The Role of the Vasculature in Heart Failure
AbstractThe contribution of the vasculature in the development and progression of heart failure (HF) syndromes is poorly understood and often neglected. Incorporating both arterial and venous systems, the vasculature plays a significant role in the regulation of blood flow throughout the body in meeting its metabolic requirements. A deterioration or imbalance between the cardiac and vascular interaction can precipitate acute decompensated HF in both preserved and reduced ejection fraction phenotypes. This is characterised by the increasingly recognised concept of ventricular-arterial coupling: a well-balanced relationship ...
Source: Current Heart Failure Reports - May 9, 2023 Category: Cardiology Source Type: research
PCSK9 Inhibition in Patients After Heart Transplantation: a Retrospective Review and Literature Analysis
This report supports that PCSK9 inhibitors should be considered following cardiac transplantation when conventional medial therapy is not tolerated or ineffective. (Source: Current Heart Failure Reports)
Source: Current Heart Failure Reports - May 8, 2023 Category: Cardiology Source Type: research
Management of Acute Right Ventricular Failure
AbstractPurpose of ReviewAcute right ventricular failure (RVF) is a frequent condition associated with high morbidity and mortality. This review aims to provide a current overview of the pathophysiology, presentation, and comprehensive management of acute RVF.Recent FindingsAcute RVF is a common disease with a pathophysiology that is not completely understood. There is renewed interest in the right ventricle (RV). Some advances have been principally made in chronic right ventricular failure (e.g., pulmonary hypertension). Due to a lack of precise definition and diagnostic tools, acute RVF is poorly studied. Few advances ha...
Source: Current Heart Failure Reports - May 8, 2023 Category: Cardiology Source Type: research
PCSK9 Inhibition in Patients After Heart Transplantation: a Retrospective Review and Literature Analysis
This report supports that PCSK9 inhibitors should be considered following cardiac transplantation when conventional medial therapy is not tolerated or ineffective. (Source: Current Heart Failure Reports)
Source: Current Heart Failure Reports - May 8, 2023 Category: Cardiology Source Type: research
Management of Acute Right Ventricular Failure
AbstractPurpose of ReviewAcute right ventricular failure (RVF) is a frequent condition associated with high morbidity and mortality. This review aims to provide a current overview of the pathophysiology, presentation, and comprehensive management of acute RVF.Recent FindingsAcute RVF is a common disease with a pathophysiology that is not completely understood. There is renewed interest in the right ventricle (RV). Some advances have been principally made in chronic right ventricular failure (e.g., pulmonary hypertension). Due to a lack of precise definition and diagnostic tools, acute RVF is poorly studied. Few advances ha...
Source: Current Heart Failure Reports - May 8, 2023 Category: Cardiology Source Type: research
Myocardial Fatigue at a Glance
AbstractExpanding on the modern lexicon of heart failure (HF), the novel mechano-energetic concept of myocardial fatigue describes a transiently energy-depleted myocardium with impaired contractility and relaxation in the face of adverse haemodynamic load. It encompasses established concepts of ventricular-arterial decoupling, deranged cardiac energetics and impaired myocardial efficiency, offering an alternative explanation for functional causes of HF. (Source: Current Heart Failure Reports)
Source: Current Heart Failure Reports - May 3, 2023 Category: Cardiology Source Type: research
Tricuspid Regurgitation: Right Ventricular Volume Versus Pressure Load
AbstractPurpose of the ReviewTricuspid regurgitation is associated with increased mortality in proportion to right ventricular adaptation to increased volume loading and pulmonary artery pressure. We here review recent progress in the understanding of right ventricular adaptation to pre- and after-loading conditions for improved recommendations of tricuspid valve repair.Recent FindingsTrans-catheter tricuspid valve repair has made the correction of tricuspid regurgitation more easily available, triggering a need of tighter indications. Several studies have shown the feasibility and relevance to the indications of tricuspid...
Source: Current Heart Failure Reports - April 26, 2023 Category: Cardiology Source Type: research
Do Women Physicians Accept and Follow Heart Failure Guidelines More Than Men?
AbstractPurpose of ReviewOur aim was to assess the degree of acceptance of the European Clinical Practice Guidelines (CPG) on heart failure (HF) among Spanish physicians according to sex. This was a cross-sectional study, employing Google Forms, conducted by a group of HF experts from the Region of Madrid (Spain), between November 2021 and February 2022, among specialists and residents of Cardiology, Internal Medicine, and Primary Care from Spain.Recent FindingsA total of 387 physicians —173 women (44.7%)—from 128 different centers completed the survey. Compared to men, women were significantly younger (38.2 ± 9.1...
Source: Current Heart Failure Reports - April 6, 2023 Category: Cardiology Source Type: research
Sudden Death in Men Versus Women with Heart Failure
Abstract
Purpose of ReviewSudden cardiac death (SCD) represents the most feared complication of heart failure (HF). This review intends to provide insight on our current knowledge of sex differences in SCD mechanisms, prevention, and management in HF patients.Recent FindingsWomen with HF present a better prognosis than men and have a lower incidence of SCD, irrespective of the presence of ischemic heart disease and age. The influence of sex hormones, sex differences in intracellular calcium handling, and a differential myocardial remodeling may explain such a gap between men and women. Both HF drugs and ventricular arrh...
Source: Current Heart Failure Reports - April 1, 2023 Category: Cardiology Source Type: research
Challenges and Opportunities in Titrating Disease-Modifying Therapies in Heart Failure with Reduced Ejection Fraction and Chronic Kidney Disease
AbstractPurpose of ReviewChronic kidney disease (CKD) is highly prevalent in patients with heart failure and reduced ejection fraction (HFrEF), representing a major factor of adverse outcomes. In clinical practice, it is one of the main reasons for not initiating, not titrating, and even withdrawing efficient heart failure drug therapies in patients.Recent FindingsDespite limited data, studies show that HFrEF therapies maintain their benefits on cardiovascular outcomes in patients with CKD. Most HF drugs cause acute renal haemodynamic changes, but with stabilisation or even improvement after the acute phase, thus with no l...
Source: Current Heart Failure Reports - February 28, 2023 Category: Cardiology Source Type: research
