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Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects
Eur Cell Mater. 2023 Jun 29;45:158-172. doi: 10.22203/eCM.v045a11.ABSTRACTExtracellular matrix (ECM) biomaterials have shown promise for treating small artucular-joint defetcs. However, ECM-based biomaterials generally lack appropriate mechanical properties to support physiological loads and are prone to delamination in larger cartilage defects. To overcome these common mechanical limitations, a collagen hyaluronic-acid (CHyA) matrix, with proven regenerative potential, was reinforced with a bioabsorbable 3D-printed framework to support physiological loads. Polycaprolactone (PCL) was 3D-printed in two configurations, recti...
Source: European Cells and Materials - June 29, 2023 Category: Cytology Authors: M Joyce T Hodgkinson M Lemoine A Gonz ález-Vázquez D J Kelly F J O'Brien Source Type: research