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Enhancing both oral bioavailability and anti-ischemic stroke efficacy of ginkgolide B by preparing nanocrystals self-stabilized Pickering nano-emulsion
This study aimed to develop GB nanocrystals (GB-NCs) and GB nanocrystals self-stabilized Pickering nano-emulsion (GB-NSSPNE) using a miniaturized wet bead milling method. Comparative evaluations were conducted in vivo and in vitro to assess their effectiveness. The findings revealed that GB-NSSPNE, with its intact nanoparticle slow release and absorption, was more effective in enhancing the oral bioavailability of GB compared to the rapid release and absorption of GB-NCs. This finding suggests a potential novel strategy for the oral delivery of GB.PMID:37871688 | DOI:10.1016/j.ejps.2023.106620 (Source: European Journal of ...
Source: European Journal of Pharmaceutical Sciences - October 23, 2023 Category: Drugs & Pharmacology Authors: Yun Liu Chungang Zhang Lan Cheng Hongxin Wang Meili Lu Hengyu Xu Source Type: research

Development Of A Thermosensitive Hydrogel Based On Polaxamer 407 And Gellan Gum With Inclusion Complexes (Sulfobutylated- β-Cyclodextrin-Farnesol) As A Local Drug Delivery System
Eur J Pharm Sci. 2023 Oct 20:106618. doi: 10.1016/j.ejps.2023.106618. Online ahead of print.ABSTRACTThis work proposes the development of a thermosensitive local drug release system based on Polaxamer 407, also known as Pluronic® F-127 (PF-127), Gellan Gum (GG) and the inclusion complex Sulfobutylated-β-cyclodextrin (CD) with Farnesol (FOH). Rheological properties of the hydrogels and their degradation were studied. According to the rheological results, a solution of 20% w/v of PF-127 forms a strong gel with a gelling temperature of about 25 °C (storage modulus of 15000 Pa). The addition of the GG increased the storage ...
Source: European Journal of Pharmaceutical Sciences - October 22, 2023 Category: Drugs & Pharmacology Authors: Inmaculada de Dios-P érez Álvaro González-Garcinuño Antonio Tabernero Marcos Blanco-L ópez Juan A Garc ía-Esteban Vidal Moreno-Rodilla Bel én Curto Patricia P érez-Esteban Eva M Mart ín Del Valle Source Type: research

Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tablets
This study investigates the influence of drug load and polymer molecular weight on the structure of tablets three-dimensionally (3D) printed from the binary mixture of prednisolone and hydroxypropyl methylcellulose (HPMC). Three different HPMC grades, (AFFINISOLTM HPMC HME 15LV, 90 Da (HPMC 15LV); 100LV, 180 Da (HPMC 100LV); 4M, 500 Da (HPMC 4M)), which are suitable for hot-melt extrusion (HME), were used in this study. HME was used to fabricate feedstock material, i.e., filaments, at the lowest possible extrusion temperature. Filaments of the three HPMC grades were prepared to contain 2.5, 5, 10 and 20 % (w/w) prednisolon...
Source: European Journal of Pharmaceutical Sciences - October 22, 2023 Category: Drugs & Pharmacology Authors: Bjarke Str øm Larsen Eric Kissi Liebert Parreiras Nogueira Natalja Genina Ingunn Tho Source Type: research