Securin acetylation prevents precocious separase activation and premature sister chromatid separation
In this study, we examine the role of lysine acetylation during sister chromatid separation in mitosis. We investigate the acetylation of securin at K21 by cell-cycle-dependent acetylome analysis and uncover its role in separase-triggered chromosome segregation during mitosis. Prior to the onset of anaphase, the acetylated securin via TIP60 prevents its degradation by the APC/CCDC20-mediated ubiquitin-proteasome system. This, in turn, restrains precocious activation of separase and premature separation of sister chromatids. Additionally, the acetylation-dependent stability of securin is also enhanced by its dephosphorylati...
Source: Current Biology - March 7, 2024 Category: Biology Authors: Tianning Wang Yuhong Zou Hui Meng Pengli Zheng Junlin Teng Ning Huang Jianguo Chen Source Type: research
Local people enhance our understanding of Afrotropical frugivory networks
Curr Biol. 2024 Feb 23:S0960-9822(24)00166-0. doi: 10.1016/j.cub.2024.02.026. Online ahead of print.ABSTRACTAfrotropical forests are undergoing massive change caused by defaunation, i.e., the human-induced decline of animal species,1 most of which are frugivorous species.1,2,3 Frugivores' depletion and their functional disappearance are expected to cascade on tree dispersal and forest structure via interaction networks,4,5,6,7 as the majority of tree species depend on frugivores for their dispersal.8 However, frugivory networks remain largely unknown, especially in Afrotropical areas,9,10,11 which considerably limits our a...
Source: Current Biology - March 7, 2024 Category: Biology Authors: Cl émentine Durand-Bessart Etienne Fran çois Akomo-Okoue Ghislain Wilfried Ebang Ella Vincent Porcher Paul Yannick Bitome Essono Fran çois Bretagnolle Colin Fontaine Source Type: research
Securin acetylation prevents precocious separase activation and premature sister chromatid separation
In this study, we examine the role of lysine acetylation during sister chromatid separation in mitosis. We investigate the acetylation of securin at K21 by cell-cycle-dependent acetylome analysis and uncover its role in separase-triggered chromosome segregation during mitosis. Prior to the onset of anaphase, the acetylated securin via TIP60 prevents its degradation by the APC/CCDC20-mediated ubiquitin-proteasome system. This, in turn, restrains precocious activation of separase and premature separation of sister chromatids. Additionally, the acetylation-dependent stability of securin is also enhanced by its dephosphorylati...
Source: Current Biology - March 7, 2024 Category: Biology Authors: Tianning Wang Yuhong Zou Hui Meng Pengli Zheng Junlin Teng Ning Huang Jianguo Chen Source Type: research
Local people enhance our understanding of Afrotropical frugivory networks
Curr Biol. 2024 Feb 23:S0960-9822(24)00166-0. doi: 10.1016/j.cub.2024.02.026. Online ahead of print.ABSTRACTAfrotropical forests are undergoing massive change caused by defaunation, i.e., the human-induced decline of animal species,1 most of which are frugivorous species.1,2,3 Frugivores' depletion and their functional disappearance are expected to cascade on tree dispersal and forest structure via interaction networks,4,5,6,7 as the majority of tree species depend on frugivores for their dispersal.8 However, frugivory networks remain largely unknown, especially in Afrotropical areas,9,10,11 which considerably limits our a...
Source: Current Biology - March 7, 2024 Category: Biology Authors: Cl émentine Durand-Bessart Etienne Fran çois Akomo-Okoue Ghislain Wilfried Ebang Ella Vincent Porcher Paul Yannick Bitome Essono Fran çois Bretagnolle Colin Fontaine Source Type: research
The hierarchical radiation of phyllostomid bats as revealed by adaptive molar morphology
Curr Biol. 2024 Feb 29:S0960-9822(24)00169-6. doi: 10.1016/j.cub.2024.02.027. Online ahead of print.ABSTRACTAdaptive radiations are bursts in biodiversity that generate new evolutionary lineages and phenotypes. However, because they typically occur over millions of years, it is unclear how their macroevolutionary dynamics vary through time and among groups of organisms. Phyllostomid bats radiated extensively for diverse diets-from insects to vertebrates, fruit, nectar, and blood-and we use their molars as a model system to examine the dynamics of adaptive radiations. Three-dimensional shape analyses of lower molars of Noct...
Source: Current Biology - March 6, 2024 Category: Biology Authors: David M Grossnickle Alexa Sadier Edward Patterson Nashaly N Cort és-Viruet Stephanie M Jim énez-Rivera Karen E Sears Sharlene E Santana Source Type: research
The hierarchical radiation of phyllostomid bats as revealed by adaptive molar morphology
Curr Biol. 2024 Feb 29:S0960-9822(24)00169-6. doi: 10.1016/j.cub.2024.02.027. Online ahead of print.ABSTRACTAdaptive radiations are bursts in biodiversity that generate new evolutionary lineages and phenotypes. However, because they typically occur over millions of years, it is unclear how their macroevolutionary dynamics vary through time and among groups of organisms. Phyllostomid bats radiated extensively for diverse diets-from insects to vertebrates, fruit, nectar, and blood-and we use their molars as a model system to examine the dynamics of adaptive radiations. Three-dimensional shape analyses of lower molars of Noct...
Source: Current Biology - March 6, 2024 Category: Biology Authors: David M Grossnickle Alexa Sadier Edward Patterson Nashaly N Cort és-Viruet Stephanie M Jim énez-Rivera Karen E Sears Sharlene E Santana Source Type: research
Tactile localization promotes infant self-recognition in the mirror-mark test
Curr Biol. 2024 Feb 27:S0960-9822(24)00170-2. doi: 10.1016/j.cub.2024.02.028. Online ahead of print.ABSTRACTMirror self-recognition has been hailed by many as a milestone in the acquisition of self-awareness with respect to phylogenesis and human ontogenesis.1,2,3,4,5,6 Yet there has been considerable controversy over the extent to which species other than humans and their closest primate relatives are capable of mirror self-recognition, and to the mechanisms that give rise to this ability.1,7 One influential view is that mirror self-recognition in humans and their closest primate relatives is a cognitive advance that is a...
Source: Current Biology - March 5, 2024 Category: Biology Authors: Lisa K Chinn Claire F Noonan Katarina S Patton Jeffrey J Lockman Source Type: research
Incomplete immunity in a natural animal-microbiota interaction selects for higher pathogen virulence
Curr Biol. 2024 Feb 23:S0960-9822(24)00157-X. doi: 10.1016/j.cub.2024.02.015. Online ahead of print.ABSTRACTIncomplete immunity in recovered hosts is predicted to favor more virulent pathogens upon re-infection in the population.1 The microbiota colonizing animals can generate a similarly long-lasting, partial immune response, allowing for infection but dampened disease severity.2 We tracked the evolutionary trajectories of a widespread pathogen (Pseudomonas aeruginosa), experimentally passaged through populations of nematodes immune-primed by a natural microbiota member (P. berkeleyensis). This bacterium can induce genes ...
Source: Current Biology - March 2, 2024 Category: Biology Authors: Kim L Hoang Timothy D Read Kayla C King Source Type: research
Incomplete immunity in a natural animal-microbiota interaction selects for higher pathogen virulence
Curr Biol. 2024 Feb 23:S0960-9822(24)00157-X. doi: 10.1016/j.cub.2024.02.015. Online ahead of print.ABSTRACTIncomplete immunity in recovered hosts is predicted to favor more virulent pathogens upon re-infection in the population.1 The microbiota colonizing animals can generate a similarly long-lasting, partial immune response, allowing for infection but dampened disease severity.2 We tracked the evolutionary trajectories of a widespread pathogen (Pseudomonas aeruginosa), experimentally passaged through populations of nematodes immune-primed by a natural microbiota member (P. berkeleyensis). This bacterium can induce genes ...
Source: Current Biology - March 2, 2024 Category: Biology Authors: Kim L Hoang Timothy D Read Kayla C King Source Type: research
Incomplete immunity in a natural animal-microbiota interaction selects for higher pathogen virulence
Curr Biol. 2024 Feb 23:S0960-9822(24)00157-X. doi: 10.1016/j.cub.2024.02.015. Online ahead of print.ABSTRACTIncomplete immunity in recovered hosts is predicted to favor more virulent pathogens upon re-infection in the population.1 The microbiota colonizing animals can generate a similarly long-lasting, partial immune response, allowing for infection but dampened disease severity.2 We tracked the evolutionary trajectories of a widespread pathogen (Pseudomonas aeruginosa), experimentally passaged through populations of nematodes immune-primed by a natural microbiota member (P. berkeleyensis). This bacterium can induce genes ...
Source: Current Biology - March 2, 2024 Category: Biology Authors: Kim L Hoang Timothy D Read Kayla C King Source Type: research
Post-invasion selection acts on standing genetic variation despite a severe founding bottleneck
Curr Biol. 2024 Feb 21:S0960-9822(24)00152-0. doi: 10.1016/j.cub.2024.02.010. Online ahead of print.ABSTRACTInvasive populations often have lower genetic diversity relative to the native-range populations from which they derive.1,2 Despite this, many biological invaders succeed in their new environments, in part due to rapid adaptation.3,4,5,6 Therefore, the role of genetic bottlenecks in constraining the adaptation of invaders is debated.7,8,9,10 Here, we use whole-genome resequencing of samples from a 10-year time-series dataset, representing the natural invasion of the Asian honey bee (Apis cerana) in Australia, to inve...
Source: Current Biology - March 1, 2024 Category: Biology Authors: Kathleen A Dogantzis Rika Raffiudin Ramadhani Eka Putra Ismail Shaleh Ida M Conflitti Mateus Pepinelli John Roberts Michael Holmes Benjamin P Oldroyd Amro Zayed Rosalyn Gloag Source Type: research
Collective cell migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress response
Curr Biol. 2024 Feb 27:S0960-9822(24)00156-8. doi: 10.1016/j.cub.2024.02.014. Online ahead of print.ABSTRACTCollective cell migration is integral to many developmental and disease processes. Previously, we discovered that protein phosphatase 1 (Pp1) promotes border cell collective migration in the Drosophila ovary. We now report that the Pp1 phosphatase regulatory subunit dPPP1R15 is a critical regulator of border cell migration. dPPP1R15 is an ortholog of mammalian PPP1R15 proteins that attenuate the endoplasmic reticulum (ER) stress response. We show that, in collectively migrating border cells, dPPP1R15 phosphatase rest...
Source: Current Biology - March 1, 2024 Category: Biology Authors: Yujun Chen Jocelyn A McDonald Source Type: research
Host adaptive radiation is associated with rapid virus diversification and cross-species transmission in African cichlid fishes
We examined how the rapid adaptive radiation of the cichlid fishes of African Lake Tanganyika over the last 10 million years has shaped the diversity and evolution of the viruses they carry. Through metatranscriptomic analysis of 2,242 RNA sequencing libraries, we identified 121 vertebrate-associated viruses among various tissue types that fell into 13 RNA and 4 DNA virus groups. Host-switching was commonplace, particularly within the Astroviridae, Metahepadnavirus, Nackednavirus, Picornaviridae, and Hepacivirus groups, occurring more frequently than in other fish communities. A time-calibrated phylogeny revealed that hepa...
Source: Current Biology - March 1, 2024 Category: Biology Authors: Vincenzo A Costa Fabrizia Ronco Jonathon C O Mifsud Erin Harvey Walter Salzburger Edward C Holmes Source Type: research
Post-invasion selection acts on standing genetic variation despite a severe founding bottleneck
Curr Biol. 2024 Feb 21:S0960-9822(24)00152-0. doi: 10.1016/j.cub.2024.02.010. Online ahead of print.ABSTRACTInvasive populations often have lower genetic diversity relative to the native-range populations from which they derive.1,2 Despite this, many biological invaders succeed in their new environments, in part due to rapid adaptation.3,4,5,6 Therefore, the role of genetic bottlenecks in constraining the adaptation of invaders is debated.7,8,9,10 Here, we use whole-genome resequencing of samples from a 10-year time-series dataset, representing the natural invasion of the Asian honey bee (Apis cerana) in Australia, to inve...
Source: Current Biology - March 1, 2024 Category: Biology Authors: Kathleen A Dogantzis Rika Raffiudin Ramadhani Eka Putra Ismail Shaleh Ida M Conflitti Mateus Pepinelli John Roberts Michael Holmes Benjamin P Oldroyd Amro Zayed Rosalyn Gloag Source Type: research
Collective cell migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress response
Curr Biol. 2024 Feb 27:S0960-9822(24)00156-8. doi: 10.1016/j.cub.2024.02.014. Online ahead of print.ABSTRACTCollective cell migration is integral to many developmental and disease processes. Previously, we discovered that protein phosphatase 1 (Pp1) promotes border cell collective migration in the Drosophila ovary. We now report that the Pp1 phosphatase regulatory subunit dPPP1R15 is a critical regulator of border cell migration. dPPP1R15 is an ortholog of mammalian PPP1R15 proteins that attenuate the endoplasmic reticulum (ER) stress response. We show that, in collectively migrating border cells, dPPP1R15 phosphatase rest...
Source: Current Biology - March 1, 2024 Category: Biology Authors: Yujun Chen Jocelyn A McDonald Source Type: research
