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Effect of antibiotic-administration period on hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries
Drug Metab Pharmacokinet. 2023 Jun;50:100494. doi: 10.1016/j.dmpk.2023.100494. Epub 2023 Feb 9.ABSTRACTAntibiotic administration affects pharmacokinetics through changes in the intestinal microbiota, and bile acids are involved in this regulation. The purpose of the present study was to clarify the effect of different periods of antibiotic administration on the hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries. Vancomycin and polymyxin B were orally administered to mice for either 5- or 25-days. The hepatic bile acid profile of the 25-day treatment gr...
Source: Drug Metabolism and Pharmacokinetics - April 29, 2023 Category: Drugs & Pharmacology Authors: Ryotaro Yagi Takeshi Masuda Shingo Ito Sumio Ohtsuki Source Type: research