The Utility of the Mini-Addenbrooke ’s Cognitive Examination as a Screen for Cognitive Impairment in Elderly Patients with Chronic Kidney Disease and Diabetes

Conclusion: The M-ACE is an easily administered test with good sensitivity and specificity to capture and assist in the diagnosis of MCI or dementia in patients with CKD and diabetes. 
Dement Geriatr Cogn Disord Extra 2016;6:541 –548 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - December 6, 2016 Category: Geriatrics Source Type: research

Predictive Factors of Rapid Cognitive Decline in Patients with Alzheimer Disease 

Conclusion: Early detection of the RCD risk in AD patients could make it possible to anticipate the patient ’s medical needs and adjust the care plan for caregiver burden.
Dement Geriatr Cogn Disord Extra 2016;6:549 –558 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - December 6, 2016 Category: Geriatrics Source Type: research

Magnetic Resonance Volumetry: Prediction of Subjective Memory Complaints and Mild Cognitive Impairment, and Associations with Genetic and Cardiovascular Risk Factors
Conclusions: Fully automated MR volumetry can distinguish subjects with SMC and MCI from controls in a general population, but insuf ficiently to assume a clear clinical role. Research on sporadic LOAD might benefit from a sex-specific search for genetic risk factors.Dement Geriatr Cogn Disord Extra 2016;6:529 –541 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - November 25, 2016 Category: Geriatrics Source Type: research

Donepezil Enhances Frontal Functional Connectivity in Alzheimer's Disease: A Pilot Study
Conclusion: This ‘proof of concept' study suggests that changes in network-specific FC might be a biomarker of pharmacological intervention efficacy in AD.Dement Geriatr Cogn Disord Extra 2016;6:518-528 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - October 21, 2016 Category: Geriatrics Source Type: research

Dance Experience and Associations with Cortical Gray Matter Thickness in the Aging Population
Discussion: Together, these results suggest that dance may result in an enhancement of cognitive reserve in aging, which may help avert or delay MCI.Dement Geriatr Cogn Disord Extra 2016;6:508-517 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - October 20, 2016 Category: Geriatrics Source Type: research

Cognitive Decline in Patients with Chronic Hydrocephalus and Normal Aging: ‘Growing into Deficits'?
Conclusion: In our opinion, the theory of ‘growing into deficits' shows a parallel with the clinical course of CH and normal aging when Alzheimer's disease was considered very unlikely, because most of these patients were functioning well for a very large part of their lives. The altered cerebrospinal fluid dynamics might make the brain m ore vulnerable to aging-related changes, leading to a faster cognitive decline in CH patients compared to healthy subjects, especially in case of concomitant brain damage such as traumatic brain injury or meningitis.Dement Geriatr Cogn Disord Extra 2016;6:500-507 (Source: Dementia and G...
Source: Dementia and Geriatric Cognitive Disorders Extra - October 11, 2016 Category: Geriatrics Source Type: research

Hippocampal Volumetry as a Biomarker for Dementia in People with Low Education
Background/Aims: To evaluate the relationship between hippocampal volume and cognitive decline in patients with dementia due to probable Alzheimer's disease (AD), amnestic mild cognitive impairment (aMCI) and education, and the possible relationship between cognitive reserve and education in this population.Methods: From February 2013 to October 2015, 76 patients (25 men, 51 women) were classified according to the NIA-AA diagnostic criteria. We used two 3.0-tesla MRI scanners and performed manual hippocampal volumetry.Results: Twenty-six patients were found to have AD, 20 aMCI and 30 had normal aging (NA). The mean normali...
Source: Dementia and Geriatric Cognitive Disorders Extra - October 11, 2016 Category: Geriatrics Source Type: research

Long-Term Survival of Patients Receiving Artificial Nutrition in Japanese Psychiatric Hospitals
Conclusion: Patients with mental disorders survived longer than those with dementia diseases on artificial nutrition. A PEG tube and good nutrition seem to be important for long-term survival.Dement Geriatr Cogn Disord Extra 2016;6:477-485 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - October 6, 2016 Category: Geriatrics Source Type: research

Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting?
Conclusion: AD biomarkers - in particular the A β42/p-tau ratio, but not neuroinflammatory parameters - predicted clinical progression, regardless of etiology.Dement Geriatr Cogn Disord Extra 2016;6:465-476 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - October 6, 2016 Category: Geriatrics Source Type: research

Detection of Low-Signal Pulvinar Areas Using Diffusion-Weighted Imaging in Patients with Dementia Experiencing Visual Hallucinations
Conclusions: The results of the present study indicate that diffusion-weighted 3T MRI is the most suitable method for the detection of pulvinar nuclei in patients with dementia experiencing visual hallucinations.Dement Geriatr Cogn Disord Extra 2016;6:458-464 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - September 28, 2016 Category: Geriatrics Source Type: research

The Effect of Spinal Tap Test on Different Sensory Modalities of Postural Stability in Idiopathic Normal Pressure Hydrocephalus
Background/Aims: Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients.Methods: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test.Results: The gait score showed a significant improvement 24 h after spinal tap test in all subtests and in the sum score ...
Source: Dementia and Geriatric Cognitive Disorders Extra - September 26, 2016 Category: Geriatrics Source Type: research

Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia
Conclusion: There are nfPPA patients with imaging-supported diagnosis and preserved motor speech skills who do not exhibit frank agrammatism, and this may persist beyond the earliest stages of the illness. Because absence of frank agrammatism is a subsidiary diagnostic feature in the logopenic variant of PPA, this result has implications for differentiation of the nonfluent and logopenic variants, and indicates that PPA patients with nonfluent speech in the absence of frank agrammatism or AOS do not necessarily have the logopenic variant.Dement Geriatr Cogn Disord Extra 2016;6:407-423 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - September 22, 2016 Category: Geriatrics Source Type: research

The Effects of Donepezil on 15-Item Geriatric Depression Scale Structure in Patients with Alzheimer Disease
Conclusions: These results suggest that the GDS15 may be comprised of a heterogeneous scale and donepezil differentially affects the GDS15 subgroup in AD.Dement Geriatr Cogn Disord Extra 2016;6:437-446 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - September 22, 2016 Category: Geriatrics Source Type: research

Improved Necker Cube Drawing-Based Assessment Battery for Constructional Apraxia: The Mie Constructional Apraxia Scale (MCAS)
Conclusions: We conclude that the MCAS, which includes both the assessment of the drawn Necker cube shape and the drawing process, is useful for detecting even mild CA.Dement Geriatr Cogn Disord Extra 2016;6:424-436 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - September 22, 2016 Category: Geriatrics Source Type: research

Clinical Recommendations for the Use of Donepezil 23 mg in Moderate-to-Severe Alzheimer's Disease in the Asia-Pacific Region
Background: The ‘Asia-Pacific Expert Panel (APEX) for donepezil 23 mg' met in November 2015 to review evidence for the recently approved high dose of donepezil and to provide recommendations to help physicians in Asia make informed clinical decisions about using donepezil 23 mg in patients with moderate-to-severe Alzheimer's disease (AD).Summary: In a global phase III study (study 326) in patients with moderate-to-severe AD, donepezil 23 mg/day demonstrated significantly greater cognitive benefits versus donepezil 10 mg/day, with a between-treatment difference in mean change in the Severe Impairment Battery score of 2.2 ...
Source: Dementia and Geriatric Cognitive Disorders Extra - September 12, 2016 Category: Geriatrics Source Type: research