From Histiocytoid Sweet Syndrome to Myelodysplasia Cutis
In 2005, a new histologic variant of Sweet syndrome (SS) has been described and termed histiocytoid SS (HSS). Clinically, patients had a typical SS, but on skin biopsy, the infiltrates were composed of immature nonblast myeloid cells. Nearly 50% of patients with HSS have myelodysplastic syndrome (MDS). HSS may be the first manifestation leading to the diagnosis of MDS. In 2015, a new category of myeloid dermatosis has been proposed, called myelodysplasia cutis, describing the specific skin infiltration by myelodysplastic cells in patients with MDS. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 11, 2023 Category: Dermatology Authors: Marie-Dominique Vignon-Pennamen, Maxime Battistella Source Type: research
Sweet Syndrome and Neutrophilic Dermatosis of the Dorsal Hands
Sweet syndrome is a rare cutaneous condition with a broad clinical differential diagnosis. It can be classified into 3 subtypes: classic, malignancy-associated, and drug-induced. There are numerous associated disorders and provoking medications. Uncommonly, it can present as a multiorgan disease and cause significant morbidity. Systemic corticosteroids are the gold standard of treatment and yield rapid improvements in both lesions and symptoms. Nonsteroidal therapies may be effective alternatives, although high-quality comparative data are lacking. Some treatments for Sweet syndrome have paradoxically been implicated in th...
Source: Dermatologic Clinics - September 9, 2023 Category: Dermatology Authors: Matthew L. Hrin, William W. Huang Source Type: research
Palisaded Neutrophilic Granulomatous Dermatitis, Bowel-Associated Dermatosis –Arthritis Syndrome, and Rheumatoid Neutrophilic Dermatitis
Neutrophilic dermatosis is a heterogeneous group of inflammatory skin diseases characterized by the presence of a sterile neutrophilic infiltrate on histopathology. Three specific types of neutrophilic dermatoses are reviewed in this article: palisaded neutrophilic granulomatous dermatitis, bowel-associated dermatosis –arthritis syndrome, and rheumatoid neutrophilic dermatitis. The authors review the literature and highlight the clinical and histopathological features, disease pathogenesis, and the association of these conditions with various systemic diseases such as rheumatoid arthritis, inflammatory bowel di sease, an...
Source: Dermatologic Clinics - September 9, 2023 Category: Dermatology Authors: Mika Yamanaka-Takaichi, Afsaneh Alavi Source Type: research
Clinical Assessment, Diagnosis, and Management of Infraorbital Wrinkles and Pigmentation
Lower eyelid skin is unique and different from that of other areas. In addition to being an area of high exposure to the sun and elements, there are anatomic considerations and specific histologic characteristics that can cause the skin in this area to be more sensitive. These attributes can readily cause under-eye wrinkling and pigmentation. This review aims to present an updated overview of the current knowledge regarding the clinical characteristics, diagnosis, and management of wrinkles and pigmentation in this area. These disorders are usually caused by different factors, such as genetics, aging, sun exposure, lack of...
Source: Dermatologic Clinics - September 7, 2023 Category: Dermatology Authors: Gyanesh Rathore, Kinnor Das, Marina Landau, Ines Verner, Martin Kassir, Hassan Galadari, Michael H. Gold, Mahsa Babaei, Mohamad Goldust Source Type: research
Pyoderma Gangrenosum
Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis with variable clinical features. The classic presentation is an ulceration with an erythematous to violaceous undermined border. Extracutaneous manifestations may occur. Associated systemic diseases include inflammatory bowel disease, inflammatory arthritides, and hematologic disorders. The pathophysiologic mechanism of disease is not completely known but likely related to the cumulative impact of inflammation, immune-mediated neutrophilic dysfunction, and genetic predisposition. Incidence is between 3 and 10 people per million but may be greater due to u...
Source: Dermatologic Clinics - September 7, 2023 Category: Dermatology Authors: Mallory L. Zaino, Courtney R. Schadt, Jeffrey P. Callen, Lafayette G. Owen Source Type: research
Superficial and Bullous Neutrophilic Dermatoses
Sneddon –Wilkinson disease (SWD), IgA pemphigus, and bullous systemic lupus erythematosus (BSLE) are superficial and bullous neutrophilic dermatoses. They are all characterized by sterile neutrophilic infiltrate but differ in the level of skin affected and presence of autoantibodies. Both SWD and IgA pemp higus present with grouped flaccid pustules and have epidermal involvement; it is unclear whether they are distinct or exist on a spectrum of the same disease. IgA pemphigus is distinguished from SWD by positive direct immunofluorescence showing intercellular IgA deposition. BSLE presents with tense bullae, dermal neutr...
Source: Dermatologic Clinics - September 7, 2023 Category: Dermatology Authors: Priya Manjaly, Katherine Sanchez, Samantha Gregoire, Sophia Ly, Kanika Kamal, Arash Mostaghimi Source Type: research
Revisiting the Ligament Line of the Face
This article proposes a new understanding of the ligament. To address this concept, the authors entitled this line the functional ligament line. This article links facial anatomy and its changes during movements to the injectable fillers according to their mechanism of action and rheologic properties. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - August 30, 2023 Category: Dermatology Authors: Andre Braz, Eliandre Palermo, Maria Claudia Issa Source Type: research
Cosmetic Experiences from Across the Globe
The pursuit of beauty is as old as humanity itself. Over the centuries, cultures around the world have developed diverse beauty rituals and skincare techniques, each reflecting their unique values and traditions. The world of cosmetic dermatology has been expanding exponentially. This expansion was helped by the intricate ability of the world to connect. The ease by which practitioners from across the globe can share their knowledge and experiences in a scientific medium, through publications as well as congress presentations, has been paramount in making cosmetic procedures safe and accessible. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - August 23, 2023 Category: Dermatology Authors: Hassan I. Galadari Tags: Preface Source Type: research
How to Be a Successful Businesswoman in Dermatology
Successful businesswomen in dermatology know what type of practice they want and create a plan to make it happen. They align their business with their life and surround themselves with people who support their goals. They accept support but know how to delegate. They do the hard work required to be successful, gaining knowledge and strength from the experience. When they make mistakes, they learn from them. They try to make the most of each patient's experience, while acknowledging that relationships with family, friends, and colleagues, as well as personal growth, are of utmost significance outside of their practices. (So...
Source: Dermatologic Clinics - August 11, 2023 Category: Dermatology Authors: Cyndi Yag-Howard Source Type: research
Is Private Practice a Possibility for Me?
Whether you are coming out of residency or considering your options as you transition from one job to another, the option of private practice (solo or group) may have crossed your mind. This collection of essays should inform and perhaps inspire you to consider private practice. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - August 11, 2023 Category: Dermatology Authors: Brett Coldiron Tags: Preface Source Type: research
The Needle Versus Cannula Debate in Soft Tissue Augmentation
In recent years, injectables have become increasingly popular in cosmetic procedures. The choice between using a needle or a cannula depends on several factors, including the site of injection, the filler type, the patient ’s preferences, and the practitioner’s skills. Although needles are easy to use, cost-effective, and best for treating superficial rhytids, they may cause tissue injury. Cannulas are safer, particularly when injecting deep to the bone, and can provide more even distribution of filler material wh en filling large zones. An in-depth understanding of the facial anatomy and ongoing training are crucial f...
Source: Dermatologic Clinics - August 1, 2023 Category: Dermatology Authors: Jana Al-Hage, Hassan Galadari Source Type: research
Achieving the Attractive Asian Midface Profile with Hyaluronic Acid –Based Fillers
Despite different ethnic origins among Asians, midface enhancement is the most frequent noninvasive procedure for hyaluronic acid injection either as a stand-alone treatment or as part of the pan-facial beautification strategy. Because Asians often have an aesthetically undesirable wide, flat, and short face, improving the projection of midface and midline facial structures is an indispensable aesthetic procedure in creating a smaller facial appearance with better three-dimensionality. Achieving an oval facial shape together with increased facial height is also required in most circumstances for a natural and balanced resu...
Source: Dermatologic Clinics - August 1, 2023 Category: Dermatology Authors: Wilson W.S. Ho Source Type: research
Hacking the International Nomenclature of Cosmetic Ingredients List- How to Read Ingredients in Cosmetic Products and What Is Important for a Dermatologist to Know?
Skin specialists and practitioners are commonly requested to recommend on cosmetic products to improve skin appearance and address certain “non-medical” concerns. During residency and further education, dermatologists rarely expand their knowledge regarding cosmetic ingredients, except if they are a cause of medical condition or disease, such as contact dermatitis. This review provides guidelines to the INCI list structure, togethe r with basic principles of cosmetic products formulation. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - July 27, 2023 Category: Dermatology Authors: Marina Landau, Shir Blum Landau Source Type: research
Facial Overfilled Syndrome
Facial overfilled syndrome is an underdiagnosed aesthetic complication due to multiple incorrect placements of fillers. Facial distortion due to the overfilled syndrome can be exaggerated by facial expressions and movements and worsens with tissue ptosis due to aging. Commonly “produced” by practitioners depending solely on fillers as a single modality for treatment, the overfilled syndrome can be seen among those who had volume overload in the midface, forehead, chin, and nose. Incorrectly placed dermal fillers, poor selection of filler products, overzealous attempts by the injectors, and overly enthusiastic clients w...
Source: Dermatologic Clinics - July 26, 2023 Category: Dermatology Authors: Tingsong Lim Source Type: research
Cellulite
is a common cosmetic concern among postpubertal women. Despite its high prevalence, there have been only a few high-quality studies assessing its exact prevalence, risk factors, and pathophysiologic mechanisms. It has been difficult to achieve long-lasting results with the available treatments, including topical agents, energy-based devices, subcision, and injectables. In this review, the authors summarize the proposed etiologic factors, grading scales, and treatment options. Further well-designed studies are essential to improve our knowledge of the condition and lead to improved treatment strategies. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - July 26, 2023 Category: Dermatology Authors: Samar Khalil, Hassan Galadari Source Type: research
