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Ex vivo intervertebral disc cultures: degeneration-induction methods and their implications for clinical translation
Eur Cell Mater. 2023 Mar 29;45:88-112. doi: 10.22203/eCM.v045a07.ABSTRACTBecause low back pain is frequently a result of intervertebral disc degeneration (IVDD), strategies to regenerate or repair the IVD are currently being investigated. Often, ex vivo disc cultures of non-human IVD organs or tissue explants are used that usually do not exhibit natural IVDD. Therefore, degenerative changes mimicking those reported in human IVDD need to be induced. To support researchers in selecting ex vivo disc cultures, a systematic search was performed for them and their potential use for studying human IVDD reviewed. Five degeneration...
Source: European Cells and Materials - March 29, 2023 Category: Cytology Authors: E Salzer T C Schmitz V Hm Mouser A Vernengo B Gantenbein J U Jansen C Neidlinger-Wilke H-J Wilke S Grad C L Le Maitre M A Tryfonidou K Ito Source Type: research