Inappropriate use of proton pump inhibitor among elderly patients in British Columbia: what are the long-term adverse events?
CONCLUSION: This study revealed a high prevalence of PPI use among elderly populations in BC, Canada. The overutilization of PPIs is often a result of failure to re-evaluate the need for continuation of therapy. Published studies identified signals of serious harm from long-term PPI exposure. Healthcare providers with patients can reverse the relentless expansion of long-term PPI exposure by discussing the expected benefits and potential harms.PMID:37496243 | DOI:10.2174/1574886318666230726124540 (Source: Current Drug Safety)
Source: Current Drug Safety - July 27, 2023 Category: Drugs & Pharmacology Authors: Mohamed Ben-Eltriki Manik Chhabra Alan Cassels James M Wright Source Type: research
Multiple sclerosis risk among anti-tumor necrosis factor alpha users: A methodological review of observational studies based on real-world data
This article demonstrates how cDAGs can be used to determine whether there is a confounder, a mediator or collider-stratification bias and when to adjust for them appropriately. We also use a case study to show how to control for potential biases by drawing a cDAG depicting anti-TNFαalpha; use and its potential to contribute to MS onset. Finally, we describe potential biases that might have led to contradictory results in previous studies that examined the effect of anti-TNFαalpha; and MS, including confounding, confounding by contraindication, and bias due to measurement error. Clinicians and researchers should be cogni...
Source: Current Drug Safety - July 27, 2023 Category: Drugs & Pharmacology Authors: Lingyi Li Mahyar Etminan Gilaad G Kaplan Helen Tremlett Hui Xie J Antonio Avi ña-Zubieta Source Type: research
The Gambia death story: 66 children died!
Curr Drug Saf. 2023 Jul 26. doi: 10.2174/1574886318666230726161911. Online ahead of print.NO ABSTRACTPMID:37496139 | DOI:10.2174/1574886318666230726161911 (Source: Current Drug Safety)
Source: Current Drug Safety - July 27, 2023 Category: Drugs & Pharmacology Authors: Sumel Ashique Source Type: research
Inappropriate use of proton pump inhibitor among elderly patients in British Columbia: what are the long-term adverse events?
CONCLUSION: This study revealed a high prevalence of PPI use among elderly populations in BC, Canada. The overutilization of PPIs is often a result of failure to re-evaluate the need for continuation of therapy. Published studies identified signals of serious harm from long-term PPI exposure. Healthcare providers with patients can reverse the relentless expansion of long-term PPI exposure by discussing the expected benefits and potential harms.PMID:37496243 | DOI:10.2174/1574886318666230726124540 (Source: Current Drug Safety)
Source: Current Drug Safety - July 27, 2023 Category: Drugs & Pharmacology Authors: Mohamed Ben-Eltriki Manik Chhabra Alan Cassels James M Wright Source Type: research
Multiple sclerosis risk among anti-tumor necrosis factor alpha users: A methodological review of observational studies based on real-world data
This article demonstrates how cDAGs can be used to determine whether there is a confounder, a mediator or collider-stratification bias and when to adjust for them appropriately. We also use a case study to show how to control for potential biases by drawing a cDAG depicting anti-TNFαalpha; use and its potential to contribute to MS onset. Finally, we describe potential biases that might have led to contradictory results in previous studies that examined the effect of anti-TNFαalpha; and MS, including confounding, confounding by contraindication, and bias due to measurement error. Clinicians and researchers should be cogni...
Source: Current Drug Safety - July 27, 2023 Category: Drugs & Pharmacology Authors: Lingyi Li Mahyar Etminan Gilaad G Kaplan Helen Tremlett Hui Xie J Antonio Avi ña-Zubieta Source Type: research
Erythema multiforme reactions following Pfizer/BioNTech (tozinameran) vaccination: two case-reports with positive rechallenge and review of the literature
CONCLUSION: Few cases of EM following COVID-19 vaccination were reported in the literature and positive rechallenge in only one case. Rechallenge was not performed in most cases. Our two cases are particular because of the positive rechallenge in both patients. This is the gold standard to confirm that the vaccine was the culprit agent in inducing EM.PMID:37489779 | DOI:10.2174/1574886318666230725101846 (Source: Current Drug Safety)
Source: Current Drug Safety - July 25, 2023 Category: Drugs & Pharmacology Authors: Ons Charfi Ghozlane Lakhoua Khouloud Berrim Sarrah Kastalli Imen Aouinti Talel Badri Riadh Daghfous Ahmed Zaiem Sihem El Aidli Source Type: research
Tizanidine induced hypotension: report of a case and review of literature
CONCLUSION: This patient highlights the need for close monitoring of patients receiving tizanidine co-medication with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. These drugs have a synergistic effect on reducing the renin-angiotensin-aldosterone system, thereby hypotension and bradycardia.PMID:37489780 | DOI:10.2174/1574886318666230725113855 (Source: Current Drug Safety)
Source: Current Drug Safety - July 25, 2023 Category: Drugs & Pharmacology Authors: Roopali Mahajan Jayantee Kalita Source Type: research
Erythema multiforme reactions following Pfizer/BioNTech (tozinameran) vaccination: two case-reports with positive rechallenge and review of the literature
CONCLUSION: Few cases of EM following COVID-19 vaccination were reported in the literature and positive rechallenge in only one case. Rechallenge was not performed in most cases. Our two cases are particular because of the positive rechallenge in both patients. This is the gold standard to confirm that the vaccine was the culprit agent in inducing EM.PMID:37489779 | DOI:10.2174/1574886318666230725101846 (Source: Current Drug Safety)
Source: Current Drug Safety - July 25, 2023 Category: Drugs & Pharmacology Authors: Ons Charfi Ghozlane Lakhoua Khouloud Berrim Sarrah Kastalli Imen Aouinti Talel Badri Riadh Daghfous Ahmed Zaiem Sihem El Aidli Source Type: research
Tizanidine induced hypotension: report of a case and review of literature
CONCLUSION: This patient highlights the need for close monitoring of patients receiving tizanidine co-medication with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. These drugs have a synergistic effect on reducing the renin-angiotensin-aldosterone system, thereby hypotension and bradycardia.PMID:37489780 | DOI:10.2174/1574886318666230725113855 (Source: Current Drug Safety)
Source: Current Drug Safety - July 25, 2023 Category: Drugs & Pharmacology Authors: Roopali Mahajan Jayantee Kalita Source Type: research
The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity: Time to Revise Guidelines
CONCLUSION: In this case of thiopurine toxicity, a patient with autoimmune hepatitis presents with abdominal pain, nausea, vomiting, and diarrhea. We show in this case report that renal replacement therapy had no effect on total body clearance of mercaptopurine.PMID:37455454 | DOI:10.2174/1574886318666230714105801 (Source: Current Drug Safety)
Source: Current Drug Safety - July 17, 2023 Category: Drugs & Pharmacology Authors: Quaedvlieg Hjl Polderman Fn Borkent M De Jonge Hjm Annema Pa Derijks Ljj Sikma Ma Bethlehem C Source Type: research
The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity: Time to Revise Guidelines
CONCLUSION: In this case of thiopurine toxicity, a patient with autoimmune hepatitis presents with abdominal pain, nausea, vomiting, and diarrhea. We show in this case report that renal replacement therapy had no effect on total body clearance of mercaptopurine.PMID:37455454 | DOI:10.2174/1574886318666230714105801 (Source: Current Drug Safety)
Source: Current Drug Safety - July 17, 2023 Category: Drugs & Pharmacology Authors: Quaedvlieg Hjl Polderman Fn Borkent M De Jonge Hjm Annema Pa Derijks Ljj Sikma Ma Bethlehem C Source Type: research
The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity: Time to Revise Guidelines
CONCLUSION: In this case of thiopurine toxicity, a patient with autoimmune hepatitis presents with abdominal pain, nausea, vomiting, and diarrhea. We show in this case report that renal replacement therapy had no effect on total body clearance of mercaptopurine.PMID:37455454 | DOI:10.2174/1574886318666230714105801 (Source: Current Drug Safety)
Source: Current Drug Safety - July 17, 2023 Category: Drugs & Pharmacology Authors: Quaedvlieg Hjl Polderman Fn Borkent M De Jonge Hjm Annema Pa Derijks Ljj Sikma Ma Bethlehem C Source Type: research
The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity: Time to Revise Guidelines
CONCLUSION: In this case of thiopurine toxicity, a patient with autoimmune hepatitis presents with abdominal pain, nausea, vomiting, and diarrhea. We show in this case report that renal replacement therapy had no effect on total body clearance of mercaptopurine.PMID:37455454 | DOI:10.2174/1574886318666230714105801 (Source: Current Drug Safety)
Source: Current Drug Safety - July 17, 2023 Category: Drugs & Pharmacology Authors: Quaedvlieg Hjl Polderman Fn Borkent M De Jonge Hjm Annema Pa Derijks Ljj Sikma Ma Bethlehem C Source Type: research
The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity: Time to Revise Guidelines
CONCLUSION: In this case of thiopurine toxicity, a patient with autoimmune hepatitis presents with abdominal pain, nausea, vomiting, and diarrhea. We show in this case report that renal replacement therapy had no effect on total body clearance of mercaptopurine.PMID:37455454 | DOI:10.2174/1574886318666230714105801 (Source: Current Drug Safety)
Source: Current Drug Safety - July 17, 2023 Category: Drugs & Pharmacology Authors: Quaedvlieg Hjl Polderman Fn Borkent M De Jonge Hjm Annema Pa Derijks Ljj Sikma Ma Bethlehem C Source Type: research
The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity: Time to Revise Guidelines
CONCLUSION: In this case of thiopurine toxicity, a patient with autoimmune hepatitis presents with abdominal pain, nausea, vomiting, and diarrhea. We show in this case report that renal replacement therapy had no effect on total body clearance of mercaptopurine.PMID:37455454 | DOI:10.2174/1574886318666230714105801 (Source: Current Drug Safety)
Source: Current Drug Safety - July 17, 2023 Category: Drugs & Pharmacology Authors: Quaedvlieg Hjl Polderman Fn Borkent M De Jonge Hjm Annema Pa Derijks Ljj Sikma Ma Bethlehem C Source Type: research
