an independent predictor of mortality and heart failure among patients with AMI.PMID:38185327 | DOI:10.1016/j.ihj.2024.01.001 (Source: Indian Heart J)
Source: Indian Heart J - January 7, 2024 Category: Cardiology Authors: Dhananjay Kumar Manish Saha Santanu Guha Tirthankar Roy Rohit Kumar Abhirup K Sinha Source Type: research
18F- FDG PET/CT in reclassifying the probable diagnosis of IE - A review
Indian Heart J. 2024 Jan 5:S0019-4832(24)00003-8. doi: 10.1016/j.ihj.2024.01.003. Online ahead of print.ABSTRACTIn the diagnosis of infective endocarditis (IE), Modified Duke's criteria, coupled with clinical suspicion, serve as the guiding framework. For cases involving prosthetic valve endocarditis and infections affecting implantable devices, the use of metabolic imaging with 18 F-FDG PET/CT scans has gained prominence, as per the recommendations of the European Society of Cardiology guidelines. This imaging modality enhances sensitivity and specificity by identifying infective foci within the heart and extracardiac loc...
Source: Indian Heart J - January 7, 2024 Category: Cardiology Authors: I Sathyamurthy Indirani Elangovan Source Type: research
Strain imaging as an early predictor in acute myocardial infarction - An augmented cross-sectional study
CONCLUSIONS: GLS by STE has good correlation with LVEF, WMSI and NT pro-BNP and it is an independent predictor of mortality and heart failure among patients with AMI.PMID:38185327 | DOI:10.1016/j.ihj.2024.01.001 (Source: Indian Heart J)
Source: Indian Heart J - January 7, 2024 Category: Cardiology Authors: Dhananjay Kumar Manish Saha Santanu Guha Tirthankar Roy Rohit Kumar Abhirup K Sinha Source Type: research
18F- FDG PET/CT in reclassifying the probable diagnosis of IE - A review
Indian Heart J. 2024 Jan 5:S0019-4832(24)00003-8. doi: 10.1016/j.ihj.2024.01.003. Online ahead of print.ABSTRACTIn the diagnosis of infective endocarditis (IE), Modified Duke's criteria, coupled with clinical suspicion, serve as the guiding framework. For cases involving prosthetic valve endocarditis and infections affecting implantable devices, the use of metabolic imaging with 18 F-FDG PET/CT scans has gained prominence, as per the recommendations of the European Society of Cardiology guidelines. This imaging modality enhances sensitivity and specificity by identifying infective foci within the heart and extracardiac loc...
Source: Indian Heart J - January 7, 2024 Category: Cardiology Authors: I Sathyamurthy Indirani Elangovan Source Type: research
Comparison of Indian clinical practice guidelines for the management of hypertension with the World Health Organization, International Society of Hypertension, American, and European guidelines
Indian Heart J. 2024 Jan 1:S0019-4832(23)00478-9. doi: 10.1016/j.ihj.2023.12.009. Online ahead of print.ABSTRACTHypertension is the leading risk factor for preventable cardiovascular diseases and all-cause mortality globally, with majority of the hypertension-attributed deaths occurring in low- and middle-income countries like India. Several international and national clinical practice guidelines (CPGs) provide evidence-informed recommendations to achieve optimal control. CPGs produced by the World Health Organization, International Society for Hypertension, American (AHA/ACC-2017), and European (ESC/ESH-2018) are "major" ...
Source: Indian Heart J - January 3, 2024 Category: Cardiology Authors: Gautam Satheesh Rupasvi Dhurjati Jayagopal Pathiyil Balagopalan Padinhare P Mohanan Abdul Salam Source Type: research
Comparison of Indian clinical practice guidelines for the management of hypertension with the World Health Organization, International Society of Hypertension, American, and European guidelines
Indian Heart J. 2024 Jan 1:S0019-4832(23)00478-9. doi: 10.1016/j.ihj.2023.12.009. Online ahead of print.ABSTRACTHypertension is the leading risk factor for preventable cardiovascular diseases and all-cause mortality globally, with majority of the hypertension-attributed deaths occurring in low- and middle-income countries like India. Several international and national clinical practice guidelines (CPGs) provide evidence-informed recommendations to achieve optimal control. CPGs produced by the World Health Organization, International Society for Hypertension, American (AHA/ACC-2017), and European (ESC/ESH-2018) are "major" ...
Source: Indian Heart J - January 3, 2024 Category: Cardiology Authors: Gautam Satheesh Rupasvi Dhurjati Jayagopal Pathiyil Balagopalan Padinhare P Mohanan Abdul Salam Source Type: research
Comparison of Indian clinical practice guidelines for the management of hypertension with the World Health Organization, International Society of Hypertension, American, and European guidelines
Indian Heart J. 2024 Jan 1:S0019-4832(23)00478-9. doi: 10.1016/j.ihj.2023.12.009. Online ahead of print.ABSTRACTHypertension is the leading risk factor for preventable cardiovascular diseases and all-cause mortality globally, with majority of the hypertension-attributed deaths occurring in low- and middle-income countries like India. Several international and national clinical practice guidelines (CPGs) provide evidence-informed recommendations to achieve optimal control. CPGs produced by the World Health Organization, International Society for Hypertension, American (AHA/ACC-2017), and European (ESC/ESH-2018) are "major" ...
Source: Indian Heart J - January 3, 2024 Category: Cardiology Authors: Gautam Satheesh Rupasvi Dhurjati Jayagopal Pathiyil Balagopalan Padinhare P Mohanan Abdul Salam Source Type: research
Comparison of Indian clinical practice guidelines for the management of hypertension with the World Health Organization, International Society of Hypertension, American, and European guidelines
Indian Heart J. 2024 Jan 1:S0019-4832(23)00478-9. doi: 10.1016/j.ihj.2023.12.009. Online ahead of print.ABSTRACTHypertension is the leading risk factor for preventable cardiovascular diseases and all-cause mortality globally, with majority of the hypertension-attributed deaths occurring in low- and middle-income countries like India. Several international and national clinical practice guidelines (CPGs) provide evidence-informed recommendations to achieve optimal control. CPGs produced by the World Health Organization, International Society for Hypertension, American (AHA/ACC-2017), and European (ESC/ESH-2018) are "major" ...
Source: Indian Heart J - January 3, 2024 Category: Cardiology Authors: Gautam Satheesh Rupasvi Dhurjati Jayagopal Pathiyil Balagopalan Padinhare P Mohanan Abdul Salam Source Type: research
Lipoprotein a - Lp(a)
Indian Heart J. 2023 Dec 29:S0019-4832(23)00479-0. doi: 10.1016/j.ihj.2023.12.010. Online ahead of print.ABSTRACTLp(a) is a genetically determined, heritable, independent and causal risk factor for ASCVD. About 1 in 5 people worldwide have elevated Lp(a) (>50 mg/dL or >125 nmol/L) whereas in Indians it is 25 %. Epidemiological, genome-wide association and mendelian randomization studies have demonstrated an association between elevated Lp(a) levels and increased incidence of. myocardial Infarction, aortic valve stenosis, ischemic stroke, heart failure, CV and all-cause mortality. The increased Lp(a)-mediated CV risk ...
Source: Indian Heart J - December 31, 2023 Category: Cardiology Authors: Tapan Ghose Source Type: research
Dyslipidaemia in endocrine disorders
Indian Heart J. 2023 Dec 29:S0019-4832(23)00481-9. doi: 10.1016/j.ihj.2023.12.012. Online ahead of print.ABSTRACTLipid disorders are common in several endocrine conditions. Diabetes mellitus, hypothyroidism and Cushing's syndrome are the common endocrine disorders with dyslipidemia. Dyslipidemia has a significant impact on endocrine and metabolic health and the risk of atherosclerotic cardiovascular disease. In most cases of dyslipidemia, the suspicion of endocrine diseases must be based on clinical symptoms and signs. Optimal management of the dyslipidemia requires treatment of the underlying endocrine condition. Lipid lo...
Source: Indian Heart J - December 31, 2023 Category: Cardiology Authors: Kalyani Sridharan Sanjay Kalra Source Type: research
Lipoprotein a - Lp(a)
Indian Heart J. 2023 Dec 29:S0019-4832(23)00479-0. doi: 10.1016/j.ihj.2023.12.010. Online ahead of print.ABSTRACTLp(a) is a genetically determined, heritable, independent and causal risk factor for ASCVD. About 1 in 5 people worldwide have elevated Lp(a) (>50 mg/dL or >125 nmol/L) whereas in Indians it is 25 %. Epidemiological, genome-wide association and mendelian randomization studies have demonstrated an association between elevated Lp(a) levels and increased incidence of. myocardial Infarction, aortic valve stenosis, ischemic stroke, heart failure, CV and all-cause mortality. The increased Lp(a)-mediated CV risk ...
Source: Indian Heart J - December 31, 2023 Category: Cardiology Authors: Tapan Ghose Source Type: research
