A Flexible Implant for Multi-Day Monitoring of Colon Segment Activity
Monitoring of colon activity is currently limited to tethered systems like anorectal manometry. These systems have significant drawbacks, but fundamentally limit the observation time of colon activity, reducing the likelihood of detecting specific clinical events. While significant technological advancement has been directed to mobile sensor capsules, this work describes the development and feasibility of a stationary sensor for describing the coordinated activity between neighboring segments of the colon. Unlike wireless capsules, this device remains in position and measures propagating pressure waves and impedances betwe...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 26, 2023 Category: Biomedical Engineering Source Type: research

Dense, 11 V-Tolerant, Balanced Stimulator IC with Digital Time-Domain Calibration for $< $100 nA Error
This article presents a multichannel neurostimulator implementing a novel charge balancing technique to achieve maximal integration. Safe neurostimulation demands accurate charge balancing of the stimulation waveforms to prevent charge build-up on the electrode-tissue interface. We propose digital time-domain calibration (DTDC), which adjusts the second phase of the biphasic stimulation pulses digitally, based on a one-time characterization of all stimulator channels with an on-chip ADC. Accurate control of the stimulation current amplitude is loosened in exchange for time-domain corrections, relieving circuit matching con...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 19, 2023 Category: Biomedical Engineering Source Type: research

Toward a Smart Sensing System to Monitor Small Animal's Physical State via Multi-Frequency Resonator Array
This article presents a highly scalable and rack-mountable wireless sensing system for long-term monitoring (i.e., sense and estimate) of small animal/s' physical state (SAPS), such as changes in location and posture within standard cages. The conventional tracking systems may lack one or more features such as scalability, cost efficiency, rack-mount ability, and light condition insensitivity to work 24/7 on a large scale. The proposed sensing mechanism relies on relative changes of multiple resonance frequencies due to the animal's presence over the sensor unit. The sensor unit can track SAPS changes based on changes in e...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 12, 2023 Category: Biomedical Engineering Source Type: research

Design and Evaluation of Wearable Multimodal RF Sensing System for Vascular Dementia Detection
This article presents a novel concept of low- complexity wearable sensing system for the detection of brain stroke and brain atrophy using RF sensors. This multimodal RF sensing system provides a first-of-its-kind RF sensing solution for the detection of cerebral blood density variations and blood clots at an initial stage of neurodegeneration. A customized microwave imaging algorithm is presented for the reconstruction of images in affected areas of the brain. Designs are validated using software simulations and hardware modeling. Fabricated sensors are experimentally validated and can effectively detect blood density var...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 2, 2023 Category: Biomedical Engineering Source Type: research

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Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

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Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

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(Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

UArch: A Super-Resolution Processor With Heterogeneous Triple-Core Architecture for Workloads of U-Net Networks
High-resolution medical images are of critical significance to improve disease diagnosis. Limited by the camera and power of medical devices, medical images often have very low resolution. For example, wireless capsule endoscopes, often used to diagnose diseases of the small bowel, can only capture low-resolution endoscopic images. The existing super-resolution (SR) networks perform exceptionally well in recovering high-resolution images, but they are computationally expensive and require high bandwidth, which can result in unacceptable latency and bandwidth requirements for embedded medical devices. In this paper, we prop...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

An Ultra-Miniaturized High Efficiency Implanted Spiral Antenna for Leadless Cardiac Pacemakers
This article presents an ultra-miniaturized implant antenna with a volume of 22.22 mm$^{3}$ in the Medical Implant Communication Service (MICS) frequency band 402-405 MHz to be integrated with a leadless cardiac pacemaker. The proposed antenna has a planar spiral geometry with a defective ground plane exhibiting a radiation efficiency of 3.3% in the lossy medium with more than 20 dB of improved forward transmission, while the coupling can be further enhanced by adjusting the thickness of the antenna insulation and the antenna size according to the application area. The implanted antenna demonstrates a measured bandw...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

Standalone RF Self-Interference Cancellation System for In-Vivo Simultaneous Transmit and Receive (STAR) MRI
Demonstrated is a standalone RF self-interference canceller for simultaneous transmit and receive (STAR) magnetic resonance imaging (MRI) at 1.5T. Standalone STAR cancels the leakage signal directly coupled between transmit and receive RF coils. A cancellation signal, introduced by tapping the input of a transmit coil with a power divider, is manipulated with voltage-controlled attenuators and phase shifters to match the leakage signal in amplitude, 180° out of phase, to exhibit high isolation between the transmitter and receiver. The cancellation signal is initially generated by a voltage-controlled oscillator (VCO...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

A 0.99-to-4.38 uJ/class Event-Driven Hybrid Neural Network Processor for Full-Spectrum Neural Signal Analyses
Versatile and energy-efficient neural signal processors are in high demand in brain-machine interfaces and closed-loop neuromodulation applications. In this paper, we propose an energy-efficient processor for neural signal analyses. The proposed processor utilizes three key techniques to efficiently improve versatility and energy efficiency. 1) Hybrid neural network design: The processor supports artificial neural network (ANN)- and spiking neural network (SNN)-based neuromorphic processing where ANN is used to support the processing of ExG signals and SNN is used for handling neural spike signals. 2) Event-driven processi...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

An On-/Off-Time Sensing-Based Load-Adaptive Mode Control of Triple Mode Buck Converter for Implantable Medical Devices
Wireless power transfer (WPT) technology applied to implantable medical devices (IMDs) significantly reduces the need for battery replacement surgery health conditions. This paper presents an on-/off-time sensing-based load-adaptive mode control of triple mode buck converter for implantable medical devices; the converter can adjust the control mode for low power consumption and achieve high power conversion efficiency (PCE) under a small active area. The three modes in the proposed system are the pulse width modulation (PWM), pulse frequency modulation (PFM), and ultra-low power (ULP) modes. The on-time sensor can b...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

A Time-Domain Readout Technique for Neural Interfaces Based on VCO-Timestamping
This article introduces the VCO-timestamping concept, including theoretical derivations and simulations, and presents measurements of a prototype fabricated in 0.18-μm CMOS technology. The measured input-referred noise in the 300 Hz–5 kHz band was 5.7 μVrms, and the prototype was able to detect pre-recorded extracellular action potentials. (Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

A Portable Non-Invasive Electromagnetic Lesion-Optimized Sensing Device for the Diagnosis of Skin Cancer (SkanMD)
The article presented herein proposes an alternative skin cancer screening method that delivers non-invasive diagnosis and monitoring of skin lesions by leveraging electromagnetic waves with radio frequency technology and circuits. The proposed handheld device, named SkanMD, comprises a sensitive electromagnetic sensor, customized radio frequency wave analyzer circuits, and machine learning algorithms. The device is used in clinical studies that are performed on a total of 46 individuals that are composed of 18 patients with pre-diagnosed skin cancer, 10 individuals with benign nevi, 7 patients with arbitrary diseases, and...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research

Development and Validation of a Wearable Device to Provide Rich Somatosensory Stimulation for Rehabilitation After Sensorimotor Impairment
This study describes the development and validation of a non-invasive wearable device meant to repeatedly and safely deliver somatosensory stimulations. The development was guided by a structured design control process to ensure the verifiability and validity of the design outcomes. Two sub-systems were designed: 1) a tactile display for touch and vibration sensations, and 2) a set of bands for sliding, pressure, and strain sensations. The device was designed with a versatile structure that allows for its application on different body parts. We designed a device-paired interactive computer program to enable structured sens...
Source: IEEE Transactions on Biomedical Circuits and Systems - June 1, 2023 Category: Biomedical Engineering Source Type: research