An integrative bioinformatics investigation and experimental validation of critically involved genes in high-grade gliomas
Lack of knowledge around underlying mechanisms of gliomas mandates intense research efforts to improve the disease outcomes. Identification of high-grade gliomas pathogenesis which is known for poor prognosis ... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - September 24, 2022 Category: Pathology Authors: Reza Ahmadi-Beni, Shirin Shahbazi and Alireza Khoshnevisan Tags: Research Source Type: research
Expression of immune checkpoint regulators, programmed death-ligand 1 (PD-L1/PD-1), cytotoxic T lymphocyte antigen 4 (CTLA-4), and indolaimine-2, 3-deoxygenase (IDO) in uterine mesenchymal tumors
Immune checkpoints including programmed death-ligand 1/programmed death-1/ (PD-L1/PD-1), cytotoxic T lymphocyte antigen 4 (CTLA-4), and indolaimine-2, 3-deoxygenase (IDO) have recently emerged as effective can... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - September 14, 2022 Category: Pathology Authors: Alireza Samiei, David W. Gjertson, Sanaz Memarzadeh, Gottfried E. Konecny and Neda A. Moatamed Tags: Research Source Type: research
Immunohistochemical staining of LEF-1 is a useful marker for distinguishing WNT-activated medulloblastomas
To investigate lymphoid enhancer factor 1 (LEF-1) protein expression in medulloblastomas (MBs) and its correlation with molecular grouping of MBs. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - September 13, 2022 Category: Pathology Authors: Depeng Wang, Jie Gong, Hui Zhang, Yulu Liu, Nannan Sun, Xiaomeng Hao and Kun Mu Tags: Research Source Type: research
Consistent expression of PD-L1 in tumor microenvironment with peripheral PD-1/PD-L1 in circulating T lymphocytes of operable breast cancer: a diagnostic test
The expression of PD-L1 in the immune microenvironment can guide the application of immunosuppressants. In order to monitor the immune status of the body, repeated biopsies have to be taken. Our research aims ... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - September 10, 2022 Category: Pathology Authors: Keyu Yuan, Jiangping Wu, Yanjie Zhao, Shuzhen Lyu, Quan Zhou, Feng Shi, Yanping Li and Qingkun Song Tags: Research Source Type: research
Papillary renal neoplasm with reverse polarity may be a novel renal cell tumor entity with low malignant potential
This study retrospectively investigated the morphological, immunohistochemical and molecular genetic features of papillary renal neoplasm with reverse polarity (PRNRP), a recently described renal tumor. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 25, 2022 Category: Pathology Authors: Tong Yang, Enhao Kang, Longxiao Zhang, Jie Zhuang, Yujun Li, Yanxia Jiang, Han Wang, Wenjuan Yu and Wei Zhang Tags: Research Source Type: research
Surveillance of Russell body inflammation of the digestive tract: a case report and review of literature
Russell body inflammation of the digestive tract (RBIDT) is a rare chronic inflammation of the digestive tract mucosa that commonly presents as Russell body gastritis (RBG). This disease is usually associated ... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 25, 2022 Category: Pathology Authors: Shuai Luo, Xiang Huang, Yao Li and Jinjing Wang Tags: Case Report Source Type: research
Clinicopathologic features of de novo non-alcoholic steatohepatitis in the post-transplant setting
Non-alcoholic steatohepatitis (NASH) has become an increasingly recognized problem in patients after orthotopic liver transplant. The aims of this study were to compare the clinicopathologic features of recurr... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 10, 2022 Category: Pathology Authors: Dana Balitzer, Jia-Huei Tsai and Ryan M. Gill Tags: Research Source Type: research
Follicular dendritic cell sarcoma of gastrointestinal tract with two emerging distinct subtypes: a case report and systemic review
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm of mesenchymal origin. FDCS of gastrointestinal tract (GI) are exceedingly uncommon. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 8, 2022 Category: Pathology Authors: Hongxing Gui, Jigisha Chaudhari and Rifat Mannan Tags: Case Report Source Type: research
Mu heavy chain disease with MYD88 L265P mutation: an unusual manifestation of lymphoplasmacytic lymphoma
Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 5, 2022 Category: Pathology Authors: Vandana Baloda, Sarah E. Wheeler, David L. Murray, Mindy C. Kohlhagen, Jeffrey A. VosUPMC, Svetlana A. Yatsenko, Mounzer E. Agha, Miroslav Djokic, Steven H. Swerdlow and Nathanael G. Bailey Tags: Case Report Source Type: research
Application of the sliding window method and Mask-RCNN method to nuclear recognition in oral cytology
We aimed to develop an artificial intelligence (AI)-assisted oral cytology method, similar to cervical cytology. We focused on the detection of cell nuclei because the ratio of cell nuclei to cytoplasm increas... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 2, 2022 Category: Pathology Authors: Eiji Mitate, Kirin Inoue, Retsushi Sato, Youichi Shimomoto, Seigo Ohba, Kinuko Ogata, Tomoya Sakai, Jun Ohno, Ikuo Yamamoto and Izumi Asahina Tags: Research Source Type: research
Association of PD-1/PD-L1 expression and Epstein- –Barr virus infection in patients with invasive breast cancer
Causative factors of breast cancer include infections, such as Epstein –Barr virus (EBV) infection. The aim of this study was to analyze the clinicopathological features of EBV-positive (IBC) and determine if E... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 16, 2022 Category: Pathology Authors: Wei-tong Zhang, Gui-lu Zhu, Wu-qin Xu, Wei Zhang, Hui-zhen Wang, Ya-bing Wang and Yong-xiang Li Tags: Research Source Type: research
Breast cancer combined with contralateral neck lymph node metastasis: a case report
Contralateral neck lymph node metastasis is rare in primary breast cancer. Its clinical staging and treatment principles lack authoritative guidelines. A case of a 30-year-old breast cancer patient with contra... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 15, 2022 Category: Pathology Authors: Xiaoxiao Zhong, Fengjiao Ding, Liyuan Qian, Wei Wu, Yanguang Wen and Boni Ding Tags: Case Report Source Type: research
Predominantly epithelial-type synovial sarcoma with overwhelming neuroendocrine differentiation: a potential diagnostic pitfall
Synovial sarcoma is an uncommon soft tissue tumor of soft tissue, characterized by a specific SS18 rearrangement. It generally manifests as a lesion composed of monomorphic spindle cells and sometimes shows va... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 11, 2022 Category: Pathology Authors: Ying Chen, Ning Zhou, Deyu Guo, Xiaodong Wang, Xin He and Yujuan Xu Tags: Case Report Source Type: research
Quantitative comparison between carotid plaque hardness and histopathological findings: an observational study
This study aimed to quantitatively compare plaque hardness with histopathological findings and identify the pathological factors ... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 11, 2022 Category: Pathology Authors: Daisuke Fukushima, Kosuke Kondo, Naoyuki Harada, Sayaka Terazono, Kei Uchino, Kazutoshi Shibuya and Nobuo Sugo Tags: Research Source Type: research
Atypical primary biliary cholangitis results in vanishing bile duct syndrome with cutaneous xanthomas: a case report
Vanishing bile duct syndrome (VBDS) is a rare but potentially severe acquired chronic cholestatic liver disease. Bile duct deficiency is a reduction of bile ducts in the liver, which can eventually lead to cho... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 4, 2022 Category: Pathology Authors: Yuebo Jia, Lin Liu, Baocheng Deng, Yu Huang, Jiaqi Zhao and Guang Bai Tags: Case Report Source Type: research
