European Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Recent advances and clinical translation of liposomal delivery systems in cancer therapy
We describe the recent understanding of spatiotemporal fate of liposomes in the organism after different routes of drug administration. Meanwhile, various types of liposome-based drug delivery systems that exert their respective advantages in cancer therapy while reducing side effects were discussed. Moreover, the combination of liposomal agents with other therapies (e.g. photodynamic therapy; photothermal therapy, etc.) which allows for higher tumor-targeting efficiency and therapeutic efficacy was systematically evaluated. Finally, the opportunities and challenges faced by the field of liposome nanoformulations for enter...
Source: European Journal of Pharmaceutical Sciences - January 3, 2024 Category: Drugs & Pharmacology Authors: Jiayi Chen Siyuan Hu Man Sun Jianan Shi Huan Zhang Hongmei Yu Zhaogang Yang Source Type: research

Cancer sensitizing effect of deazaflavin analogs is associated with increased intracellular drug accumulation
Eur J Pharm Sci. 2023 Dec 28:106686. doi: 10.1016/j.ejps.2023.106686. Online ahead of print.ABSTRACTAs part of our efforts geared towards developing mechanism-based cancer sensitizing agents, we have previously synthesized and characterized novel deazaflavin analogs as potent tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors for combination treatments with topoisomerase II (TOP2) poisons. Interestingly, the sensitizing effect of a few analogs toward TOP2 poison etoposide (ETP) was associated with a significant increase in intracellular drug accumulation, which could be an alternative mechanism to boost the clinical efficac...
Source: European Journal of Pharmaceutical Sciences - December 30, 2023 Category: Drugs & Pharmacology Authors: Zakia Belhadj Samuel Offei Blake A Jacobson Daniel Cambron Robert A Kratzke Zhengqiang Wang Jiashu Xie Source Type: research

Construction of chrysophanol loaded nanoparticles with N-octyl-O-sulfate chitosan for enhanced nephroprotective effect
In conclusion, the prepared chrysophanol-loaded nanoparticles potentially increased bioavailability and enhanced nephroprotective effects of chrysophanol.PMID:38154506 | DOI:10.1016/j.ejps.2023.106685 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 28, 2023 Category: Drugs & Pharmacology Authors: Qingxue Wei Fuping Gao Leiping Gao Hong Gao Jian Zhang Rui Bao Hang Zhang Jiapeng Wang Qiusheng Shen Mingjia Gu Source Type: research

A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts
CONCLUSION: Choice of dissolution apparatus can affect the dissolution/supersaturation/precipitation characteristics of pharmaceutical salts. This has to be carefully taken into account when investigating salts over different stages of pharmaceutical research and development.PMID:38154507 | DOI:10.1016/j.ejps.2023.106684 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 28, 2023 Category: Drugs & Pharmacology Authors: Laurin Z öller Alex Avdeef Eva Karlsson Anders Borde Sara Carlert Christoph Saal Jennifer Dressman Source Type: research

Formulation optimization and evaluation of oromucosal in situ gel loaded with silver nanoparticles prepared by green biosynthesis
This study offers a promising dosage form for local treatment of oral diseases.PMID:38142949 | DOI:10.1016/j.ejps.2023.106683 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 24, 2023 Category: Drugs & Pharmacology Authors: Simona Roha ľová Tom áš Wolaschka Ľudmila Balážová Katar ína Paulovičová Jana T óthová Sylvie Pavlokov á Martin Stahorsk ý Jan Gajdziok Source Type: research

Assessing the performance of new chromatographic technologies for the separation of peptide epimeric impurities: the case of Icatibant
Eur J Pharm Sci. 2023 Dec 22:106682. doi: 10.1016/j.ejps.2023.106682. Online ahead of print.ABSTRACTThe biopharmaceutical industry faces the challenge of efficiently characterising impurity profiles of therapeutical peptides, also due to their complex polar and ionisable attributes. This research explores the potential of advanced chromatographic techniques to address this challenge. The study compares dynamic electrostatic repulsion reversed phase (d-ERRP) to its counterparts (static ERRP and ion pair reversed phase IP-RP) in analysing Icatibant and its elusive epimeric impurity, [L-Arg]1-Icatibant and highlights its exce...
Source: European Journal of Pharmaceutical Sciences - December 24, 2023 Category: Drugs & Pharmacology Authors: Giulia Mazzoccanti Simone Manetto Michele Bassan Marco Macis Walter Cabri Alessia Ciogli Antonio Ricci Francesco Gasparrini Source Type: research