Artificial Intelligence Research and Development for Application in Video Capsule Endoscopy
Artificial intelligence (AI) research for medical applications has expanded quickly. Advancements in computer processing now allow for the development of complex neural network architectures (eg, convolutional neural networks) that are capable of extracting and learning complex features from massive data sets, including large image databases. Gastroenterology and endoscopy are well suited for AI research. Video capsule endoscopy is an ideal platform for AI model research given the large amount of data produced by each capsule examination and the annotated databases that are already available. Studies have demonstrated high...
Source: Gastrointestinal Endoscopy Clinics of North America - February 15, 2021 Category: Gastroenterology Authors: Peter Sullivan, Shradha Gupta, Patrick D. Powers, Neil B. Marya Source Type: research

The Cost-Effectiveness of Video Capsule Endoscopy
The development of video capsule endoscopy (VCE) has allowed for visualization of parts of the gastrointestinal tract generally not readily accessible by noninvasive means. Its ease of use has proved useful in diagnosing and managing various small bowel inflammatory disorders. Continued technological evolution of VCE has paved the way for use in small intestinal bleeding and in patients with acute gastrointestinal bleeding. A detailed analysis of costs associated with VCE has demonstrated its ability to promote efficient allocation of health care resources. Further work is needed regarding development of a universal infras...
Source: Gastrointestinal Endoscopy Clinics of North America - February 15, 2021 Category: Gastroenterology Authors: Salmaan Jawaid Source Type: research

Preparation, Timing, Prokinetics, and Surface Agents in Video Capsule Endoscopy
There is a trend in data to support active preparation for video capsule endoscopy (VCE), but the timing of this remains unclear. Split dosing may be the most efficacious preparation. Study methodology continues to evolve, with increased use of standardized scales, with the addition of diagnostic yield as an outcome. The use of adjuncts has not been detrimental, but their value has not been proved to improve outcomes of VCE. (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - February 15, 2021 Category: Gastroenterology Authors: Elizabeth Squirell, Michelle Ricci, Lawrence Hookey Source Type: research

Video Capsule Endoscopy: Now and the Future
My first interaction with video capsule endoscopy was in early 2001, when I was invited to a marketing focus group run on behalf of a startup company by the name of Given Imaging (Yokneam, Israel). The little pill-like device that was demonstrated took rather fuzzy low-resolution images of the small intestine from pylorus to ileocecal valve. This was to be an answer to a prayer. I and a few others had been struggling with different ways to access the small bowel for more than a decade, particularly for people who had small intestinal bleeding. (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - February 8, 2021 Category: Gastroenterology Authors: David R. Cave Tags: Preface Source Type: research

Video Capsule Endoscopy: Safe, Effective, Evolving, Here to Stay
It ’s interesting when a completely new technology arrives on the scene in gastrointestinal endoscopy. There are always the doubters, the head scratchers, the worriers, and then the early adopters and pioneers, who become essential to potential success. Two decades ago, video capsule endoscopy was a completely new technology: a tiny video camera, transmitter, and battery jammed into a pill-sized cylinder that could be swallowed by most people, and easily pass through the entire gastrointestinal tract. (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - February 8, 2021 Category: Gastroenterology Authors: Charles J. Lightdale Tags: Foreword Source Type: research

Progress in Screening for Barrett ’s Esophagus
The rapid increase in the incidence of esophageal adenocarcinoma in Western populations over the past 4  decades and its associated poor prognosis, unless detected early has generated great interest in screening for the precursor lesion Barrett’s esophagus (BE). Recently, there have been significant developments in imaging-based modalities and esophageal cell-sampling devices coupled with biomarker assays. In this review, the authors discuss the rationale for screening for BE and the factors to consider for targeting the at-risk population. They also explore future avenues for research in this area. (Source: Gastrointes...
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Authors: Wei Keith Tan, Anamay N. Sharma, Amitabh Chak, Rebecca C. Fitzgerald Source Type: research

Role of Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection in the Management of Barrett ’s Related Neoplasia
Endoscopic resection has been proven to be safe and highly effective for removing early neoplastic lesions in Barrett esophagus. It enables accurate histopathological assessment and is therefore considered as the cornerstone in the endoscopic work-up for patients with Barrett neoplasia. Various techniques are available to perform endoscopic resection. Multiband mucosectomy is the most commonly used resection technique. However, endoscopic submucosal dissection is gaining ground in the Western world. Endoscopic resection for low-risk submucosal lesions already is fully justified. Future studies have to point out whether end...
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Authors: Esther A. Nieuwenhuis, Oliver Pech, Jacques J.G.H.M. Bergman, Roos E. Pouw Source Type: research

A Practical Approach to Refractory and Recurrent Barrett's Esophagus
Endoscopic eradication therapy (EET) is recommended for patients with Barrett ’s esophagus (BE)-associated neoplasia and is effective in achieving complete eradication of intestinal metaplasia (CE-IM). However, BE that is refractory to EET, defined as partial or no improvement in dysplasia after less than or equal to 3 ablative sessions, and the development of recurrence po st-EET is not uncommon. Identification of refractory BE or recurrent intestinal metaplasia should prompt esophageal physiologic testing and modification of antireflux strategy, as appropriate. In patients who ultimately fail standard EET despite optim...
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Authors: Domenico A. Farina, Ashwinee Condon, Srinadh Komanduri, V. Raman Muthusamy Source Type: research

Optimizing Outcomes with Radiofrequency Ablation of Barrett's Esophagus
The treatment of early Barrett ’s esophagus (BE) has undergone a paradigm shift from surgical subtotal esophagectomy to organ-saving endoluminal treatment. Over the past 15 years, several high-quality studies were conducted to assess safe oncological outcome of endoscopic resection of mucosal adenocarcinoma and high-grade dysp lasia. It became clear that add-on ablative therapy with radiofrequency ablation (RFA) significantly reduces recurrence risk of neoplasia after resection. In this review, we highlight the most essential elements to optimize outcomes of RFA of BE, addressing the correct indication and patient selec...
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Authors: Philippe Leclercq, Raf Bisschops Source Type: research

Updates in Cryotherapy for Barrett ’s Esophagus
Cryotherapy is an ablation modality relying on freeze-thaw cycles to promote cell death through intracellular ice crystal formation, ischemia, and apoptosis. Currently, 2 different cryotherapy systems are available for esophageal use. The first is cryospray ablation, which involves repetitive applications of liquid nitrogen. The second system, cryoballoon ablation, freezes the esophageal mucosa with liquid nitrous oxide using a compliant balloon. To date, studies have shown that cryotherapy is an effective and safe method for eradicating Barrett ’s esophagus; however, larger prospective series with longer follow-up are w...
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Authors: Charlotte N. Frederiks, Marcia Irene Canto, Bas L.A.M. Weusten Source Type: research

Advances in Barrett ’s Esophagus
GASTROINTESTINAL ENDOSCOPY CLINICS OF NORTH AMERICA (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Authors: Sachin Wani Source Type: research

Copyright
ELSEVIER (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Source Type: research

Contributors
CHARLES J. LIGHTDALE, MD (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Source Type: research

Contents
Charles J. Lightdale (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Source Type: research

Forthcoming Issues
Video Capsule Endoscopy (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - November 17, 2020 Category: Gastroenterology Source Type: research