Unveiling the expansion of keratin genes in lungfishes: a possible link to terrestrial adaptation
Genes Genet Syst. 2023 Oct 17. doi: 10.1266/ggs.23-00188. Online ahead of print.ABSTRACTKeratins are intermediate filament proteins that are important for epidermal strength and protection from desiccation. Keratin genes are highly duplicated and have diversified by forming two major clusters in the genomes of terrestrial vertebrates. The keratin genes of lungfishes, the closest fish to tetrapods, have not been studied at the genomic level, despite the importance of lungfishes in terrestrial adaptation. Here, we identified keratin genes in the genomes of two lungfish species and performed syntenic and phylogenetic analyses...
Source: Genes and Genetic Systems - October 19, 2023 Category: Genetics & Stem Cells Authors: Yuki Kimura Masato Nikaido Source Type: research
Unveiling the expansion of keratin genes in lungfishes: a possible link to terrestrial adaptation
Genes Genet Syst. 2023 Oct 17. doi: 10.1266/ggs.23-00188. Online ahead of print.ABSTRACTKeratins are intermediate filament proteins that are important for epidermal strength and protection from desiccation. Keratin genes are highly duplicated and have diversified by forming two major clusters in the genomes of terrestrial vertebrates. The keratin genes of lungfishes, the closest fish to tetrapods, have not been studied at the genomic level, despite the importance of lungfishes in terrestrial adaptation. Here, we identified keratin genes in the genomes of two lungfish species and performed syntenic and phylogenetic analyses...
Source: Genes and Genetic Systems - October 19, 2023 Category: Genetics & Stem Cells Authors: Yuki Kimura Masato Nikaido Source Type: research
SARS-CoV-2 HaploGraph: visualization of SARS-CoV-2 haplotype spread in Japan
Genes Genet Syst. 2023 Oct 14. doi: 10.1266/ggs.23-00085. Online ahead of print.ABSTRACTSince the early phase of the coronavirus disease 2019 (COVID-19) pandemic, a number of research institutes have been sequencing and sharing high-quality severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes to trace the route of infection in Japan. To provide insight into the spread of COVID-19, we developed a web platform named SARS-CoV-2 HaploGraph to visualize the emergence timing and geographical transmission of SARS-CoV-2 haplotypes. Using data from the GISAID EpiCoV database as of June 4, 2022, we created a haplotyp...
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: So Nakagawa Toshiaki Katayama Lihua Jin Jiaqi Wu Kirill Kryukov Rise Oyachi Junko S Takeuchi Takatomo Fujisawa Satomi Asano Momoka Komatsu Jun-Ichi Onami Takashi Abe Masanori Arita Source Type: research
High-speed system to generate congenic strains in medaka
Genes Genet Syst. 2023 Oct 13. doi: 10.1266/ggs.23-00075. Online ahead of print.ABSTRACTThe congenic strain, an inbred strain containing a small genomic region from another strain, is a powerful tool to assess the phenotypic effect of polymorphisms and/or mutations in the substituted genomic region. Recent substantial progress in the genetic studies of complex traits increases the necessity of congenic strains and, therefore, a quick breeding system for congenic strains has become increasingly important in model organisms such as mouse and medaka. Traditionally, more than ten generations are necessary to produce a congenic...
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: Minori Shinya Tetsuaki Kimura Kiyoshi Naruse Source Type: research
A four-gene-based methylation signature associated with lymph node metastasis predicts overall survival in lung squamous cell carcinoma
This study identified several specific methylation markers associated with LNM in LUSC and generated a prognostic model to predict overall survival for LUSC patients.PMID:37839873 | DOI:10.1266/ggs.22-00111 (Source: Genes and Genetic Systems)
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: Yufei Deng Lifeng Liu Xia Xiao Yin Zhao Source Type: research
SARS-CoV-2 HaploGraph: visualization of SARS-CoV-2 haplotype spread in Japan
Genes Genet Syst. 2023 Oct 14. doi: 10.1266/ggs.23-00085. Online ahead of print.ABSTRACTSince the early phase of the coronavirus disease 2019 (COVID-19) pandemic, a number of research institutes have been sequencing and sharing high-quality severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes to trace the route of infection in Japan. To provide insight into the spread of COVID-19, we developed a web platform named SARS-CoV-2 HaploGraph to visualize the emergence timing and geographical transmission of SARS-CoV-2 haplotypes. Using data from the GISAID EpiCoV database as of June 4, 2022, we created a haplotyp...
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: So Nakagawa Toshiaki Katayama Lihua Jin Jiaqi Wu Kirill Kryukov Rise Oyachi Junko S Takeuchi Takatomo Fujisawa Satomi Asano Momoka Komatsu Jun-Ichi Onami Takashi Abe Masanori Arita Source Type: research
High-speed system to generate congenic strains in medaka
Genes Genet Syst. 2023 Oct 13. doi: 10.1266/ggs.23-00075. Online ahead of print.ABSTRACTThe congenic strain, an inbred strain containing a small genomic region from another strain, is a powerful tool to assess the phenotypic effect of polymorphisms and/or mutations in the substituted genomic region. Recent substantial progress in the genetic studies of complex traits increases the necessity of congenic strains and, therefore, a quick breeding system for congenic strains has become increasingly important in model organisms such as mouse and medaka. Traditionally, more than ten generations are necessary to produce a congenic...
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: Minori Shinya Tetsuaki Kimura Kiyoshi Naruse Source Type: research
A four-gene-based methylation signature associated with lymph node metastasis predicts overall survival in lung squamous cell carcinoma
This study identified several specific methylation markers associated with LNM in LUSC and generated a prognostic model to predict overall survival for LUSC patients.PMID:37839873 | DOI:10.1266/ggs.22-00111 (Source: Genes and Genetic Systems)
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: Yufei Deng Lifeng Liu Xia Xiao Yin Zhao Source Type: research
SARS-CoV-2 HaploGraph: visualization of SARS-CoV-2 haplotype spread in Japan
Genes Genet Syst. 2023 Oct 14. doi: 10.1266/ggs.23-00085. Online ahead of print.ABSTRACTSince the early phase of the coronavirus disease 2019 (COVID-19) pandemic, a number of research institutes have been sequencing and sharing high-quality severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes to trace the route of infection in Japan. To provide insight into the spread of COVID-19, we developed a web platform named SARS-CoV-2 HaploGraph to visualize the emergence timing and geographical transmission of SARS-CoV-2 haplotypes. Using data from the GISAID EpiCoV database as of June 4, 2022, we created a haplotyp...
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: So Nakagawa Toshiaki Katayama Lihua Jin Jiaqi Wu Kirill Kryukov Rise Oyachi Junko S Takeuchi Takatomo Fujisawa Satomi Asano Momoka Komatsu Jun-Ichi Onami Takashi Abe Masanori Arita Source Type: research
High-speed system to generate congenic strains in medaka
Genes Genet Syst. 2023 Oct 13. doi: 10.1266/ggs.23-00075. Online ahead of print.ABSTRACTThe congenic strain, an inbred strain containing a small genomic region from another strain, is a powerful tool to assess the phenotypic effect of polymorphisms and/or mutations in the substituted genomic region. Recent substantial progress in the genetic studies of complex traits increases the necessity of congenic strains and, therefore, a quick breeding system for congenic strains has become increasingly important in model organisms such as mouse and medaka. Traditionally, more than ten generations are necessary to produce a congenic...
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: Minori Shinya Tetsuaki Kimura Kiyoshi Naruse Source Type: research
A four-gene-based methylation signature associated with lymph node metastasis predicts overall survival in lung squamous cell carcinoma
This study identified several specific methylation markers associated with LNM in LUSC and generated a prognostic model to predict overall survival for LUSC patients.PMID:37839873 | DOI:10.1266/ggs.22-00111 (Source: Genes and Genetic Systems)
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: Yufei Deng Lifeng Liu Xia Xiao Yin Zhao Source Type: research
SARS-CoV-2 HaploGraph: visualization of SARS-CoV-2 haplotype spread in Japan
Genes Genet Syst. 2023 Oct 14. doi: 10.1266/ggs.23-00085. Online ahead of print.ABSTRACTSince the early phase of the coronavirus disease 2019 (COVID-19) pandemic, a number of research institutes have been sequencing and sharing high-quality severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes to trace the route of infection in Japan. To provide insight into the spread of COVID-19, we developed a web platform named SARS-CoV-2 HaploGraph to visualize the emergence timing and geographical transmission of SARS-CoV-2 haplotypes. Using data from the GISAID EpiCoV database as of June 4, 2022, we created a haplotyp...
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: So Nakagawa Toshiaki Katayama Lihua Jin Jiaqi Wu Kirill Kryukov Rise Oyachi Junko S Takeuchi Takatomo Fujisawa Satomi Asano Momoka Komatsu Jun-Ichi Onami Takashi Abe Masanori Arita Source Type: research
High-speed system to generate congenic strains in medaka
Genes Genet Syst. 2023 Oct 13. doi: 10.1266/ggs.23-00075. Online ahead of print.ABSTRACTThe congenic strain, an inbred strain containing a small genomic region from another strain, is a powerful tool to assess the phenotypic effect of polymorphisms and/or mutations in the substituted genomic region. Recent substantial progress in the genetic studies of complex traits increases the necessity of congenic strains and, therefore, a quick breeding system for congenic strains has become increasingly important in model organisms such as mouse and medaka. Traditionally, more than ten generations are necessary to produce a congenic...
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: Minori Shinya Tetsuaki Kimura Kiyoshi Naruse Source Type: research
A four-gene-based methylation signature associated with lymph node metastasis predicts overall survival in lung squamous cell carcinoma
This study identified several specific methylation markers associated with LNM in LUSC and generated a prognostic model to predict overall survival for LUSC patients.PMID:37839873 | DOI:10.1266/ggs.22-00111 (Source: Genes and Genetic Systems)
Source: Genes and Genetic Systems - October 15, 2023 Category: Genetics & Stem Cells Authors: Yufei Deng Lifeng Liu Xia Xiao Yin Zhao Source Type: research
Development of an isogenic human cell trio that models polyglutamine disease
This study thus demonstrates the potential of UKiS, which is a beneficial platform for the efficient development of cell models not only for polyQ diseases but also for any other genetic diseases, which may accelerate our deeper understanding of disease mechanisms and cell-based screening for therapeutic drugs.PMID:37821389 | DOI:10.1266/ggs.22-00030 (Source: Genes and Genetic Systems)
Source: Genes and Genetic Systems - October 11, 2023 Category: Genetics & Stem Cells Authors: Tomoyuki Ohno Takeshi Nakane Taichi Akase Hikaru Kurasawa Yasunori Aizawa Source Type: research
