Peptides targeting the BTLA-HVEM complex can modulate T cell immune response
Eur J Pharm Sci. 2023 Dec 19:106677. doi: 10.1016/j.ejps.2023.106677. Online ahead of print.ABSTRACTImmune checkpoints secure the proper function of the immune system and the maintenance of the BTLA-HVEM complex, an inhibitory immune checkpoint, is one of the pathways vital for T cell responsiveness to various stimuli. The present study reports the immunomodulatory potential of five peptides targeting the BTLA-HVEM complex on the activity of human T cells. Isolated T cells were exposed to the peptides alone or combined with CD3/CD28 mAb for 72h or 120h. The flow cytometry was used to evaluate the activation markers (CD69, ...
Source: European Journal of Pharmaceutical Sciences - December 21, 2023 Category: Drugs & Pharmacology Authors: Karolina Wojciechowicz Katarzyna Kuncewicz Katarzyna A Lisowska Anna Wardowska Marta Spodzieja Source Type: research

The effect of mixing on the dispersibility of adhesive mixtures for inhalation. Comparison of high shear and Turbula mixers
This study investigates the effect of different mixers and the applicability of the mixing energy (ME) concept to dry powder formulations for inhalation. With the aim to step-wise build and expand this concept, adhesive mixtures of 2% budesonide and lactose carrier were investigated, both with 1% magnesium stearate (MgSt) added in a 'coating' step, and without, the latter referred to as 'naked' formulations. For high shear mixed formulations, the fine particle fraction (FPF) was found to increase with increasing ME up to 60% and thereafter decreased, using the Novolizer device. The data could be well fitted to the modeling...
Source: European Journal of Pharmaceutical Sciences - December 21, 2023 Category: Drugs & Pharmacology Authors: Kyrre Thalberg Love Ivarsson M årten Svensson Peter Elfman Ann Ohlsson Jackie Stuckel Ann-Marie Lyberg Source Type: research

Tetramethylpyrazine-loaded liposomes surrounded by hydrogel based on sodium alginate and chitosan as a multifunctional drug delivery System for treatment of atopic dermatitis
Eur J Pharm Sci. 2023 Dec 19;193:106680. doi: 10.1016/j.ejps.2023.106680. Online ahead of print.ABSTRACTTetramethylpyrazine (TMP) has low bioavailability due to its fast metabolism and short half-life, which is not conducive to transdermal treatment of atopic dermatitis (AD). Therefore, in this study, TMP was encapsulated into liposomes (Lip) by film dispersion method, and then the surface of Lip was modified by sodium alginate (ALG) and chitosan (CS). The tetramethylpyrazine-loaded liposomes in sodium alginate chitosan hydrogel called T-Lip-AC hydrogel. In vitro experiments, we found that T-Lip-AC hydrogel not only had th...
Source: European Journal of Pharmaceutical Sciences - December 21, 2023 Category: Drugs & Pharmacology Authors: Ying Xia Keang Cao Ruoyang Jia Xue Chen Yang Wu Yu Wang Zhiqing Cheng Hongmei Xia Yinxiang Xu Zili Xie Source Type: research

Harmonizing the craft of crafting clinically endorsed small-molecule BCR-ABL tyrosine kinase inhibitors for the treatment of hematological malignancies
In conclusion, the synthesis and utilization of clinically validated small-molecule TKIs targeting BCR-ABL exemplify the transformative power of precision medicine in the treatment of hematological malignancies. This review highlights the evolving landscape of BCR-ABL inhibition and underscores the continuous commitment to refining and expanding the therapeutic repertoire for these devastating diseases.PMID:38114052 | DOI:10.1016/j.ejps.2023.106678 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 19, 2023 Category: Drugs & Pharmacology Authors: Lu Sun Peng-Cheng Yang Li Luan Jin-Feng Sun Ya-Tao Wang Source Type: research

Harmonizing the Craft of Crafting Clinically Endorsed Small-Molecule BCR-ABL Tyrosine Kinase Inhibitors for the Treatment of Hematological Malignancies
In conclusion, the synthesis and utilization of clinically validated small-molecule TKIs targeting BCR-ABL exemplify the transformative power of precision medicine in the treatment of hematological malignancies. This review highlights the evolving landscape of BCR-ABL inhibition and underscores the continuous commitment to refining and expanding the therapeutic repertoire for these devastating diseases.PMID:38114052 | DOI:10.1016/j.ejps.2023.106678 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 19, 2023 Category: Drugs & Pharmacology Authors: Lu Sun Peng-Cheng Yang Li Luan Jin-Feng Sun Ya-Tao Wang Source Type: research

Harmonizing the Craft of Crafting Clinically Endorsed Small-Molecule BCR-ABL Tyrosine Kinase Inhibitors for the Treatment of Hematological Malignancies
In conclusion, the synthesis and utilization of clinically validated small-molecule TKIs targeting BCR-ABL exemplify the transformative power of precision medicine in the treatment of hematological malignancies. This review highlights the evolving landscape of BCR-ABL inhibition and underscores the continuous commitment to refining and expanding the therapeutic repertoire for these devastating diseases.PMID:38114052 | DOI:10.1016/j.ejps.2023.106678 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 19, 2023 Category: Drugs & Pharmacology Authors: Lu Sun Peng-Cheng Yang Li Luan Jin-Feng Sun Ya-Tao Wang Source Type: research

< sup > 18 < /sup > F-labeled somatostatin analogs for somatostatin receptors (SSTRs) targeted PET imaging of neuroendocrine tumors (NETs)
CONCLUSION: Fluorine-18 is widely used as a radionuclide for the production of radiopharmaceuticals for positron emission tomography (PET). Due to its short half-life (T1/2,109.8 min), its ease of production will facilitate the widespread dissemination of this radiopharmaceutical. A high-quality [Al18F]NODA-MPAA-HTA was synthesized with satisfactory yield. This radiopharmaceutical demonstrated higher tumor uptake and better tumor-to-muscle contrast, resulting to excellent image quality. These findings suggest that the novel 18F-labeled somatostatin analogue, [Al18F]NODA-MPAA-HTA, is a promising tool for PET imaging of NETs...
Source: European Journal of Pharmaceutical Sciences - December 17, 2023 Category: Drugs & Pharmacology Authors: Fei Gao Yunhan Zhang MengYi Chen ZhiHao Song RuiLin Dong ShanShan Qiu Chen Shen XiaoYan Huang Hao Geng Weihua Cheng Ji Hu Source Type: research

< sup > 18 < /sup > F-labeled somatostatin analogs for somatostatin receptors (SSTRs) targeted PET imaging of neuroendocrine tumors (NETs)
CONCLUSION: Fluorine-18 is widely used as a radionuclide for the production of radiopharmaceuticals for positron emission tomography (PET). Due to its short half-life (T1/2,109.8 min), its ease of production will facilitate the widespread dissemination of this radiopharmaceutical. A high-quality [Al18F]NODA-MPAA-HTA was synthesized with satisfactory yield. This radiopharmaceutical demonstrated higher tumor uptake and better tumor-to-muscle contrast, resulting to excellent image quality. These findings suggest that the novel 18F-labeled somatostatin analogue, [Al18F]NODA-MPAA-HTA, is a promising tool for PET imaging of NETs...
Source: European Journal of Pharmaceutical Sciences - December 17, 2023 Category: Drugs & Pharmacology Authors: Fei Gao Yunhan Zhang MengYi Chen ZhiHao Song RuiLin Dong ShanShan Qiu Chen Shen XiaoYan Huang Hao Geng Weihua Cheng Ji Hu Source Type: research

Cyclosporine A micellar nasal spray characterization and antiviral action against SARS-CoV-2
In conclusion, this work showed that the developed cyclosporine A-loaded micellar formulations have the potential to be clinically effective against a wide spectrum of coronavirus variants.PMID:38103657 | DOI:10.1016/j.ejps.2023.106673 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 16, 2023 Category: Drugs & Pharmacology Authors: Fabiola Guareschi Elena Del Favero Caterina Ricci Laura Cant ù Martina Brandolini Vittorio Sambri Sara Nicoli Silvia Pescina Davide D'Angelo Irene Rossi Francesca Buttini Ruggero Bettini Fabio Sonvico Source Type: research

High-throughput virtual screening to identify potential small molecule inhibitors of the Z α domain of the adenosine deaminases acting on RNA 1(ADAR1)
This study provides a new perspective for the search of ADAR1 inhibitors, and further studies on the anti-ADAR11 activity of these compounds have broad prospects.PMID:38103658 | DOI:10.1016/j.ejps.2023.106672 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 16, 2023 Category: Drugs & Pharmacology Authors: Xiaoshan Hong Zhifu Wei Lulu He Qiaowen Bu Guosong Wu Guanqiao Chen Wanshan He Qiuhua Deng Shiqi Huang Yongmei Huang Cai Yu Xiping Luo Yu Lin Source Type: research

High-throughput virtual screening to identify potential small molecule inhibitors of the Z α domain of the adenosine deaminases acting on RNA 1(ADAR1)
This study provides a new perspective for the search of ADAR1 inhibitors, and further studies on the anti-ADAR11 activity of these compounds have broad prospects.PMID:38103658 | DOI:10.1016/j.ejps.2023.106672 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 16, 2023 Category: Drugs & Pharmacology Authors: Xiaoshan Hong Zhifu Wei Lulu He Qiaowen Bu Guosong Wu Guanqiao Chen Wanshan He Qiuhua Deng Shiqi Huang Yongmei Huang Cai Yu Xiping Luo Yu Lin Source Type: research

Cyclosporine A micellar nasal spray characterization and antiviral action against SARS-CoV-2
In conclusion, this work showed that the developed cyclosporine A-loaded micellar formulations have the potential to be clinically effective against a wide spectrum of coronavirus variants.PMID:38103657 | DOI:10.1016/j.ejps.2023.106673 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 16, 2023 Category: Drugs & Pharmacology Authors: Fabiola Guareschi Elena Del Favero Caterina Ricci Laura Cant ù Martina Brandolini Vittorio Sambri Sara Nicoli Silvia Pescina Davide D'Angelo Irene Rossi Francesca Buttini Ruggero Bettini Fabio Sonvico Source Type: research

Formulation and investigation of hydrogels containing an increased level of diclofenac sodium using risk assessment tools
Eur J Pharm Sci. 2023 Dec 10;193:106666. doi: 10.1016/j.ejps.2023.106666. Online ahead of print.ABSTRACTTransdermal delivery of active ingredients is a challenge for pharmaceutical technology due to their inadequate penetration properties and the barrier function of the skin. The necessity of painless, effective, topical therapy for the aging population is growing, and a variety of diclofenac sodium-containing semi-solid preparations are available to alleviate the symptoms of these ailments. Our purpose was to formulate a novel composition with higher drug content to enhance drug release and permeation, thereby providing m...
Source: European Journal of Pharmaceutical Sciences - December 11, 2023 Category: Drugs & Pharmacology Authors: Anita Kov ács Fanni Falusi Attila G ácsi M ária Budai-Szűcs Erzs ébet Csányi Zolt án Veréb Tam ás Monostori Ildik ó Csóka Szilvia Berk ó Source Type: research

Formulation and investigation of hydrogels containing an increased level of diclofenac sodium using risk assessment tools
Eur J Pharm Sci. 2023 Dec 10;193:106666. doi: 10.1016/j.ejps.2023.106666. Online ahead of print.ABSTRACTTransdermal delivery of active ingredients is a challenge for pharmaceutical technology due to their inadequate penetration properties and the barrier function of the skin. The necessity of painless, effective, topical therapy for the aging population is growing, and a variety of diclofenac sodium-containing semi-solid preparations are available to alleviate the symptoms of these ailments. Our purpose was to formulate a novel composition with higher drug content to enhance drug release and permeation, thereby providing m...
Source: European Journal of Pharmaceutical Sciences - December 11, 2023 Category: Drugs & Pharmacology Authors: Anita Kov ács Fanni Falusi Attila G ácsi M ária Budai-Szűcs Erzs ébet Csányi Zolt án Veréb Tam ás Monostori Ildik ó Csóka Szilvia Berk ó Source Type: research

Formulation and investigation of hydrogels containing an increased level of diclofenac sodium using risk assessment tools
Eur J Pharm Sci. 2023 Dec 9:106666. doi: 10.1016/j.ejps.2023.106666. Online ahead of print.ABSTRACTTransdermal delivery of active ingredients is a challenge for pharmaceutical technology due to their inadequate penetration properties and the barrier function of the skin. The necessity of painless, effective, topical therapy for the aging population is growing, and a variety of diclofenac sodium-containing semi-solid preparations are available to alleviate the symptoms of these ailments. Our purpose was to formulate a novel composition with higher drug content to enhance drug release and permeation, thereby providing more e...
Source: European Journal of Pharmaceutical Sciences - December 11, 2023 Category: Drugs & Pharmacology Authors: Anita Kov ács Fanni Falusi Attila G ácsi M ária Budai-Szűcs Erzs ébet Csányi Zolt án Veréb Tam ás Monostori Ildik ó Csóka Szilvia Berk ó Source Type: research