Design of a Low-Power Ground-Free Analog Front End for ECG Acquisition
This article presents the design of a low-power ground-free (two-electrode) analog front end (AFE) for ECG acquisition. At the heart of the design is the low-power common-mode interference (CMI) suppression circuit (CMI-SC) to help minimize the common-mode input swing and prevent turning on the ESD diodes at the input of the AFE. Fabricated in a 0.18-$mu$m CMOS process with an active area of 0.8 $text{mm}^{2}$, the two-electrode AFE can tolerate CMI of up to 12 $V_text{pp}$, while consuming only 6.55 $mu$W of power from a 1.2-V supply and exhibiting 1.67 $mu mathrm{V_{rms}}$ of input-referred noise in a 1–100 Hz ban...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

A 5.3 pJ/Spike CMOS Neural Array Employing Time-Modulated Axon-Sharing and Background Mismatch Calibration Techniques
Inspired by the human brain, spiking neuron networks are promising to realize energy-efficient and low-latency neuromorphic computing. However, even state-of-the-art silicon neurons are orders of magnitude worse than biological neurons in terms of area and power consumption due to the limitations. Moreover, limited routing in typical CMOS processes is another challenge for realizing the fully-parallel high-throughput synapse connections compared to biological synapses. This paper presents an SNN circuit that utilizes resource-sharing techniques to address the two challenges. Firstly, a comparator sharing neuron circuit wit...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

Design of Dual-Configuration Dual-Mode Stimulator in Low-Voltage CMOS Process for Neuro-Modulation
A dual-configuration dual-mode stimulator for neuro-modulation is proposed and designed. All the electrical stimulation patterns that frequently used for neuro-modulation can be generated by the proposed stimulator chip. Dual-configuration represents the bipolar or monopolar structure, meanwhile dual-mode stands for the current or voltage output. No matter what stimulation circumstance is chosen, biphasic or monophasic waveforms can be fully supported by the proposed stimulator chip. The stimulator chip with 4 stimulation channels has been fabricated in 0.18-μm 1.8-V/3.3-V low-voltage CMOS process with common...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

An Ingestible Pill With CMOS Fluorescence Sensor Array, Bi-Directional Wireless Interface and Packaged Optics for in-Vivo Bio-Molecular Sensing
The article presents for the first time a pill-based ingestible electronics with CMOS integrated multiplexed fluorescence bio-molecular sensor arrays, bi-directional wireless communication and packaged optics in a FDA-approved capsule for in-vivo bio-molecular sensing. The silicon chip integrates both the sensor array, and the ultra-low-power (ULP) wireless system that allows offloading sensor computing to an external base station that can reconfigure the sensor measurement time, and its dynamic range, allowing optimized high sensitivity measurement under low power consumption. The integrated receiver achieves −59 d...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

Efficient Digital Realization of Endocrine Pancreatic $beta$-Cells
The accurate implementation of biological neural networks, which is one of the important areas of research in the field of neuromorphic, can be studied in the case of diseases, embedded systems, the study of the function of neurons in the nervous system, and so on. The pancreas is one of the main organs of human that performs important and vital functions in the body. One part of the pancreas is an endocrine gland and produces insulin, while another part is an exocrine gland that produces enzymes for digesting fats, proteins and carbohydrates. In this paper, an optimal digital hardware implementation for pancreatic $beta$-...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

Comprehensive Comparison of Continuous-Wave and Linear-Frequency-Modulated Continuous-Wave Radars for Short-Range Vital Sign Monitoring
Conclusions show that this performance does not depend on the selected working frequency. (Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

Recent Advances in CMOS Electrochemical Biosensor Design for Microbial Monitoring: Review and Design Methodology
Rapid, high-sensitivity, and real-time characterization of microorganisms plays a significant role in several areas, including clinical diagnosis, human healthcare, early detection of outbreaks, and the protection of living beings. Integrating microbiology and electrical engineering promises the development of low-cost, miniaturized, autonomous, and high-sensitivity sensors to quantify and characterize bacterial strains at various concentrations. Electrochemical-based biosensors are receiving particular attention in microbiological applications among the different biosensing devices. Several approaches have been adopted to...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

tinyRadar for Fitness: A Contactless Framework for Edge Computing
Healthcare technology is evolving from a conventional hub-based system to a personalized healthcare system accelerated by rapid advancements in smart fitness trackers. Modern fitness trackers are mostly lightweight wearables and can monitor the user's health round the clock, supporting ubiquitous connectivity and real-time tracking. However, prolonged skin contact with wearable trackers can cause discomfort. They are susceptible to false results and breach of privacy due to the exchange of user's personal data over the internet. We propose tinyRadar, a novel on-edge millimeter wave (mmWave) radar-based fitnes...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

Software-Hardware Co-Design for Energy-Efficient Continuous Health Monitoring via Task-Aware Compression
Low power consumption associated with data transmission and processing of wearable/implantable devices is crucial to ensure the usability of continuous health monitoring systems. In this paper, we propose a novel health monitoring framework where the signal acquired is compressed in a task-aware manner to preserve task-relevant information at the sensor end with a low computation cost. The resulting compressed signals can be transmitted with significantly lower bandwidth, analyzed directly without a dedicated reconstruction process, or reconstructed with high fidelity. Also, we propose a dedicated hardware architecture wit...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

FPGA-Based In-Vivo Calcium Image Decoding for Closed-Loop Feedback Applications
Miniaturized calcium imaging is an emerging neural recording technique that has been widely used for monitoring neural activity on a large scale at a specific brain region of rats or mice. Most existing calcium-image analysis pipelines operate offline. This results in long processing latency, making it difficult to realize closed-loop feedback stimulation for brain research. In recent work, we have proposed an FPGA-based real-time calcium image processing pipeline for closed-loop feedback applications. It can perform real-time calcium image motion correction, enhancement, fast trace extraction, and real-time decoding from ...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

A Real-Time Respiration Monitoring System Using WiFi Sensing Based on the Concentric Circle Model
This paper proposes and experimentally validates a novel concentric circle (CC) model for indoor WiFi sensing. By setting the transmitter and receiver together, the perception model becomes concentric circles with equal spacing, eliminating the blind zone and unequal radial sensitivity problems of the Fresnel zone (FZ) model. Then a human respiratory monitoring system is developed based on this model, which executes the following steps: (1) Principal component analysis (PCA) is applied to the channel state information ratio (CSIR) as a preprocessing to extract the components related to human activities. (2) Human presence ...
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

Guest Editorial—Selected Papers From the 2022 IEEE International Symposium on Circuits and Systems
The IEEE International Symposium on Circuits and Systems (ISCAS) is the flagship conference of the IEEE Circuits and Systems (CAS) Society and the world's premiere forum for researchers in the fields of theory, design and implementation of circuits and systems. The IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS (TBioCAS) highlights selected papers from ISCAS on topics related to biological and healthcare applications. This special section features four selected papers from ISCAS 2022, held in Austin, Texas, USA from May 28 to June 1, 2022. (Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Circuits and Systems Publication Information
(Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

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Source: IEEE Transactions on Biomedical Circuits and Systems - April 1, 2023 Category: Biomedical Engineering Source Type: research

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Source: IEEE Transactions on Biomedical Circuits and Systems - February 1, 2023 Category: Biomedical Engineering Source Type: research