Anthracycline-Related Heart Failure: Certain Knowledge and Open Questions
AbstractIn the last decade, cardio-oncology has become a discipline on its own, with tremendous research going on to unravel the mechanisms underpinning different manifestations of cardiotoxicity caused by anticancer drugs. Although this domain is much broader than the effect of chemotherapy alone, a lot of questions about anthracycline-induced cardiotoxicity remain unknown. In this invited review, we provide insights in molecular mechanisms behind anthracycline-induced cardiotoxicity and put it in a clinical framework emphasizing the need for patients to understand, detect, and treat this detrimental condition. (Source: C...
Source: Current Heart Failure Reports - September 22, 2020 Category: Cardiology Source Type: research
Do Natriuretic Peptide Measurements Provide Insights into Management of End-Stage Renal Disease Patients Undergoing Dialysis?
AbstractPurpose of ReviewImpaired renal function may affect natriuretic peptide levels through a variety of factors and mechanisms, such as high prevalence of concomitant vascular and myocardial diseases, reduced clearance, increased risk of volume overload, and different types and solute removal techniques in the setting of dialysis. Nevertheless, accumulating evidence suggests that natriuretic peptide testing may provide insights into management of patients with chronic kidney disease (CKD) and end-stage kidney disease (ESRD) on dialysis, as they have been shown to be independently associated with morbidity and mortality...
Source: Current Heart Failure Reports - September 16, 2020 Category: Cardiology Source Type: research
The New Era of Cardiogenic Shock: Progress in Mechanical Circulatory Support
AbstractPurpose of ReviewIn recent decades, multiple left and right ventricular assist devices (VAD) have been developed, and the utilization of these devices has grown exponentially. We discuss the most common temporary mechanical circulatory support (tMCS) devices used for patients in cardiogenic shock, including the intra-aortic balloon pump (IABP), transvalvular axial flow support systems (Impella ®), the Tandem™ collection, and extracorporeal membrane oxygenation (ECMO).Recent FindingsIn 2018 the United Network for Organ Sharing (UNOS) introduced new listing criteria for candidates awaiting heart transplantation in...
Source: Current Heart Failure Reports - September 15, 2020 Category: Cardiology Source Type: research
Correction to: Cardiac Magnetic Resonance Imaging in Pulmonary Arterial Hypertension: Ready for Clinical Practice and Guidelines?
The original version of this article contains error in the text. (Source: Current Heart Failure Reports)
Source: Current Heart Failure Reports - September 13, 2020 Category: Cardiology Source Type: research
Rethinking the Meaning of Palliation in Heart Failure
AbstractPurpose of ReviewPalliative care follows a philosophy of care that focuses upon the quality of life in patients with chronic or life-threatening illness. It also focuses upon the needs of their families which is a wider scope of care. Cardiovascular disease, and specifically heart failure, affects millions of patients and family members who have a symptom burden that exceeds that of many cancers and other chronic diseases.Recently FindingsHistorically palliative care has been viewed as an alternative to curative therapies, but over time, it is now recognized that it should be implemented earlier in the course of ch...
Source: Current Heart Failure Reports - September 1, 2020 Category: Cardiology Source Type: research
