Biomarkers in Duchenne Muscular Dystrophy
AbstractPurpose of ReviewThis review highlights the key studies investigating various types of biomarkers in Duchenne muscular dystrophy (DMD).Recent FindingsSeveral proteomic and metabolomic studies have been undertaken in both human DMD patients and animal models of DMD that have identified potential biomarkers in DMD.SummaryAlthough there have been a number of proteomic and metabolomic studies that have identified various potential biomarkers in DMD, more definitive studies still need to be undertaken in DMD patients to firmly correlate these biomarkers with diagnosis, disease progression, and monitoring the effects of ...
Source: Current Heart Failure Reports - April 7, 2022 Category: Cardiology Source Type: research
Epidemiology of Asymptomatic Pre-heart Failure: a Systematic Review
AbstractPurpose of ReviewTo quantify the prevalence of asymptomatic pre-heart failure (pre-HF), progression to more severe stages, and associated mortality.Recent FindingsA systematic review was conducted between 01 January 2010 and 12 March 2020 (PROSPERO: CRD42020176141). Data of interest included prevalence, disease progression, and mortality rates. In total, 1030 sources were identified, of which, 12 reported on pre-HF (using the ACC/AHA definition for stage B HF) and were eligible. Prevalence estimates of pre-HF ranged from 11 to 42.7% (10 sources) with higher estimates found in the elderly, in patients with hypertens...
Source: Current Heart Failure Reports - March 30, 2022 Category: Cardiology Source Type: research
LVEF by Multigated Acquisition Scan Compared to Other Imaging Modalities in Cardio-Oncology: a Systematic Review
AbstractPurpose of ReviewThe prevalence of cancer therapy-related cardiac dysfunction (CTRCD) is increasing due to improved cancer survival. Serial monitoring of cardiac function is essential to detect CTRCD, guiding timely intervention strategies. Multigated radionuclide angiography (MUGA) has been the main screening tool using left ventricular ejection fraction (LVEF) to monitor cardiac dysfunction. However, transthoracic echocardiography (TTE) and cardiac magnetic resonance imaging (CMR) may be more suitable for serial assessment. We aimed to assess the concordance between different non-radiating imaging modalities with...
Source: Current Heart Failure Reports - March 30, 2022 Category: Cardiology Source Type: research
Management of Atrial Tachyarrhythmias in Heart Failure —an Interventionalist’s Point of View
AbstractPurpose of ReviewAtrial fibrillation (AF) and heart failure (HF) are commonly encountered clinical disorders that often co-exist, accelerating disease progression and adverse outcomes. It is known that restoration of sinus rhythm positively impacts this population; however, the complex comorbidity profile associated with HF introduces intricacies not encountered in other patient populations. The current review focuses on the safety and efficacy of an interventional-based management for atrial tachyarrhythmias in HF.Recent FindingsWhile pharmacotherapy has been the standard treatment of cardiac dysrhythmias in the H...
Source: Current Heart Failure Reports - March 30, 2022 Category: Cardiology Source Type: research
Telemedical Monitoring Based on Implantable Devices —the Evolution Beyond the CardioMEMS™ Technology
AbstractPurpose of the ReviewWe aimed to provide an overview of telemedical monitoring and its impact on outcomes among heart failure (HF) patients.Recent FindingsMost HF readmissions may be prevented if clinical parameters are strictly controlled via telemedical monitoring. Predictive algorithms for patients with cardiovascular implantable electronic devices (e.g., Triage-HF Plus by Medtronic or HeartLogic by Boston Scientific) were developed to identify patients at significantly increased risk of HF events. However, randomized control trial-based data are heterogeneous regarding the advantages of telemedical monitoring i...
Source: Current Heart Failure Reports - February 16, 2022 Category: Cardiology Source Type: research
Mitochondria as Therapeutic Targets in Heart Failure
AbstractPurpose of ReviewWe review therapeutic approaches aimed at restoring function of the failing heart by targeting mitochondrial reactive oxygen species (ROS), ion handling, and substrate utilization for adenosine triphosphate (ATP) production.Recent FindingsMitochondria-targeted therapies have been tested in animal models of and humans with heart failure (HF). Cardiac benefits of sodium/glucose cotransporter 2 inhibitors might be partly explained by their effects on ion handling and metabolism of cardiac myocytes.SummaryThe large energy requirements of the heart are met by oxidative phosphorylation in mitochondria, w...
Source: Current Heart Failure Reports - February 11, 2022 Category: Cardiology Source Type: research
Decision Support Systems in HF based on Deep Learning Technologies
AbstractPurpose of ReviewApplication of deep learning (DL) is growing in the last years, especially in the healthcare domain. This review presents the current state of DL techniques applied to electronic health record structured data, physiological signals, and imaging modalities for the management of heart failure (HF), focusing in particular on diagnosis, prognosis, and re-hospitalization risk, to explore the level of maturity of DL in this field.Recent FindingsDL allows a better integration of different data sources to distillate more accurate outcomes in HF patients, thus resulting in better performance when compared t...
Source: Current Heart Failure Reports - February 10, 2022 Category: Cardiology Source Type: research
Telemedical Monitoring Based on Implantable Devices —the Evolution Beyond the CardioMEMS™ Technology
AbstractPurpose of the ReviewWe aimed to provide an overview of telemedical monitoring and its impact on outcomes among heart failure (HF) patients.Recent FindingsMost HF readmissions may be prevented if clinical parameters are strictly controlled via telemedical monitoring. Predictive algorithms for patients with cardiovascular implantable electronic devices (e.g., Triage-HF Plus by Medtronic or HeartLogic by Boston Scientific) were developed to identify patients at significantly increased risk of HF events. However, randomized control trial-based data are heterogeneous regarding the advantages of telemedical monitoring i...
Source: Current Heart Failure Reports - February 1, 2022 Category: Cardiology Source Type: research
Personalizing Heart Failure Care to the Patient With Cancer
AbstractPurpose of ReviewThe current review describes the role of the cardio-oncology nurse and the need for personalized heart failure care for the patient with cancer.Recent FindingsIt is a new role whereby cardiology or heart failure nurses care for patients with cancer who develop cardiotoxicity or cardiovascular diseases, either during the cancer therapy or in a later stage. Inter-disciplinary approach is important for individualized early treatment, shortened interruptions to cancer therapy, and irreversible cardiovascular injury prevention. Nurses have a key role in early evaluation and quality control of the care p...
Source: Current Heart Failure Reports - February 1, 2022 Category: Cardiology Source Type: research
Impact of Loop Diuretic on Outcomes in Patients with Heart Failure and Reduced Ejection Fraction
AbstractPurpose of ReviewLoop diuretics are the cornerstone of the treatment of congestion in heart failure patients. The manuscript aims to summarize the most updated information regarding the use of loop diuretics in heart failure.Recent FindingsDiuretic response can be highly variable between patients and needs to be carefully evaluated during and after the hospitalization. Diuretic resistance can lead to residual congestion which affects prognosis and can be difficult to detect. The effect of loop diuretics on long-term prognosis remains uncertain but patients with advanced heart failure typically have renal dysfunctio...
Source: Current Heart Failure Reports - February 1, 2022 Category: Cardiology Source Type: research
Personalizing Heart Failure Care to the Patient With Cancer
AbstractPurpose of ReviewThe current review describes the role of the cardio-oncology nurse and the need for personalized heart failure care for the patient with cancer.Recent FindingsIt is a new role whereby cardiology or heart failure nurses care for patients with cancer who develop cardiotoxicity or cardiovascular diseases, either during the cancer therapy or in a later stage. Inter-disciplinary approach is important for individualized early treatment, shortened interruptions to cancer therapy, and irreversible cardiovascular injury prevention. Nurses have a key role in early evaluation and quality control of the care p...
Source: Current Heart Failure Reports - January 9, 2022 Category: Cardiology Source Type: research
Heart Failure in Breast Cancer Survivors: Focus on Early Detection and Novel Biomarkers
AbstractPurpose of Review
Breast cancer survival rate has greatly improved in the last two decades due to the emergence of next-generation anti-cancer agents. However, cardiotoxicity remains a significant adverse effect arising from traditional and emerging chemotherapies as well as targeted therapies for breast cancer patients. In this review, we will discuss cardiotoxicities of both traditional and emerging therapies for breast cancer. We will discuss current practices to detect cardiotoxicity of these therapies with the focus on new and emerging biomarkers. We will then focus on ‘omics approaches, especially the us...
Source: Current Heart Failure Reports - December 1, 2021 Category: Cardiology Source Type: research
