Adaptively Clock-Boosted Auto-Ranging Neural-Interface for Emerging Neuromodulation Applications
Responsive deep brain stimulation (DBS) requires recruiting deep brain structures without affecting the superficial neuronal population. Neurosurgeons widely use implanted electrodes, which are highly localized but invasive, to stimulate the deep brain. Temporally interfering stimulation (TIS) excites the deep brain non-invasively. This neuromodulation technique utilizes two high-frequency sinusoidal electric fields that do not recruit superficial neural structures but have a small frequency differential. The small differential causes a low-frequency interference envelope that stimulates deep regions and is steerable by ch...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

A Low-Power Single-Path Bio-Impedance Measurement System Using an Analog-to-Digital Converter for I/Q Demodulation
In this paper, a low power single-path bio-impedance (Bio-Z) measurement system for early detection of acute myocardial ischemia is presented. The fully integrated system consists of a current source, an amplifier, and an analog-to-digital converter (ADC). The system utilizes the in-phase and quadrature (I/Q) components to obtain the real and imaginary parts of the tissue impedance. To achieve this goal, the ADC has been used to separate the I/Q components in addition to digitizing the samples. This can lead to power and silicon area reduction. The proposed circuit exploits the benefits of capacitively-couple...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

A 13.56 MHz Wireless Power Transfer System With Fully Integrated PLL-Based Frequency-Regulated Reconfigurable Duty Control for Implantable Medical Devices
In this paper, a 13.56 MHz wireless power transfer system with transmitter (TX) and receiver (RX) chips is presented. Both TX and RX chips were designed with fully integrated reconfigurable single power stage to realize adaptive power delivery and output voltage regulation. The reconfigurable operation of TX and RX is synchronized and the reconfiguration frequency which could vary with coupling or loading condition is locked by the proposed phase-locked-loop-based on-time duty controller to mitigate the electromagnetic interference. In addition, calibrations for circuit delay and power switch size were implemented in the R...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

Analog Gated Recurrent Unit Neural Network for Detecting Chewing Events
We present a novel gated recurrent neural network to detect when a person is chewing on food. We implemented the neural network as a custom analog integrated circuit in a 0.18 $mu$m CMOS technology. The neural network was trained on 6.4 hours of data collected from a contact microphone that was mounted on volunteers' mastoid bones. When tested on 1.6 hours of previously-unseen data, the analog neural network identified chewing events at a 24-second time resolution. It achieved a recall of 91% and an F1-score of 94% while consuming $1.1,mu$W of power. A system for detecting whole eating episodes—...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

Memristor Neural Network Circuit Based on Operant Conditioning With Immediacy and Satiety
Most of the operant conditioning only consider the basic theory, but the influencing factors such as immediacy and satiety are ignored. In this paper, a memristor neural network circuit based on operant conditioning with immediacy and satiety is proposed. The designed circuit is mainly composed of voltage control modules, synapse modules and promotion-suppression modules. The various processes of operant conditioning theory are realized. The relationship between positive reward and negative punishment is implemented through promotion-suppression modules and synapse modules. The influence of immediacy on operant conditionin...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

A Review of Emerging Electromagnetic-Acoustic Sensing Techniques for Healthcare Monitoring
This article reviews various examples of EMA sensing instruments, including implementation, performance, and application from the perspectives of circuits to systems. The novel and significant applications to healthcare are discussed. Three types of EMA sensors are presented: (1) Chip-based radar sensors for health status monitoring, (2) Thermo-acoustic sensing instruments for biomedical applications, and (3) Photoacoustic (PA) sensing and imaging systems, including dedicated reconstruction algorithms were reviewed from time-domain, frequency-domain, time-reversal, and model-based solutions. The future of EMA techniques fo...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

A Multimodal and Multifunctional CMOS Cellular Interfacing Array for Digital Physiology and Pathology Featuring an Ultra Dense Pixel Array and Reconfigurable Sampling Rate
The article presents a fully integrated multimodal and multifunctional CMOS biosensing/actuating array chip and system for multi-dimensional cellular/tissue characterization. The CMOS chip supports up to 1,568 simultaneous parallel readout channels across 21,952 individually addressable multimodal pixels with 13 μm × 13 μm 2-D pixel pitch along with 1,568 Pt reference electrodes. These features allow the CMOS array chip to perform multimodal physiological measurements on living cell/tissue samples with both high throughput and single-cell resolution. Each pixel supports three sensi...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

A CMOS Microelectrode Array System With Reconfigurable Sub-Array Multiplexing Architecture Integrating 24,320 Electrodes and 380 Readout Channels
This article presents a CMOS microelectrode array (MEA) system with a reconfigurable sub-array multiplexing architecture using the time-division multiplexing (TDM) technique. The system consists of 24,320 TiN electrodes with 17.7 μm-pitch pixels and 380 column-parallel readout channels including a low-noise amplifier, a programmable gain amplifier, and a 10-b successive approximation register analog to digital converter. Readout channels are placed outside the pixel for high spatial resolution, and a flexible structure to acquire neural signals from electrodes selected by configuring in-pixel memory is realized. In ...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

A Scalable CMOS Molecular Electronics Chip for Single-Molecule Biosensing
This work reports the first CMOS molecular electronics chip. It is configured as a biosensor, where the primary sensing element is a single molecule “molecular wire” consisting of a ∼100 GΩ, 25 nm long alpha-helical peptide integrated into a current monitoring circuit. The engineered peptide contains a central conjugation site for attachment of various probe molecules, such as DNA, proteins, enzymes, or antibodies, which program the biosensor to detect interactions with a specific target molecule. The current through the molecular wire under a dc applied voltage is monitored with millisecond tem...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

An 18.6-$mu $W/Ch TDM-Based 8-Channel Noncontact ECG Recording IC With Common-Mode Interference Suppression
This paper presents an 8-channel electrocardiogram (ECG) monitoring integrated circuit (IC) controlled by time-division multiplexing (TDM). The proposed TDM compensates the electrode DC offsets by forming an individual discrete-time feedback loop per channel while sharing an analog frontend. This enables a chopping-free open-loop amplification, achieving a high input impedance suitable for a noncontact ECG monitoring. In addition, a common-mode interference (CMI) cancellation scheme is also introduced in the proposed TDM schedule for the realization of a pseudo-driven-right leg (DRL) in a multichannel environment. The desi...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

A Wireless Soil pH and Conductance Monitoring Chip Powered by Soil Microbial and Photovoltaic Energy Cells
This paper presents an energy-autonomous wireless soil pH and electrical conductance measurement IC powered by soil microbial and photovoltaic energy. The chip integrates highly efficient dual-input, dual-output power management units, sensor readout circuits, a wireless receiver, and a transmitter. The design scavenges ambient energy with a maximal power point tracking mechanism while achieving a peak efficiency of 81.3% and the efficiency is more than 50% over the 0.05–14 mW load range. The sensor readout IC achieves a sensitivity of −8.8 kHz/pH and 6 kHz·m/S, a noise floo...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

A Sparse Sampling Sensor Front-End IC for Low Power Continuous SpO$_{2}$ & HR Monitoring
Photoplethysmography (PPG) is an attractive method to acquire vital signs such as heart rate and blood oxygenation and is frequently used in clinical and at-home settings. Continuous operation of health monitoring devices demands a low power sensor that does not restrict the device battery life. Silicon photodiodes (PD) and LEDs are commonly used as interface devices in PPG sensors; however, using of flexible organic devices can enhance the sensor conformality and reduce the cost of fabrication. In most PPG sensors, most of system power consumption is concentrated in powering LEDs, traditionally consuming mWs. Using organi...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

Editorial Selected Papers From the 2022 IEEE International Solid-State Circuits Conference
Presents select papers that were presented at the 2022 IEEE International Solid-State Circuits Conference. (Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Circuits and Systems Publication Information
(Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

Table of Contents
(Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research