Genetic Causes of Vascular Malformations and Common Signaling Pathways Involved in Their Formation
The identification of the genetic cause of vascular malformations is improving understanding of pathogenesis of these lesions and also informing potential opportunities for treatment. Somatic activating mutations affecting RAS/MAPK and PIK3/AKT/mTor pathways are implicated in all types of vascular malformations. Pathogenic variants associated with vascular lesions may be germline or somatic. Next-generation sequencing technologies allow identification of lower level mosaic mutations than was achievable with standard Sanger sequencing. Best practice strategies to identify underlying genetic mutations in vascular malformatio...
Source: Dermatologic Clinics - October 1, 2022 Category: Dermatology Authors: Aubrey L. Rose, Sara S. Cathey Source Type: research
Vascular Anomalies
DERMATOLOGIC CLINICS (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - October 1, 2022 Category: Dermatology Authors: Marcelo Hochman, Lara Wine Lee Source Type: research
Copyright
ELSEVIER (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - October 1, 2022 Category: Dermatology Source Type: research
Contributors
BRUCE H. THIERS, MD (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - October 1, 2022 Category: Dermatology Source Type: research
Contents
Marcelo Hochman and Lara Wine Lee (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - October 1, 2022 Category: Dermatology Source Type: research
Forthcoming Issues
Cutaneous Oncology Update (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - October 1, 2022 Category: Dermatology Source Type: research
Venous Malformations
Venous malformations are the most common congenital vascular malformations. Because venous malformations can be complex, difficult to treat, and associated with late complications, it is important to know the basics of the different types of venous malformations and clinical differential diagnosis. Patients with complex lesions may be best served by a specialty vascular anomalies clinic. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 18, 2022 Category: Dermatology Authors: Maria Gnarra Buethe, Susan J. Bayliss, Leonid Shmuylovich Source Type: research
Laser Treatment of Vascular Anomalies
Lasers are a safe and effective tool for the treatment of vascular anomalies. There are many laser options available. Matching laser parameters with the characteristics of the vasculature in these lesions can selectively deliver energy to the abnormal tissue. This can lead to reduction in size and symptoms of vascular malformations and hemangiomas. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 18, 2022 Category: Dermatology Authors: Austin N. DeHart, Gresham T. Richter Source Type: research
Timing and Rationale of Treatment
Various clinical disciplines defend the modality of therapy available to them (eg, medical vs surgery) when, in fact, multi-modality therapy is usually in the best interest of the patient. The aim of any modality of treatment is to obtain the best possible result for a given patient. To successfully achieve that aim for infantile hemangiomas (IH) and all vascular anomalies, defining what is meant by the best possible result and by when to achieve that, the result needs to be defined. Perhaps more important is to make a determination of what is an acceptable result. The impact of a 1-cm IH of the nasal tip is different from...
Source: Dermatologic Clinics - September 18, 2022 Category: Dermatology Authors: Marcelo Hochman Source Type: research
Infantile Hemangiomas
Infantile hemangiomas (IHs) are the most common benign vascular tumors of childhood. They develop during the first few weeks of life and naturally progress by proliferating over several months before they involute and resolve; this renders them inconsequential in many cases, but sometimes IHs can have detrimental consequences on function and disfigurement. Hence, systemic propranolol has become a crucial element in IH management, alongside various other medical, procedural, and surgical options that aim to promote their quicker resolution and prevent and alleviate complications. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 18, 2022 Category: Dermatology Authors: Divina Justina Hasbani, Lamiaa Hamie Source Type: research
Capillary Malformations
This article can aid clinicians in better identifying CMs and associated syndromes and provide consistent terminology to facilitate interdisciplinary management. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 18, 2022 Category: Dermatology Authors: Karla Escobar, Karan Pandher, Marla N. Jahnke Source Type: research
Surgical Treatment of Vascular Anomalies
Recommendation for the surgical approach to vascular anomalies is rapidly evolving. From an isolated approach, surgery is best seen nowadays as an adjunctive tool in multidisciplinary management. Several studies focusing on targeted therapy based on genetic findings were published, and their use in clinical practice is on the way. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 18, 2022 Category: Dermatology Authors: Dov Charles Goldenberg, Rafael Ferreira Zatz Source Type: research
Histopathology of Vascular Malformations
This article follows the published classification of the International Society for the Study of Vascular Anomalies. It describes characteristic histopathologic findings in tissues of vascular malformations and information on known genetic causes. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 18, 2022 Category: Dermatology Authors: Thuy L. Phung Source Type: research
Histopathology of Vascular Tumors
This article follows the published classification of the International Society for the Study of Vascular Anomalies. It describes characteristic histopathologic findings in vascular tumors and information on known genetic causes. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 18, 2022 Category: Dermatology Authors: Thuy L. Phung Source Type: research
Vascular Anomalies
This article provides a brief, yet comprehensive overview of all cutaneous vascular tumors currently recognized by the ISSVA, including presentation, diagnosis, and treatment. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 18, 2022 Category: Dermatology Authors: Kelly Atherton, Harriet Hinen Source Type: research
