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Three-dimensional culture model to study the biology of vacuolated notochordal cells from mouse nucleus pulposus explants
Eur Cell Mater. 2023 Mar 3;45:72-87. doi: 10.22203/eCM.v045a06.ABSTRACTIntervertebral disc degeneration (IDD) involves cellular changes in the nucleus pulposus (NP) characterised by a decline of the large vacuolated notochordal cells (vNCs) and a rise of smaller vacuole-free mature chondrocyte-like NP cells. An increasing number of studies demonstrate that notochordal cells (NCs) exert disease-modifying effects, establishing that NC-secreted factors are essential for the maintenance of a healthy intervertebral disc (IVD). However, understanding the role of the NCs is hampered by a restricted reserve of native cells and the...
Source: European Cells and Materials - March 3, 2023 Category: Cytology Authors: L Paillat K Coutant M Dutilleul S Le Lay A Camus Source Type: research