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Population pharmacokinetics of esaxerenone, a novel non-steroidal mineralocorticoid receptor blocker, in patients with essential hypertension, patients with diabetic nephropathy, and healthy volunteers
CONCLUSIONS: The most influential covariates on esaxerenone exposure were coadministrations of itraconazole and rifampicin, followed by body weight. The clinical relevance of effects of renal impairment, mild to moderate hepatic impairment, and age is limited.PMID:37690271 | DOI:10.1016/j.dmpk.2023.100516 (Source: Drug Metabolism and Pharmacokinetics)
Source: Drug Metabolism and Pharmacokinetics - September 10, 2023 Category: Drugs & Pharmacology Authors: Kazutaka Yoshihara Masato Fukae Helen Kastrissios Russell Wada Takako Shimizu Hitoshi Ishizuka Source Type: research

Population pharmacokinetics of esaxerenone, a novel non-steroidal mineralocorticoid receptor blocker, in patients with essential hypertension, patients with diabetic nephropathy, and healthy volunteers
CONCLUSIONS: The most influential covariates on esaxerenone exposure were coadministrations of itraconazole and rifampicin, followed by body weight. The clinical relevance of effects of renal impairment, mild to moderate hepatic impairment, and age is limited.PMID:37690271 | DOI:10.1016/j.dmpk.2023.100516 (Source: Drug Metabolism and Pharmacokinetics)
Source: Drug Metabolism and Pharmacokinetics - September 10, 2023 Category: Drugs & Pharmacology Authors: Kazutaka Yoshihara Masato Fukae Helen Kastrissios Russell Wada Takako Shimizu Hitoshi Ishizuka Source Type: research