Population pharmacokinetics of esaxerenone, a novel non-steroidal mineralocorticoid receptor blocker, in patients with essential hypertension, patients with diabetic nephropathy, and healthy volunteers
CONCLUSIONS: The most influential covariates on esaxerenone exposure were coadministrations of itraconazole and rifampicin, followed by body weight. The clinical relevance of effects of renal impairment, mild to moderate hepatic impairment, and age is limited.PMID:37690271 | DOI:10.1016/j.dmpk.2023.100516
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Authors: Kazutaka Yoshihara Masato Fukae Helen Kastrissios Russell Wada Takako Shimizu Hitoshi Ishizuka Source Type: research