European Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Stabilization effects of saccharides in protein formulations: A review of sucrose, trehalose, cyclodextrins and dextrans
Eur J Pharm Sci. 2023 Nov 2;192:106625. doi: 10.1016/j.ejps.2023.106625. Online ahead of print.ABSTRACTSaccharides are a popular group of stabilizers in liquid, frozen and freeze dried protein formulations. The current work reviewed the stabilization mechanisms of three groups of saccharides: (i) Disaccharides, specifically sucrose and trehalose; (ii) cyclodextrins (CDs), a class of cyclic oligosaccharides; and (iii) dextrans, a class of polysaccharides. Compared to sucrose, trehalose exhibits a more pronounced preferential exclusion effect in liquid protein formulations, due to its stronger interaction with water molecule...
Source: European Journal of Pharmaceutical Sciences - November 2, 2023 Category: Drugs & Pharmacology Authors: Jinghan Li Hongyue Wang Lushan Wang Dongyue Yu Xiangrong Zhang Source Type: research

Novel nanomicelle butenafine formulation for ocular drug delivery against fungal keratitis: In Vitro and In Vivo study
Eur J Pharm Sci. 2023 Nov 2;192:106629. doi: 10.1016/j.ejps.2023.106629. Online ahead of print.ABSTRACTFungal keratitis (FK) is a serious infectious corneal disease that leads to blindness. Butenafine (BTF) is an allylamine drug with high antifungal activity, but its poor water solubility and low bioavailability limit its clinical application in ophthalmology. To increase its aqueous solubility and corneal permeability, butenafine was encapsulated in d-ɑ-tocopheryl polyethylene glycol succinate (TPGS) polymeric nanomicelles to improve the bioavailability of the drug for the treatment of FK. Butenafine was successfully fab...
Source: European Journal of Pharmaceutical Sciences - November 2, 2023 Category: Drugs & Pharmacology Authors: Ping Lu Zhen Liang Zhen Zhang Jingjing Yang Fei Song Tianyang Zhou Jingguo Li Junjie Zhang Source Type: research

Stabilization Effects of Saccharides in Protein Formulations: a Review of Sucrose, Trehalose, Cyclodextrins and Dextrans
Eur J Pharm Sci. 2023 Oct 31:106625. doi: 10.1016/j.ejps.2023.106625. Online ahead of print.ABSTRACTSaccharides are a popular group of stabilizers in liquid, frozen and freeze dried protein formulations. The current work reviewed the stabilization mechanisms of three groups of saccharides: (i) Disaccharides, specifically sucrose and trehalose; (ii) cyclodextrins (CDs), a class of cyclic oligosaccharides; and (iii) dextrans, a class of polysaccharides. Compared to sucrose, trehalose exhibits a more pronounced preferential exclusion effect in liquid protein formulations, due to its stronger interaction with water molecules. ...
Source: European Journal of Pharmaceutical Sciences - November 2, 2023 Category: Drugs & Pharmacology Authors: Jinghan Li Hongyue Wang Lushan Wang Dongyue Yu Xiangrong Zhang Source Type: research

Novel Nanomicelle Butenafine Formulation for Ocular Drug Delivery against Fungal Keratitis: In Vitro and In Vivo Study
Eur J Pharm Sci. 2023 Oct 31:106629. doi: 10.1016/j.ejps.2023.106629. Online ahead of print.ABSTRACTFungal keratitis (FK) is a serious infectious corneal disease that leads to blindness. Butenafine (BTF) is an allylamine drug with high antifungal activity, but its poor water solubility and low bioavailability limit its clinical application in ophthalmology. To increase its aqueous solubility and corneal permeability, butenafine was encapsulated in D-ɑ-tocopheryl polyethylene glycol succinate (TPGS) polymeric nanomicelles to improve the bioavailability of the drug for the treatment of FK. Butenafine was successfully fabric...
Source: European Journal of Pharmaceutical Sciences - November 2, 2023 Category: Drugs & Pharmacology Authors: Ping Lu Zhen Liang Zhen Zhang Jingjing Yang Fei Song Tianyang Zhou Jingguo Li Junjie Zhang Source Type: research

Safety, tolerability, and pharmacokinetics of oral (S)-oxiracetam in Chinese healthy volunteers: a randomized, double-blind, controlled phase I study
CONCLUSION: (S)-oxiracetam was safe and tolerated with favorable pharmacokinetic profiles at all study doses, providing dosing evidence for further efficacy evaluation.PMID:37898393 | DOI:10.1016/j.ejps.2023.106621 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - October 28, 2023 Category: Drugs & Pharmacology Authors: Ting Zhang Yi Tao Junliang Pu Mingxue Zhu Lei Wan Chengyong Tang Source Type: research

Proteolysis Targeting Chimeras (PROTACs) Based on Celastrol Induce Multiple Protein Degradation for Triple-Negative Breast Cancer Treatment
In this study, we present a novel approach using celastrol (CST)-based Proteolysis Targeting Chimeras (PROTACs) for breast cancer therapy. Through rational design, we have successfully developed compound 6a, a potent multiple protein degrader capable of selectively degrading GRP94 and CDK1/4 in tumor cells via the endogenous ubiquitin-proteasome system. Furthermore, compound 6a has demonstrated remarkable inhibitory effects on cell proliferation and migration, and induction of apoptosis in 4T1 cells through cell cycle arrest and activation of the Bcl-2/Bax/cleaved Caspase-3 apoptotic pathway. In vivo administration of comp...
Source: European Journal of Pharmaceutical Sciences - October 28, 2023 Category: Drugs & Pharmacology Authors: Xuelan Gan Fan Wang Jianguo Luo Yunfei Zhao Yan Wang Chao Yu Jun Chen Source Type: research