New Diagnostic Tools to Evaluate Hair Loss
The precise and reliable diagnosis of hair loss disorders is essential for developing a successful management plan. It is, thus, the responsibility of the dermatologist to select the appropriate diagnostic tools to effectively evaluate patients presenting with hair loss concerns. Fortunately, there is a growing body of noninvasive and invasive diagnostic resources, each with advantages and disadvantages. For the practicing dermatologist, tactile assessments and direct visualization are enhanced with scoring instruments, questionnaires, handheld trichoscopy, and scalp biopsy. For research and clinical study purposes, the mo...
Source: Dermatologic Clinics - May 15, 2021 Category: Dermatology Authors: Alana Kurtti, Jared Jagdeo, Amanda Eisinger, Kumar Sukhdeo Source Type: research
Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA) is the most common form of primary scarring alopecia diagnosed in women of African descent. Although the etiology was originally attributed exclusively to hairstyling practices common among women of African descent, more recent research on CCCA supports the concept that there are several contributing factors, including variants in gene expression, hair grooming practices that increase fragility on the hair follicle, and associations with other systemic conditions. Treatment of CCCA involves a combination of patient counseling and education on alternative hairstyles, medical t...
Source: Dermatologic Clinics - May 15, 2021 Category: Dermatology Authors: Christina N. Lawson, Awa Bakayoko, Valerie D. Callender Source Type: research
Alopecia Areata
Alopecia areata (AA) is a chronic, relapsing, autoimmune disorder characterized by patchy nonscaring hair loss. Although the pathogenesis of alopecia areata is not yet completely elucidated, loss of immune privilege in anagen stage hair follicles is widely accepted to play a key role. Several cytokines that depend on Janus kinase signaling have been identified to be involved in AA, including interleukin (IL)-2, IL-7, IL-15, IL-21, and interferon- γ, making Janus kinase inhibitors an attractive therapeutic target. Available information indicates that about 70% of patients with AA experience significant regrowth, but interr...
Source: Dermatologic Clinics - May 15, 2021 Category: Dermatology Authors: Caiwei Zheng, Antonella Tosti Source Type: research
Platelet-rich Plasma and Cell Therapy
Current medicinal therapies for treating hair loss have shortcomes due to variability and ineffectiveness, noncompliance, and adverse effects. The prevalence of hair loss and its associated negative psychological impact have driven research into regenerative medicine approaches, such as platelet-rich plasma (PRP) and cell-based therapies, in an attempt to find alternative, safe, effective, and reproducible treatments. Current research shows promising results from these therapies; however, more robust trials are needed to confirm the reported efficacies of PRP and cell-based therapies. Moreover, standardization of treatment...
Source: Dermatologic Clinics - May 15, 2021 Category: Dermatology Authors: Aditya K. Gupta, Helen J. Renaud, Jeffrey A. Rapaport Source Type: research
Combination Approaches for Combatting Hair Loss
Significant androgenetic hair loss occurs in men older than 50 years, and in women it occurs in many who are perimenopausal, menopausal, and postmenopausal. By age 60 years, it is estimated that 80% of women experience hair loss. Other nonandrogenetic forms of hair loss occur due to various dermatologic disorders as well as systemic disorders. Children may also experience significant hair loss, often due to genetic abnormalities and incidences of trauma. In this article the author discusses a combination approach to hair loss for men, women, and children. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - May 15, 2021 Category: Dermatology Authors: Paul T. Rose Source Type: research
The Hair Comeback
Once a condition thought to happen to men only, hair loss is now widely recognized that it affects people of all ages, genders, and ethnicities with no exceptions. Compared with other dermatologic problems, losing hair carries a lot larger emotional overtone in affected individuals. In this age of innovation, however, with a deep understanding of the causes of hair loss together with advances in diagnostic tools, and a tech revolution in energy-based devices for hair growth and automated hair transplantation, the reversal of hair loss can be a reality. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - May 13, 2021 Category: Dermatology Authors: Neil S. Sadick Tags: Preface Source Type: research
Nutraceuticals
Hair loss has a multifactorial etiology that includes internal and external triggers. These include poor diet and nutrition (extrinsic), as well as the natural aging process (intrinsic). Other external factors include pollution, hair products, hair styling, and ultraviolet exposure, which can cause free radical formation, oxidative stress, and microinflammation at the site of the hair follicles. Botanic substances have demonstrated antioxidant, anti-inflammatory, and immune-enhancing properties. Vitamins and minerals are needed when deficiencies are apparent or demonstrate efficacy at higher doses than normally found in on...
Source: Dermatologic Clinics - May 12, 2021 Category: Dermatology Authors: Glynis Ablon Source Type: research
Nail Tumors
This article describes nail tumors and their clinical features, biologic behavior, and treatment. Tumors included are onychopapilloma, onychomatricoma, periungual fibromas/fibrokeratomas, glomus tumors, subungual exostosis, myxoid cysts, and squamous cell carcinoma. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - March 19, 2021 Category: Dermatology Authors: Anna Quinn Hare, Phoebe Rich Source Type: research
Pathology of the Nail Unit
This article discusses the histologic findings in key nail unit diseases, including inflammatory, infectious, and neoplastic conditions. The emphasis is on clinicopathologic correlates, best practices to demonstrate the relevant histopathologic features, and pitfalls in diagnosis. Understanding the pathology of these disorders enhances clinical acumen and may affect the choice of biopsy procedures and treatment measures, with the outcome of better clinical care for patients with nail disease. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - March 19, 2021 Category: Dermatology Authors: Beth S. Ruben Source Type: research
Concepts, Role, and Advances on Nail Imaging
This review discusses, from a practical point of view, the most common imaging techniques and their applications in nail pathologies with some technical considerations. There are several imaging techniques for studying the nail, and all of them require proper devices and trained operators. The highest axial resolution and a more extensive range of applications are provided by ultrasound, which currently is the first-choice imaging technique for evaluating nail conditions. A correlation of state-of-the-art clinical and imaging figures supports the review of this topic. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - March 19, 2021 Category: Dermatology Authors: Ximena Wortsman Source Type: research
Nail is Systemic Disorders: Main Signs and Clues
Describing and listing all nail symptoms and signs in systemic disorders has already been widely detailed in dedicated textbooks. To be tutorial, this article described most common nails signs and the systemic disorders one may encounter in routine dermatologic consultation. Capsule summaries are presented for each section. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - March 19, 2021 Category: Dermatology Authors: Florence Dehavay, Bertrand Richert Source Type: research
Nail Cosmetics and Adornment
Nail polish is a nitrocellulose-based film that is modified to create a plastic shiny colored film that can be painted on the nail plate. The desire to develop a long-lasting pigmented film has resulted in the development of nail shellacs based on polymethyl methacrylate (PMMA) designed to polymerize on the nail plate. These films are chip resistant and long wearing, designed to last 3 to 4 weeks. Further polymer use has resulted in the ability to sculpt an elongated nail on the nail plate to create the appearance of long nails. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - March 19, 2021 Category: Dermatology Authors: Zoe Diana Draelos Source Type: research
Nail Disorders: Diagnosis and Management
Nail conditions are commonly seen in dermatologic practice with significant impact on quality of life. The purpose of this issue of Dermatologic Clinics, authored by international nail experts in the field, is to provide an update on diagnosis and treatment of nail disease. Medical and surgical residency training in nail disease may be quite variable depending on incorporation of nail lectures into didactics, hands-on surgical training sessions, and the presence of a dermatologist that specializes in nail disease on the faculty. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - March 19, 2021 Category: Dermatology Authors: Shari R. Lipner Tags: Preface Source Type: research
Nail Disorders: Diagnosis and Management
DERMATOLOGIC CLINICS (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - March 19, 2021 Category: Dermatology Authors: Shari R. Lipner Source Type: research
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ELSEVIER (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - March 19, 2021 Category: Dermatology Source Type: research
