Sequential activity of CA1 hippocampal cells constitutes a temporal memory map for associative learning in mice
Curr Biol. 2024 Feb 6:S0960-9822(24)00021-6. doi: 10.1016/j.cub.2024.01.021. Online ahead of print.ABSTRACTSequential neural dynamics encoded by time cells play a crucial role in hippocampal function. However, the role of hippocampal sequential neural dynamics in associative learning is an open question. We used two-photon Ca2+ imaging of dorsal CA1 (dCA1) neurons in the stratum pyramidale (SP) in head-fixed mice performing a go-no go associative learning task to investigate how odor valence is temporally encoded in this area of the brain. We found that SP cells responded differentially to the rewarded or unrewarded odor. ...
Source: Current Biology - February 7, 2024 Category: Biology Authors: Ming Ma Fabio Simoes de Souza Gregory L Futia Sean R Anderson Jose Riguero Daniel Tollin Arianna Gentile-Polese Jonathan P Platt Kira Steinke Naoki Hiratani Emily A Gibson Diego Restrepo Source Type: research
Rediversification following ecotype isolation reveals hidden adaptive potential
Curr Biol. 2024 Feb 1:S0960-9822(24)00029-0. doi: 10.1016/j.cub.2024.01.029. Online ahead of print.ABSTRACTMicrobial communities play a critical role in ecological processes, and their diversity is key to their functioning. However, little is known about whether communities can regenerate ecological diversity following ecotype removal or extinction and how the rediversified communities would compare to the original ones. Here, we show that simple two-ecotype communities from the E. coli long-term evolution experiment (LTEE) consistently rediversified into two ecotypes following the isolation of one of the ecotypes, coexist...
Source: Current Biology - February 7, 2024 Category: Biology Authors: Joao A Ascensao Jonas Denk Kristen Lok QinQin Yu Kelly M Wetmore Oskar Hallatschek Source Type: research
Plant biology: Managing age-related bursts during leaf development
Curr Biol. 2024 Feb 5;34(3):R100-R101. doi: 10.1016/j.cub.2023.12.062.ABSTRACTAge-dependent control of the miR165-regulated SPL transcription factor circuitry is responsible for the variation in leaf morphology over time. A new study reveals the underlying morphogenetic dynamics.PMID:38320472 | DOI:10.1016/j.cub.2023.12.062 (Source: Current Biology)
Source: Current Biology - February 6, 2024 Category: Biology Authors: Yk รค Helariutta Source Type: research
Synaptic promiscuity in brain development
Curr Biol. 2024 Feb 5;34(3):R102-R116. doi: 10.1016/j.cub.2023.12.037.ABSTRACTPrecise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. How does the genome encode brain wiring in light of this apparent contradiction? Synaptic specificity is the outcome of a long series of developmental processes and mechanisms before, during and after synapse formation. How much promiscuity is permissible or necessary at the moment of synaptic partner choice depends on the extent to which prior development restrict...
Source: Current Biology - February 6, 2024 Category: Biology Authors: Neele Wolterhoff P Robin Hiesinger Source Type: research
Monica Gori
Curr Biol. 2024 Feb 5;34(3):R78-R80. doi: 10.1016/j.cub.2023.11.041.ABSTRACTInterview with Monica Gori, who studies visual disability and multisensory skill development in the human brain at the Italian Institute of Technology.PMID:38320474 | DOI:10.1016/j.cub.2023.11.041 (Source: Current Biology)
Source: Current Biology - February 6, 2024 Category: Biology Authors: Monica Gori Source Type: research
