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A systematic study to evaluate the safety of ticagrelor combined with aspirin in the treatment of PCI patients in Chinese population: A single nucleotide polymorphisms study
Drug Metab Pharmacokinet. 2022 Aug 23;53:100468. doi: 10.1016/j.dmpk.2022.100468. Online ahead of print.ABSTRACTThe aim of this study was to identify genes and their associated loci related to ticagrelor pharmacokinetics and pharmacodynamics in Chinese patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). The study included 1115 patients with ACS who received a drug-eluting stent implantation between October 2019 and January 2021. Among them, 98 cases of adverse reactions were observed; thus, 97 cases without adverse reactions were selected as the comparison group. The steady-state ser...
Source: Drug Metabolism and Pharmacokinetics - November 29, 2023 Category: Drugs & Pharmacology Authors: ShaoJun Zheng YiFan Xu Qiong Jie HuiWen Mu Xing Zhang JianCheng Zhu YuBing Zhu XiJing Chen ShaoLiang Chen Source Type: research

Physiologically based pharmacokinetic (PBPK) model that describes enhanced FcRn-dependent distribution of monoclonal antibodies (mAbs) by pI-engineering in mice
Drug Metab Pharmacokinet. 2023 Mar 22;53:100506. doi: 10.1016/j.dmpk.2023.100506. Online ahead of print.ABSTRACTWe previously reported that monoclonal antibodies (mAbs) with a high isoelectric point (pI) value tended to exhibit fast plasma clearance (CL) and large steady-state volume of distribution (Vdss) in mice. However, the positive correlation between pI, CL, and Vdss cannot be described by the reported physiologically based pharmacokinetic (PBPK) models, in which FcRn-mediated transcytosis of mAbs is set to be minimal compared to convection-mediated transport. To address this issue, physiological parameters (lymph fl...
Source: Drug Metabolism and Pharmacokinetics - November 29, 2023 Category: Drugs & Pharmacology Authors: Sotaro Naoi Mizuki Yamane Takayuki Nemoto Motohiro Kato Ryoichi Saito Tatsuhiko Tachibana Source Type: research

Quantitation and characterization of glucosylsphingosine in cerebrospinal fluid (CSF), plasma, and brain of monkey model with Gaucher disease
Drug Metab Pharmacokinet. 2023 Sep 15;53:100530. doi: 10.1016/j.dmpk.2023.100530. Online ahead of print.ABSTRACTTreatment with conduritol-β-epoxide (CBE) in preclinical species is expected to be a powerful approach to generate animal models of Gaucher disease (GD) and Parkinson's disease associated with heterozygous mutations in Glucocerebrosidase (GBA-PD). However, it is not fully elucidated how quantitatively the change in glucosylsphingosine (GlcSph) levels in cerebrospinal fluid (CSF) correlates with that in the brain, which is expected to be clinically informative. Herein, we aimed to investigate the correlation with...
Source: Drug Metabolism and Pharmacokinetics - November 4, 2023 Category: Drugs & Pharmacology Authors: Sho Sato Shin-Ichi Matsumoto Yohei Kosugi Source Type: research

A model-based pharmacokinetic assessment of drug-drug interaction between tacrolimus and nirmatrelvir/ritonavir in a kidney transplant patient with COVID-19
In conclusion, nirmatrelvir/ritonavir greatly increases tacrolimus concentrations by not only reducing clearance, but also increasing bioavailability. Interactions between nirmatrelvir/ritonavir and low-bioavailability drugs which are substrates for CYP3A and P-glycoprotein, such as tacrolimus, are harmful, and concomitant use of these medicines should be avoided.PMID:37924724 | DOI:10.1016/j.dmpk.2023.100529 (Source: Drug Metabolism and Pharmacokinetics)
Source: Drug Metabolism and Pharmacokinetics - November 4, 2023 Category: Drugs & Pharmacology Authors: Takeshi Tomida Kotaro Itohara Kazuhiro Yamamoto Takeshi Kimura Kohei Fujita Atsushi Uda Yumi Kitahiro Naoki Yokoyama Yoji Hyodo Tomohiro Omura Ikuko Yano Source Type: research