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Multi-Infarct Dementia: A Historical Perspective
Background: Multi-infarct dementia (MID), a prominent subtype of vascular dementia (VaD), has only achieved recognition in the last 4 decades. Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate.Summary: This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges. This paper follows the first descriptive decade, a shift to a preventati...
Source: Dementia and Geriatric Cognitive Disorders Extra - May 4, 2017 Category: Geriatrics Source Type: research

Early- versus Late-Onset Alzheimer Disease: Long-Term Functional Outcomes, Nursing Home Placement, and Risk Factors for Rate of Progression
Conclusion: This study highlights the clinical importance of an earlier diagnosis and treatment initiation and the need for functional evaluations in EOAD. Despite the age differences between EOAD and LOAD, a similar need for nursing homes was observed.Dement Geriatr Cogn Disord Extra 2017;7:172 –187 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - May 4, 2017 Category: Geriatrics Source Type: research

Associations between Pain and Quality of Life in Severe Dementia: A Norwegian Cross-Sectional Study
Conclusion: Pain, neuropsychiatric symptoms, and depressive symptoms appear to be important factors that influence the quality of life for nursing home residents with severe dementia. Therefore, multidimensional interventions may be beneficial for maintaining or improving quality of life in this population.Dement Geriatr Cogn Disord Extra 2017;7:109 –121 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - April 11, 2017 Category: Geriatrics Source Type: research

Effect of the Sonas Programme on Communication in People with Dementia: A Randomized Controlled Trial
Conclusion: This study failed to document an overall effect of the Sonas programme on communication; however, the findings indicate that the Sonas programme has a significant effect on communication among those with severe dementia.Dement Geriatr Cogn Disord Extra 2017;7:122 –135 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - April 11, 2017 Category: Geriatrics Source Type: research

Gender Differences in Verbal and Visuospatial Working Memory Tasks in Patients with Mild Cognitive Impairment and Alzheimer Disease
Conclusion: Execution in visuospatial tasks tends to depend on gender, whereas this does not occur for verbal tasks.Dement Geriatr Cogn Disord Extra 2017;7:101 –108 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - April 3, 2017 Category: Geriatrics Source Type: research

Patients with Mild Cognitive Impairment Show Lower Visual Short-Term Memory Performance in Feature Binding Tasks 

Conclusion: Tasks that measure unimodal (object-location) and crossmodal (name-location) binding performance appear to be particularly effective for the detection of early cognitive changes in those at higher risk of developing dementia due to Alzheimer ’s disease.
Dement Geriatr Cogn Disord Extra (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - March 20, 2017 Category: Geriatrics Source Type: research

Disease Progression in Mild Dementia due to Alzheimer Disease in an 18-Month Observational Study (GERAS): The Impact on Costs and Caregiver Outcomes 

Conclusion: Cognitive and, more notably, functional decline were associated with increases in costs and caregiver outcomes in patients with mild AD dementia. 
Dement Geriatr Cogn Disord Extra (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - March 20, 2017 Category: Geriatrics Source Type: research

White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia 

We examined the relationship between white matter metrics and connected speech deficits using an automated analysis of transcriptions of connected speech and diffusion tensor imaging in language-related tracts. Syntactic, lexical, and semantic features were automatically extracted from transcriptions of topic-directed interviews conducted with groups of individuals with nfvPPA or svPPA as well as with a group of healthy controls. A principal component analysis was performed in order to reduce the number of language measures and yielded a five-factor solution. The results indicated that nfvPPA patients differed from healthy...
Source: Dementia and Geriatric Cognitive Disorders Extra - March 2, 2017 Category: Geriatrics Source Type: research

Effects of Nursing Home Residency on Diabetes Care in Individuals with Dementia: An Explorative Analysis Based on German Claims Data 

Conclusion: Dementia patients receive fewer DRMEs than recommended, especially in cases of higher care dependency and particularly in nursing homes. This suggests lacking awareness regarding the specific challenges of combined diabetes and dementia care. 
Dement Geriatr Cogn Disord Extra 2017;7:41 –51 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - February 10, 2017 Category: Geriatrics Source Type: research

Comedication and Treatment Length in Users of Acetylcholinesterase Inhibitors 

Conclusion: Coprescribing with potentially unfavorable medications was common. A high ADS score was associated with early discontinuation of treatment. 
Dement Geriatr Cogn Disord Extra 2017;7:30 –40 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - February 9, 2017 Category: Geriatrics Source Type: research

Subjective Cognitive Impairment Is a Predominantly Benign Condition in Memory Clinic Patients Followed for 6 Years: The Gothenburg-Oslo MCI Study 

Conclusions: Cognitive stability for 86% of the cohort suggests that SCI is predominantly a benign condition with regard to neuropathology. The low number of individuals who developed dementia limits the generalizability of the results and discussion of progression factors. 
Dement Geriatr Cogn Disord Extra 2017;7:1 –14 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - February 2, 2017 Category: Geriatrics Source Type: research

The Risk of Incident Mild Cognitive Impairment and Progression to Dementia Considering Mild Cognitive Impairment Subtypes 

Conclusions: Cognitively normal subjects with an APOE ε4 allele had a higher likelihood of developing aMCI and the MCI subtype was associated with the dementia subtype. Our findings provide important information about practical indicators for the prediction of cognitive decline.
Dement Geriatr Cogn Disord Extra 2017;7:15 –29 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - February 2, 2017 Category: Geriatrics Source Type: research

Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population 

Conclusions: Elevated serum UA levels were independently associated with cognitive deterioration. UA might have unknown adverse effects on cognitive function, other than causing vascular pathology. 
Dement Geriatr Cogn Disord Extra 2016;6:580 –588 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - December 23, 2016 Category: Geriatrics Source Type: research

Generalization of Context-Specific Training in Individuals with Mild Cognitive Impairment: An Event-Related Potential Study 

Conclusion: The results suggest that CS working memory is likely to be generalized to NCS domains among individuals with MCI. Future research should extend the scope of the generalization and apply it beyond experimental conditions. 
Dement Geriatr Cogn Disord Extra 2016;6:568 –579 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - December 15, 2016 Category: Geriatrics Source Type: research

Brain-Derived Neurotrophic Factor Serum Levels and Hippocampal Volume in Mild Cognitive Impairment and Dementia due to Alzheimer Disease
Discussion: The findings support that the decrease in BDNF might start before the establishment of neuronal injury expressed by the hippocampal reduction.Dement Geriatr Cogn Disord Extra 2016;6:559-567 (Source: Dementia and Geriatric Cognitive Disorders Extra)
Source: Dementia and Geriatric Cognitive Disorders Extra - December 8, 2016 Category: Geriatrics Source Type: research