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Population pharmacokinetics of duloxetine in Japanese pediatric patients with major depressive disorder
The objectives of this analysis were to characterize the pharmacokinetics of duloxetine in Japanese pediatric patients aged 9-17 years with major depressive disorder (MDD) and to explore potential intrinsic factors affecting its pharmacokinetics. A population pharmacokinetic (PK) model was developed with plasma steady-state duloxetine concentrations from Japanese pediatric patients with MDD in an open-label long-term extension trial in Japan (ClinicalTrials.gov Identifier: NCT03395353). Duloxetine pharmacokinetics in Japanese pediatric patients was well described by a one-compartment model with first-order absorption. The ...
Source: Drug Metabolism and Pharmacokinetics - May 27, 2023 Category: Drugs & Pharmacology Authors: Risa Yokokawa Shibata Ryuji Kubota Kazunori Uenaka Atsunori Kaibara Toshihiro Wajima Source Type: research