Drug Metabolism and Pharmacokinetics 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.New in vitro screening system to detect drug-induced liver injury using a culture plate with low drug sorption and high oxygen permeability
Drug Metab Pharmacokinet. 2023 Apr 26;52:100511. doi: 10.1016/j.dmpk.2023.100511. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) is a major factor underlying drug withdrawal from the market. Therefore, it is important to predict DILI during the early phase of drug discovery. Metabolic activation and mitochondrial toxicity are good indicators of the potential for DILI. However, hepatocyte function, including drug-metabolizing enzyme activity and mitochondrial function, reportedly decreases under conventional culture conditions; therefore, these conditions fail to precisely detect metabolic activation and mit...
Source: Drug Metabolism and Pharmacokinetics - August 2, 2023 Category: Drugs & Pharmacology Authors: Akinori Takemura Sanae Ishii Yugo Ikeyama Katsuhiro Esashika Jun Takahashi Kousei Ito Source Type: research
