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The role of Immunity in Fabry Disease and Hypertension: A Review of a Novel Common Pathway
AbstractFabry disease is a progressive, X-linked inherited lysosomal storage disorder where accumulation of glycosphingolipids increases the risk for early cardiovascular complications, including heart failure, stroke, and end stage renal disease. Besides disease-specific therapy, blood pressure (BP) control is of central importance in Fabry disease to reduce disease progression and improve prognosis. Both Fabry disease and hypertension are characterized by the activation of the innate component of the immune system, with Toll-like receptor 4 (TLR4) as a common trigger to the inflammatory cascade. The renin-angiotensin sys...
Source: High Blood Pressure and Cardiovascular Prevention - October 12, 2020 Category: Cardiology Source Type: research

The Importance of Reducing Salt Intake in Children, While Respecting the Correct Iodine Supplementation. The Pediatricians' Point of View
(Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - October 2, 2020 Category: Cardiology Source Type: research

Abstracts from 2020 national congress of the Italian Society of Hypertension (SIIA)
(Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - September 30, 2020 Category: Cardiology Source Type: research

Amlodipine Compared with Benidipine in the Management of Hypertension: A Systematic Review and Meta-Analysis
ConclusionsFinally we conclude that benidipine seems to show more positive and promising results in the management of hypertensive patients with chronic kidney disease. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - September 30, 2020 Category: Cardiology Source Type: research

Hypertensive Emergency in a Woman with Systemic Sclerosis
We present a clinical case of SRC with a typical presentation of hypertensive emergency and acute kidney injury. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - September 30, 2020 Category: Cardiology Source Type: research

Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes
AbstractEpidemiological studies have documented a high incidence of diabetes in hypertensive patients.Insulin resistance is defined as a less than expected biologic response to a given concentration of the hormone and plays a pivotal role in the pathogenesis of diabetes. However, over the last decades, it became evident that insulin resistance is not merely a metabolic abnormality, but is a complex and multifaceted syndrome that can also affect blood pressure homeostasis. The dysregulation of neuro-humoral and neuro-immune systems is involved in the pathophysiology of both insulin resistance and hypertension. These mechani...
Source: High Blood Pressure and Cardiovascular Prevention - September 21, 2020 Category: Cardiology Source Type: research

Impact of Treatment with Renin –Angiotensin System Inhibitors on Clinical Outcomes in Hypertensive Patients Hospitalized with COVID-19
ConclusionsThe use of ACEi or ARB was associated with less incidence of all-cause death during hospitalisation among hypertensive patients admitted with COVID-19 respiratory infection. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - September 18, 2020 Category: Cardiology Source Type: research

COVID-19 and the Forgotten Majority
(Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - August 28, 2020 Category: Cardiology Source Type: research

Relationship between circulating leptin levels and arterial stiffness: a systematic review and meta-analysis of observational studies
ConclusionThe results of this meta-analysis indicate that leptin is positively associated with arterial stiffness. This association significantly adds to the recognized value of leptin in cardiovascular disease. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - August 10, 2020 Category: Cardiology Source Type: research

Physical Exercise Combined with Antihypertensive Drug Therapy on Left Ventricular Hypertrophy: Systematic Review and Meta-Analysis
ConclusionThe antihypertensive therapy combined with physical exercise practice can reduce LV mass and HR. Therefore, combined therapy prescription should be considered for prevention and treatment of LV hypertrophy of hypertensive subjects. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - August 9, 2020 Category: Cardiology Source Type: research

Food Consumption is Associated with Hyperuricemia in Boys
ConclusionThe knowledge of food patterns which are predisposing factors for the increase in serum uric acid levels is important for the implementation of strategies and public health policies for health promotion among children and adolescents. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - August 8, 2020 Category: Cardiology Source Type: research

Blood Pressure, Congestion and Heart Failure with Preserved Ejection Fraction Among Patients with and Without Type 2 Diabetes Mellitus. A Cluster Analysis Approach from the Observational Registry DICUMAP
ConclusionsPatients with HFpEF and T2DM expressed two different profiles depending on neurohormonal activation and arterial stiffness with prognostic implications. Patients without T2DM showed three profiles depending on ABPM pattern, kidney disease and PP without prognostic repercussion. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - August 7, 2020 Category: Cardiology Source Type: research

New Mechanisms of Vascular Dysfunction in Cardiometabolic Patients: Focus on Epigenetics
AbstractEpigenetic processing takes centre stage in cardiometabolic diseases (obesity, metabolic syndrome, type 2 diabetes, hypertension), where it participates in adiposity, inflammation, endothelial dysfunction, vascular insulin resistance and atherosclerosis. Epigenetic modifications, defined as heritable changes in gene expression that do not entail mutation in the DNA sequence, are mainly induced by environmental stimuli (stress, pollution, cigarette smoking) and are gaining considerable interest due to their causal role in cardiovascular disease, and their amenability to pharmacological intervention. Importantly, epi...
Source: High Blood Pressure and Cardiovascular Prevention - July 31, 2020 Category: Cardiology Source Type: research

Recommendations for Cardiovascular Prevention During the Sars-Cov-2 Pandemic: An Executive Document by the Board of the Italian Society of Cardiovascular Prevention
AbstractIn 2020, the Sars-Cov-2 pandemic is causing a huge and dramatic impact on healthcare systems worldwide. During this emergency, fragile patients suffering from other comorbidities, especially patients susceptible to or affected by cardiovascular disease, are the ones most exposed to the poorer outcomes. Therefore, it is still mandatory to continue to strictly adhere to the rules of cardiovascular prevention. This document aims to provide all doctors with simple and clear recommendations in order to spread useful messages to the widest number of subjects in order to continue the battle against cardiovascular diseases...
Source: High Blood Pressure and Cardiovascular Prevention - July 29, 2020 Category: Cardiology Source Type: research

Are Unattended Blood Pressure Measurements Necessary in All Patients Visiting an Outpatient Cardiology Clinic?
ConclusionsUnattended BP was lower than attended BP in the majority of hypertensive patients. However, it was useful only in a small percentage of non diabetic hypertensive patients in order to take appropriate treatment plan decisions. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - July 26, 2020 Category: Cardiology Source Type: research