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Current Perspectives on Biological Therapy for COPD
COPD. 2023 Dec;20(1):197-209. doi: 10.1080/15412555.2023.2187210.ABSTRACTChronic obstructive pulmonary disease (COPD) is a chronic, complex, and heterogeneous condition with significant mortality, morbidity, and socioeconomic burden. Given the heterogeneity, the current management of COPD, which mainly relies on bronchodilators and corticosteroids, cannot consider all COPD populations. Moreover, the present treatment modalities are directed at minimizing symptoms and reducing the risk of a future attack, but they exhibit few meaningful anti-inflammatory activities in preventing and reducing disease progression. Therefore, ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 3, 2023 Category: Respiratory Medicine Authors: Ambedkar Kumar Yadav Wenhua Gu Tongyangzi Zhang Xianghuai Xu Li Yu Source Type: research

Reduced Total Airway Count and Airway Wall Tapering after Three-Years in Ex-Smokers
COPD. 2023 Dec;20(1):186-196. doi: 10.1080/15412555.2023.2222831.ABSTRACTComputed tomography (CT) total-airway-count (TAC) and airway wall-thickness differ across chronic obstructive pulmonary disease (COPD) severities, but longitudinal insights are lacking. The aim of this study was to evaluate longitudinal CT airway measurements over three-years in ex-smokers. In this prospective convenience sample study, ex-smokers with (n = 50; 13 female; age = 70 ± 9 years; pack-years = 43 ± 26) and without (n = 40; 17 female; age = 69 ± 10 years; pack-years = 31 ± 17) COPD completed CT, 3He magnetic resonance imaging (MRI), and p...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 3, 2023 Category: Respiratory Medicine Authors: Paulina V Wyszkiewicz Maksym Sharma Vedanth Desaigoudar Ian A Cunningham David G McCormack Mohamed A Abdelrazek Miranda Kirby Grace Parraga Source Type: research

The Relationship between Physical Activity, Depression and Anxiety in People with COPD: A Systematic Review and Meta-analyses
This study systematically synthesized the relationships between physical activity and i) depression and ii) anxiety in people with COPD. Physical activity measurement type (objective, self-report) was examined as a moderator of these relationships. A systematic search of physical activity and COPD was conducted from inception to February 2022 across 8 databases. Studies were included if they provided correlation coefficients for the relationship between measures of physical activity and depression or anxiety in people with COPD and were published in English. Two reviewers independently screened, reviewed and extracted data...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 15, 2023 Category: Respiratory Medicine Authors: Anne-Marie Selzler Cindy Ellerton Lauren Ellerton Razanne Habash Erica Nekolaichuk Roger Goldstein Dina Brooks Source Type: research