Reconstructing virtual large slides can improve the accuracy and consistency of tumor bed evaluation for breast cancer after neoadjuvant therapy
To explore whether the “WSI Stitcher”, a program we developed for reconstructing virtual large slide through whole slide imaging fragments stitching, can improve the efficiency and consistency of pathologists ... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 28, 2022 Category: Pathology Authors: Dandan Han, Jun Liao, Meng Zhang, Chenchen Qin, Mengxue Han, Chun Wu, Jinze Li, Jianhua Yao and Yueping Liu Tags: Research Source Type: research
Cyclin D1 and PRAME expression in distinguishing melanoma in situ from benign melanocytic proliferation of the nail unit
Distinguishing benign lesion from early malignancy in melanocytic lesions of the nail unit still remains a diagnostic challenge, both clinically and histopathologically. While several immunohistochemistry (IHC... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 28, 2022 Category: Pathology Authors: Young Jae Kim, Chang Jin Jung, Hyoungmin Na, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Chan-Sik Park, Youngkyoung Lim and Chong Hyun Won Tags: Research Source Type: research
IFI16 induces inflammation in hepatitis B virus-associated glomerulonephritis by regulating the Caspase-1/ IL-1 ß pathway
IFI16 plays an important role in innate immunity against invasive microbial infection by sensing double-stranded DNA viruses due to caspase-1-dependent inflammasome activation and subsequent maturation and sec... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 23, 2022 Category: Pathology Authors: Li Liu, Shuangshuang Xie, Cheng Li, Yue Guo, Xiaoyan Liu, Xiuhua Zhao, Qiang Li and Wenjun Du Tags: Research Source Type: research
Microscopic nuclei classification, segmentation, and detection with improved deep convolutional neural networks (DCNN)
Nuclei classification, segmentation, and detection from pathological images are challenging tasks due to cellular heterogeneity in the Whole Slide Images (WSI). (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 19, 2022 Category: Pathology Authors: Zahangir Alom, Vijayan K. Asari, Anil Parwani and Tarek M. Taha Tags: Research Source Type: research
Endocrine cell micronests in an ovarian mucinous borderline tumor: a potential diagnostic pitfall for microinvasion
The occurrence of endocrine cell micronests in ovarian tumors is rarely reported. To our knowledge, there are only three prior cases reported to date: one occurring in an ovarian mucinous cystadenoma, one in a... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 14, 2022 Category: Pathology Authors: Katrina Collins, Sheila Segura and Michael Hwang Tags: Case Report Source Type: research
Diagnostic utility of antigen detection rapid diagnostic tests for Covid-19: a systematic review and meta-analysis
The early detection of coronavirus disease (COVID-19) infection to improve disease management becomes the greatest challenge. Despite the high sensitivity of RT-PCR, not only it was reported that 20 –67% of inf... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 13, 2022 Category: Pathology Authors: Somaye Ghasemi, Narges Nazari Harmooshi and Fakher Rahim Tags: Research Source Type: research
Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy
Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors. They most commonly involve the minor salivary glands of the head and neck. HCCC that occurs in uncommon locations and examining ... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - March 27, 2022 Category: Pathology Authors: Yanling Zhang, Wen Han, Jun Zhou and Xiang Yong Tags: Case Report Source Type: research
Malignant melanoma mimic fungal infection a case report
Most of malignant melanomas originate from skin and often metastasize to the lungs, rarely metastasizes to the liver and bone. However, imageology characters of lung metastasis tumor are commonly similar to th... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 27, 2022 Category: Pathology Authors: Juan Sun, Yun-Zhu Zhu, Pan-Pan Shao, Jing Ke, Wei Wang, Qiu-Lin Sun, Jia-Bin Li and Jun Cheng Tags: Case Report Source Type: research
Primary hemangioblastoma of the kidney with molecular analyses by next generation sequencing: a case report and review of the literature
Hemangioblastoma is an indolent mesenchymal tumor most frequently occurring in the central nervous system (CNS), but can also arise extraneuraxially, as part of Von Hippel-Lindau (VHL) disease or in sporadic t... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 27, 2022 Category: Pathology Authors: Xintong Wang, George K. Haines III, Meenakshi Mehrotra, Jane Houldsworth and Qiusheng Si Tags: Case Report Source Type: research
Analytical validity of DecisionDx-SCC, a gene expression profile test to identify risk of metastasis in cutaneous squamous cell carcinoma (SCC) patients
To improve identification of patients with cutaneous squamous cell carcinoma (SCC) at high risk for metastatic disease, the DecisionDx-SCC assay, a prognostic 40-gene expression profile (40-GEP) test, was deve... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 25, 2022 Category: Pathology Authors: Sherri Borman, Jeff Wilkinson, Lauren Meldi-Sholl, Clare Johnson, Kelsey Carter, Kyle R. Covington, Alison L. Fitzgerald, Sarah J. Kurley, Aaron S. Farberg, Matthew S. Goldberg, Federico A. Monzon, Kristen Oelschlager and Robert W. Cook Tags: Research Source Type: research
Morphologically, immunohistochemically and PCR proven lymphocytic viral peri-, endo-, myocarditis in patients with fatal COVID-19
Despite a reported cardiac injury in patients with new coronavirus infection, the possibility and specifics of genuine viral myocarditis in COVID-19 remains not fully clear. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 17, 2022 Category: Pathology Authors: Evgeniya Kogan, Yuriy Berezovskiy, Olga Blagova, Anna Kukleva, Lyudmila Semyonova, Evgeniy Gretsov and Atadzhan Ergeshov Tags: Short report Source Type: research
Genetic mutation profiles and immune microenvironment analysis of pulmonary enteric adenocarcinoma
Pulmonary enteric adenocarcinoma (PEAC) has distinctive clinical outcomes, radiographic, pathological and molecular characteristics. The prognosis of patients with PEAC was poor. However, molecular profiles an... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 16, 2022 Category: Pathology Authors: Min Xie, Dong Chen, Yong Li, Xiansheng Liu, Dong Kuang and Xiaochen Li Tags: Research Source Type: research
Thorahcic SMARCA4-deficient undifferentiated tumors with ganglioneuroma and enchondroma: implications for SLC7A11 and ARID1A expression: a case report
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4-deficient thoracic sarcoma (SMARCA4-DTS) is a rare disease that has recently been described as an entity. It is... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 12, 2022 Category: Pathology Authors: Yusuke Kito, Keisuke Kawashima, Chiemi Saigo, Masayoshi Hasegawa, Shusuke Nomura, Takuya Mikamo, Yuki Hanamatsu, Yasuhiro Matsuo and Tamostu Takeuchi Tags: Case Report Source Type: research
Lipid metabolism contribute to the pathogenesis of IgA Vasculitis
The underlying mechanism of IgA vasculitis (IgAV) and IgA vasculitis with nephritis (IgAVN) remains unclear. Therefore, there are no accurate diagnostic methods. Lipid metabolism is related to many immune rela... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 11, 2022 Category: Pathology Authors: Ying Liu, Min Wen, Qingnan He, Xiqiang Dang, Shipin Feng, Taohua Liu, Xuewei Ding, Xiaoyan Li and Xiaojie He Tags: Research Source Type: research
Coexistence of carcinoid tumor and adenocarcinoma of the lung; morphological, immunohistochemical and genetic analyses, a case report
Pulmonary carcinoid tumors rarely coexist with non-small cell lung carcinoma, and only nine cases have been reported previously. The pathogenesis and origin of these combined tumors remain unclear because of i... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 10, 2022 Category: Pathology Authors: Chihiro Inoue, Sachiko Konosu-Fukaya, Kazuhiro Murakami, Ryoko Saito-Koyama, Hirofumi Watanabe, Hideki Mitomo, Naoya Ishibashi, Takafumi Sugawara, Toshiharu Tabata, Hironobu Sasano and Yasuhiro Nakamura Tags: Case Report Source Type: research
