European Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

High-throughput virtual screening to identify potential small molecule inhibitors of the Z α domain of the adenosine deaminases acting on RNA 1(ADAR1)
This study provides a new perspective for the search of ADAR1 inhibitors, and further studies on the anti-ADAR11 activity of these compounds have broad prospects.PMID:38103658 | DOI:10.1016/j.ejps.2023.106672 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 16, 2023 Category: Drugs & Pharmacology Authors: Xiaoshan Hong Zhifu Wei Lulu He Qiaowen Bu Guosong Wu Guanqiao Chen Wanshan He Qiuhua Deng Shiqi Huang Yongmei Huang Cai Yu Xiping Luo Yu Lin Source Type: research

Cyclosporine A micellar nasal spray characterization and antiviral action against SARS-CoV-2
In conclusion, this work showed that the developed cyclosporine A-loaded micellar formulations have the potential to be clinically effective against a wide spectrum of coronavirus variants.PMID:38103657 | DOI:10.1016/j.ejps.2023.106673 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 16, 2023 Category: Drugs & Pharmacology Authors: Fabiola Guareschi Elena Del Favero Caterina Ricci Laura Cant ù Martina Brandolini Vittorio Sambri Sara Nicoli Silvia Pescina Davide D'Angelo Irene Rossi Francesca Buttini Ruggero Bettini Fabio Sonvico Source Type: research

Formulation and investigation of hydrogels containing an increased level of diclofenac sodium using risk assessment tools
Eur J Pharm Sci. 2023 Dec 10;193:106666. doi: 10.1016/j.ejps.2023.106666. Online ahead of print.ABSTRACTTransdermal delivery of active ingredients is a challenge for pharmaceutical technology due to their inadequate penetration properties and the barrier function of the skin. The necessity of painless, effective, topical therapy for the aging population is growing, and a variety of diclofenac sodium-containing semi-solid preparations are available to alleviate the symptoms of these ailments. Our purpose was to formulate a novel composition with higher drug content to enhance drug release and permeation, thereby providing m...
Source: European Journal of Pharmaceutical Sciences - December 11, 2023 Category: Drugs & Pharmacology Authors: Anita Kov ács Fanni Falusi Attila G ácsi M ária Budai-Szűcs Erzs ébet Csányi Zolt án Veréb Tam ás Monostori Ildik ó Csóka Szilvia Berk ó Source Type: research

Formulation and investigation of hydrogels containing an increased level of diclofenac sodium using risk assessment tools
Eur J Pharm Sci. 2023 Dec 9:106666. doi: 10.1016/j.ejps.2023.106666. Online ahead of print.ABSTRACTTransdermal delivery of active ingredients is a challenge for pharmaceutical technology due to their inadequate penetration properties and the barrier function of the skin. The necessity of painless, effective, topical therapy for the aging population is growing, and a variety of diclofenac sodium-containing semi-solid preparations are available to alleviate the symptoms of these ailments. Our purpose was to formulate a novel composition with higher drug content to enhance drug release and permeation, thereby providing more e...
Source: European Journal of Pharmaceutical Sciences - December 11, 2023 Category: Drugs & Pharmacology Authors: Anita Kov ács Fanni Falusi Attila G ácsi M ária Budai-Szűcs Erzs ébet Csányi Zolt án Veréb Tam ás Monostori Ildik ó Csóka Szilvia Berk ó Source Type: research

Population pharmacokinetics of methotrexate and 7-hydroxymethotrexate and delayed excretion in infants and young children with brain tumors
CONCLUSIONS: MTX and 7OHMTX plasma disposition were characterized for the first time in young children with brain tumors. No exposure-toxicity relationship was identified in this study, presumably due to aggressive clinical management which led to a low MTX-related toxicity rate.PMID:38070781 | DOI:10.1016/j.ejps.2023.106669 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 9, 2023 Category: Drugs & Pharmacology Authors: Olivia Campagne Jie Huang Tong Lin Wilburn E Reddick Nicholas S Selvo Arzu Onar-Thomas Deborah Ward Giles Robinson Amar Gajjar Clinton F Stewart Source Type: research

Infliximab aggregated produced in severe and mild elevated temperature stress conditions induce an extended specific CD4 T-cell response
Eur J Pharm Sci. 2023 Dec 7:106670. doi: 10.1016/j.ejps.2023.106670. Online ahead of print.ABSTRACTAggregation has been widely described as a factor contributing to therapeutic antibody immunogenicity. Although production of high-affinity anti-drug antibodies depends on the activation of CD4 T lymphocytes, little is known about the T-cell response induced by antibody aggregates, especially for aggregates produced in mild conditions resulting from minor handling errors of vials. Large insoluble infliximab (IFX) aggregates produced in severe elevated temperature stress conditions have been previously shown to induce human mo...
Source: European Journal of Pharmaceutical Sciences - December 9, 2023 Category: Drugs & Pharmacology Authors: Myriam Nabhan Sylvain Meunier Victor Le Minh Baptiste Robin Marie de Bourayne Claire Smadja Bernard Maill ère Marc Pallardy Isabelle Turbica Source Type: research

In vitro trypanocidal potency and in vivo treatment efficacy of oligomeric ethylene glycol-tethered nitrofurantoin derivatives
Eur J Pharm Sci. 2023 Dec 7;192:106668. doi: 10.1016/j.ejps.2023.106668. Online ahead of print.ABSTRACTAfrican trypanosomiasis is a significant vector-borne disease of humans and animals in the tsetse fly belt of Africa, particularly affecting production animals such as cattle, and thus, hindering food security. Trypanosoma congolense (T. congolense), the causative agent of nagana, is livestock's most virulent trypanosome species. There is currently no vaccine against trypanosomiasis; its treatment relies solely on chemotherapy. However, pathogenic resistance has been established against trypanocidal agents in clinical use...
Source: European Journal of Pharmaceutical Sciences - December 8, 2023 Category: Drugs & Pharmacology Authors: Helena D Janse van Rensburg David D N'Da Keisuke Suganuma Source Type: research

Preparation of paeoniflorin-glycyrrhizic acid complex transethosome gel and its preventive and therapeutic effects on melasma
Eur J Pharm Sci. 2023 Dec 5:106664. doi: 10.1016/j.ejps.2023.106664. Online ahead of print.ABSTRACTPaeoniflorin (PF) and glycyrrhizic acid (GL) have skin beautifying effects of anti-inflammation, anti-oxidation, inhibition of melanin formation, and reduction of skin pigmentation. To improve the transdermal permeability of PF and GL in transdermal drug delivery system (TDDS) and enhance their anti-melasma efficacy, PF-GL transethosome (PF-GL-TE) was prepared by ethanol injection method, and finally gelled with carbomer-940 to form PF-GL-TE gel. Consequently, the obtained PF-GL-TE is small and uniform, with an average partic...
Source: European Journal of Pharmaceutical Sciences - December 7, 2023 Category: Drugs & Pharmacology Authors: Yaoyao Xiao Lele Zhou Wenkang Tao Xuan Yang Junying Li Rulin Wang Yanan Zhao Can Peng Caiyun Zhang Source Type: research

Folic acid-functionalized chitosan nanoparticles with bioenzyme activity for the treatment of spinal cord injury
Eur J Pharm Sci. 2023 Dec 6;192:106667. doi: 10.1016/j.ejps.2023.106667. Online ahead of print.ABSTRACTSpinal cord injury (SCI) is a central system disease with a high rate of disability. Pathological changes such as ischemia and hypoxia of local tissues, oxidative stress and apoptosis could lead to limb pain, paralysis and even life-threatening. It was reported that catalase (CAT) was the main antioxidant in organisms, which could remove reactive oxygen species (ROS) and release oxygen (O2). However, the efficacy of the drug is largely limited due to its poor stability, low bioavailability and inability to cross the blood...
Source: European Journal of Pharmaceutical Sciences - December 7, 2023 Category: Drugs & Pharmacology Authors: Yingqiao Li Zhiru Zou Jinyu An Xiaoyao Liu Qian Wu Junpeng Sun Xiaobang Liu Jiaqun Du Ying Xiong Chao Wu Xifan Mei He Tian Source Type: research