Impedance-Readout Integrated Circuits for Electrical Impedance Spectroscopy: Methodological Review
This article reviews the principles, advantages, and disadvantages of techniques employed in state-of-the-art impedance-readout ICs, aiming to achieve high energy efficiency, wide frequency range, high accuracy, wide dynamic range, low noise, high throughput, and/or high input impedance. The thorough review of these advancements will provide valuable insights into the future development of impedance-readout ICs and systems for IoT and biomedical applications. (Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - September 26, 2023 Category: Biomedical Engineering Source Type: research

An MRI Compatible Data Acquisition Device for Rat Brain Recording Inside 16.4T Magnet
This article presents a low-noise, frequency-shaping based neural recorder chip that is insensitive to radio frequency (RF) pulses and gradient echo artifacts under strong magnetic environment. To support simultaneous recording of local field potentials (LFPs), extracellular spikes, and fMRI data, a magnetic resonance imaging (MRI) compatible data acquisition (DAQ) device based on the designed recorder chip is developed with multiple circuit optimization techniques. Bench-top measurement shows that the designed DAQ device has 4.5 $\mu$V input-referred noise integrated from 300 Hz to 3000 Hz, which is not greatly affected b...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 25, 2023 Category: Biomedical Engineering Source Type: research

A 4-Channel Neural Stimulation IC Design With Charge Balancing and Multiple Current Output Modes
This article proposes a neural stimulation integrated circuit design with multiple current output modes. In the cathodic stimulation phase and anodic stimulation phase, each output current waveform can be independently selected to either exponential waveform or square wave, so the stimulator holds four stimulation modes. To minimize the headroom voltage of the output stage and enhance the power efficiency of the proposed stimulator, we introduce the exponentially decaying current which is realized by the exponential current generation circuit in this work. It can enhance the longer duration of the stimulation pulse as well...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 22, 2023 Category: Biomedical Engineering Source Type: research

NADOL: Neuromorphic Architecture for Spike-Driven Online Learning by Dendrites
This study's applicability extends across diverse domains, including the Internet of Things, robotic control, and brain-machine interfaces. Moreover, it signifies a pivotal step in bridging the gap between artificial intelligence and neuroscience through the introduction of an innovative neuromorphic paradigm. (Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - September 19, 2023 Category: Biomedical Engineering Source Type: research

A Highly Integrated Lab-on-a-CMOS Platform for Real-Time Monitoring of E. Coli Growth Kinetics
Existing miniaturized and cost-effective solutions for bacterial growth monitoring usually require offline incubators with constant temperature to culture the bio-samples prior to measurement. Such a separated sample preparation and detection scheme requires extensive human intervention, risks contamination, and suffers from poor temporal resolution. To achieve integrated sample preparation and real-time bacterial growth monitoring, this article presents a lab-on-a-CMOS platform incorporates an optical sensor array, temperature sensor array, micro-heaters, and readout circuits. Escherichia coli's (E. coli) optimum growth t...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 14, 2023 Category: Biomedical Engineering Source Type: research

An Adaptive Filter Based Motion Artifact Cancellation Technique Using Multi-Wavelength PPG for Accurate HR Estimation
This article presents a motion artifact (MA) cancellation technique for accurate photoplethysmography (PPG)-based heart rate (HR) estimation. The MA is canceled using two PPG signals, measured with closely placed red and green LEDs. The proposed technique utilizes the characteristics of the two PPG signals: the high correlation in MA and their different AC/DC ratios. These characteristics allow the MA to be canceled by an adaptive filter while preserving the AC components. In addition, the use of the sign-sign least mean square (SS-LMS) algorithm for the adaptive filter minimizes the hardware resource requirements. To vali...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 14, 2023 Category: Biomedical Engineering Source Type: research

Rotation-Tolerant Wireless Power Transmission Scheme with Smart Positioning for Cognitive Research on Moving Animals
This article presents a novel wireless power transmission scheme designed for moving loads. Specifically focused on compensating for the tilt misalignment of the receiver. By utilizing phase-shifted excitation signals from an array of transmitters, the proposed scheme effectively mitigates the impact of misalignment, locally. The application of this scheme holds particular relevance for studying the behavior of moving animals in cognitive research. The system incorporates a cage with two transmitter arrays positioned on the top and bottom sides. To smart determining the receiver's position, the proposed structure utilizes ...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 13, 2023 Category: Biomedical Engineering Source Type: research

Detection Capability Enhanced Biosensor Antenna for Portable Electromagnetic Stroke Diagnostic Systems
This article presents a detect capability enhanced biosensor antenna with a planar and compact configuration for portable EM stroke detection systems, overcoming the problem of limited detection capability in existing designs for this application. The proposed antenna is developed based on multiple dipoles, exhibiting multi-mode resonances and complementary interaction. In the frequency domain, the simulated and measured results with the presence of head phantoms show that this compact planar antenna achieves improved performance in both impedance bandwidth and near-field radiation inside the head tissues, which all contri...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 11, 2023 Category: Biomedical Engineering Source Type: research

Novel Wearable HD-EMG Sensor With Shift-Robust Gesture Recognition Using Deep Learning
In this work, we present a hardware-software solution to improve the robustness of hand gesture recognition to confounding factors in myoelectric control. The solution includes a novel, full-circumference, flexible, 64-channel high-density electromyography (HD-EMG) sensor called EMaGer. The stretchable, wearable sensor adapts to different forearm sizes while maintaining uniform electrode density around the limb. Leveraging this uniformity, we propose novel array barrel-shifting data augmentation (ABSDA) approach used with a convolutional neural network (CNN), and an anti-aliased CNN (AA-CNN), that provides shift invariance...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 11, 2023 Category: Biomedical Engineering Source Type: research

A 107.6 dB-DR Three-Step Incremental ADC for Motion-Tolerate Biopotential Signals Recording
This article describes a power-efficient, high dynamic range (DR) incremental ADC (IADC) for wearable biopotential signals recording, where DC and low-frequency disturbances such as electrode offset, 50/60 Hz interference and motion artifact must be tolerated. To achieve a wide DR, the IADC performs a three-step conversion by combining zoom-SAR and extended counting (EC) on top of a second-order incremental delta-sigma modulator (ΔΣM). The hybrid architecture notably reduces the oversampling ratio (OSR) with respect to conventional incremental ΔΣMs, while using the EC further improves the Signal-to-Noise-and-Distortion...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 8, 2023 Category: Biomedical Engineering Source Type: research

Reservoir Computing With Dynamic Reservoir using Cascaded DNA Memristors
This article proposes molecular and DNA memristors where the state is defined by a single output variable. In past molecular and DNA memristors, the state of the memristor was defined based on two output variables. These memristors cannot be cascaded because their input and output sizes are different. We introduce a different definition of state for the molecular and DNA memristors. This change allows cascading of memristors. The proposed memristors are used to build reservoir computing (RC) models that can process temporal inputs. An RC system consists of two parts: reservoir and readout layer. The first part projects the...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 5, 2023 Category: Biomedical Engineering Source Type: research

A High CMRR Differential Difference Amplifier Employing Combined Input Pairs for Neural Signal Recordings
This article introduces a Combined .symmetrical and complementary Input Pairs (CIP) of a Differential Difference Amplifier (DDA), to boost the total Common-Mode Rejection Ratio (CMRR) for multi-channel neural signal recording. The proposed CIP-DDA employs three input pairs (transconductors). The dc-coupled input neural signal connection, via the gate terminal of the first transconductor, yields a high input impedance. The high-pass corner frequency and dc quiescent operation point are stabilized by the second transconductor. The calibration path of differential-mode gain and Common-Mode Feedback (CMFB) is provided by the p...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 4, 2023 Category: Biomedical Engineering Source Type: research

A 97-Channel Read-Out ASIC for an Electrophysiological Mapping Catheter With an Optical Link
Electrophysiological (EP) mapping catheters are medical equipment, which are widely used to diagnose and treat atrial fibrillation. The electrophysiology signals are sensed by the catheter's electrodes, for which a large electrode count becomes more and more essential because of the demand for a higher local resolution. A drawback of the large electrode count is the effort to pass through and to integrate the wires inside the catheter shaft. To overcome with this issue, this article describes the realization of an EP ASIC, which is placed close to the 97 electrodes and to perform an in-tip digitization. Thanks to an integr...
Source: IEEE Transactions on Biomedical Circuits and Systems - September 4, 2023 Category: Biomedical Engineering Source Type: research

GaN-Based 4-MHz Full-Bridge Electrosurgical Generator Using Zero-Voltage Switching Over Wide Load Impedance Range
In this article, a 4-MHz full-bridge inverter system for an electrosurgical generator (ESG) is presented with zero-voltage switching (ZVS) turn-on over a wide load impedance range based on wideband gap material gallium nitride (GaN) technology. The proposed resonant circuit is used for impedance matching and limits the current when the load is short state while performing ZVS over a wide load impedance range. It also ensures high power performance at high frequencies for electric surgery. The implementation methods of the GaN switch at 4 MHz with high output performance are guided by the low inductance from the gate-driver...
Source: IEEE Transactions on Biomedical Circuits and Systems - August 31, 2023 Category: Biomedical Engineering Source Type: research

Flexi-EIT: A Flexible and Reconfigurable Active Electrode Electrical Impedance Tomography System
Electrical Impedance Tomography (EIT) systems have shown great promise in many fields such as real-time wearable healthcare imaging, but their fixed number of electrodes and placement locations limit the system's flexibility and adaptability for further advancement. In this article, we propose a flexible and reconfigurable EIT system (Flexi-EIT) based on digital active electrode (DAE) architecture to address these limitations. By integrating a reconfigurable number of up to 32 replaceable DAEs into the flexible printed circuit (FPC) based wearable electrode belt, we can enable rapid, reliable, and easy placement while main...
Source: IEEE Transactions on Biomedical Circuits and Systems - August 22, 2023 Category: Biomedical Engineering Source Type: research